Somatostatin pp 383-402 | Cite as

Distribution and Morphology of Somatostatin Cells

  • Lars-Inge Larsson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


After its isolation from the hypothalamus as a neuroendocrine regulator of anterior pituitary growth hormone secretion, somatostatin was rapidly shown to possess many extrapituitary actions and to be widely distributed in the body. Somatostatin was, hence, found to be a potent inhibitor of the secretion of insulin, glucagon, gastrin and several other hormones as well as to inhibit exocrine secretion from the stomach and pancreas (see 1 for review). These actions correlated with the finding of somatostatin immunoreactants in endocrine-like D cells of the entire gastrointestinal tract and the pancreas (2–4). Additionally, somatostatin-like immunoreactivity was detected in a widespread system of central and peripheral nerves (2), in calcitonin-producing C cells of the thyroid (2, 5, 6), in the submandibular gland (7), placenta (8, 9) and urinary tract (l0).


Gastric Inhibitory Polypeptide Gastrin Release Gastrin Secretion Gastrin Cell Paracrine Secretion 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Lars-Inge Larsson
    • 1
  1. 1.Unit of HistochemistryUniversity Institute of PathologyCopenhagen ØDenmark

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