Somatostatin-14 Like Immunoreactive forms in the Rat: Characterization, Distribution and Biosynthesis

  • Yogesh C. Patel
  • Hans H. Zingg
  • C. B. Srikant
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


Tetradecapeptide somatostatin (S-14) was the original form of somatostatin to be isolated (1). The majority of antisera raised against this molecule are directed against the central and C-terminal segments (2) and detect, in addition to S-14, higher mol wt N-terminally extended forms, of which the two principal ones correspond to somatostatin-28 (S-28) and prosomatostatin (pro-S) (Fig. 1). Somatostatin forms detected as S-14 like immunoreactivity (S-14 LI) in mammalian tissues consist of S-14, S-28, pro-S, [des Alal] S-14 (S-13, the principal biologically active circulating metabolite of S-14), and somatostatin-25. The latter species was isolated from ovine hypothalamus along with S-28 but is now generally believed to be a degradation product rather than a naturally occurring somatostatin peptide.


High Molecular Weight Form Acetic Acid Extract Culture Islet Cell Hypophyseal Portal Blood Immunoreactive Form 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Yogesh C. Patel
    • 1
  • Hans H. Zingg
    • 2
  • C. B. Srikant
    • 3
  1. 1.Fraser LaboratoriesMcGill Univ. Depts. of MedicineCanada
  2. 2.Neurology and NeurosurgeryRoyal Victoria HospitalCanada
  3. 3.Montreal Neurological Inst.MontrealCanada

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