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Somatostatin-14 Like Immunoreactive forms in the Rat: Characterization, Distribution and Biosynthesis

  • Yogesh C. Patel
  • Hans H. Zingg
  • C. B. Srikant
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)

Abstract

Tetradecapeptide somatostatin (S-14) was the original form of somatostatin to be isolated (1). The majority of antisera raised against this molecule are directed against the central and C-terminal segments (2) and detect, in addition to S-14, higher mol wt N-terminally extended forms, of which the two principal ones correspond to somatostatin-28 (S-28) and prosomatostatin (pro-S) (Fig. 1). Somatostatin forms detected as S-14 like immunoreactivity (S-14 LI) in mammalian tissues consist of S-14, S-28, pro-S, [des Alal] S-14 (S-13, the principal biologically active circulating metabolite of S-14), and somatostatin-25. The latter species was isolated from ovine hypothalamus along with S-28 but is now generally believed to be a degradation product rather than a naturally occurring somatostatin peptide.

Keywords

High Molecular Weight Form Acetic Acid Extract Culture Islet Cell Hypophyseal Portal Blood Immunoreactive Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Yogesh C. Patel
    • 1
  • Hans H. Zingg
    • 2
  • C. B. Srikant
    • 3
  1. 1.Fraser LaboratoriesMcGill Univ. Depts. of MedicineCanada
  2. 2.Neurology and NeurosurgeryRoyal Victoria HospitalCanada
  3. 3.Montreal Neurological Inst.MontrealCanada

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