Somatostatin pp 463-473 | Cite as

Intestinal Somatostatin Function

  • Kiertisin Dharmsathaphorn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


Somatostatin is present throughout the intestine, both in D cells at the luminal surface and in neural elements. It inhibits the release or action of many gut hormones known to regulate gastrointestinal function and undoubtedly has a wide range of actions. In the intestine, available information indicates that somatostatin may have an important regulatory role for water and electrolyte absorption and secretion. The peptide affects both the epithelial transport function and the intestinal motility function. The outcome associated with administration of somatostatin is inhibition of water and electrolyte secretion. Somatostatin has been shown to effectively reduce stool output in diarrheal syndromes associated with endocrine tumor and other conditions. Clinical application of somatostatin in diarrhea still awaits development of an orally active and/or gut-specific analog. Some preliminary results indicate that this may be possible in the future.


Gastric Inhibitory Polypeptide Carcinoid Syndrome Glucagon Release Rabbit Ileum Transport Potency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Kiertisin Dharmsathaphorn
    • 1
  1. 1.Department of MedicineUniversity of California San Diego Medical CenterSan DiegoUSA

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