Somatostatin pp 425-445 | Cite as

Role of Somatostatin in Nutrient Regulation

  • V. Schusdziarra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


Somatostatin-immunoreactive material has been found in D cells of the stomach, small intestine and pancreas (1–6); additionally, it is present in vagal nerve fibres and in neurons of the myenteric and submucosal plexus of the intestinal tract (7–9). Within the gastrointestinal tract and pancreas, an accumulation of D cells has been demonstrated in the fundic and antral area of the stomach and in the islets of Langerhans, whereas a more scattered distribution has been shown in the small and large intestine (10–12). This localization of somatostatin in organs which are exclusively responsible for adequate digestion, absorption and disposal of ingested nutrients raises the possibility that somatostatin might participate in the regulation of nutrient entry from the gastrointestinal tract into the circulation. Thus, somatostatin-containing D cells are in contact with nutrients at all stages of nutrient assimilation.


Harris Versus Opiate Receptor Antagonist Naloxone Maier Versus Schusdziarra Versus 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • V. Schusdziarra
    • 1
  1. 1.Department of Internal Medicine IUniversity of UlmUlm/DonauGermany

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