Somatostatin pp 339-353 | Cite as

Clinical Applications of Somatostatin Analogs

  • Peter Marbach
  • Michael Neufeld
  • Janos Pless
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


It has often been shown that tetradecapeptide somatostatin (S-14), discovered in 1973 by Brazeau et al. (1), is effective in the treatment of acromegaly, as adjunct to insulin therapy of type I diabetes, in stopping gastrointestinal bleeding, in treatment of carcinoid syndrome, etc. But S-14 has always had to be given as an iv infusion, which has severely limited its practical application. It was therefore an important exercise of peptide chemists to improve the metabolic stability of the molecule, i.e. to synthesize analogs with a longer duration of action. However, until quite recently, little progress had been made in providing clinically useful compounds.


Acromegalic Patient Carcinoid Syndrome Glucagon Release Increase Infusion Rate Octapeptide Analogue 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Peter Marbach
    • 1
  • Michael Neufeld
    • 1
  • Janos Pless
    • 1
  1. 1.Preclinical and Clinical Research Dept.Sandoz Ltd.BaselSwitzerland

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