Somatostatin pp 403-423 | Cite as

Pancreatic Somatostatin

  • Gordon C. Weir
  • Susan Bonner-Weir
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


This is a review of pancreatic somatostatin which is limited in its scope and therefore focuses upon some selected issues. Throughout the entire review the same basic questions recur: Why do islets contain somatostatin? What is the physiological role of somatostatin and what does this peptide have to do with diabetes? Clear answers to these questions do not emerge, but a number of hunches are explored. The review provides a very brief look at somatostatin secretion, a discussion of the potential interactions which islet D cells might have with other islet cell types, consideration of how knowledge of islet anatomy may help us understand the D cell, and finally some comments about what happens to the D cell in diabetes and fasting.


Glucagon Secretion Glucagon Release Intact Islet Perfuse Pancreas Islet Cell Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Gordon C. Weir
    • 1
  • Susan Bonner-Weir
    • 1
  1. 1.Department of Internal MedicineMedical College of VirginiaRichmondUSA

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