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Somatostatin Alterations and Brain Diseases

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Somatostatin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 188))

Abstract

Soon after its discovery as a hypothalamic growth hormone inhibiting factor, somatostatin-14 (S-14, SRIF) was localized by radioimmunoassay (1, 2) and immunocytochemistry (3–5) in extra-hypothalamic structures. Present in neurons, S-14 is synthesized as part of a prohormone and transported to nerve terminals from which it is released in response to depolarizing stimuli. The peptide is then degraded in situ by enzymes after binding to its specific receptors (6, 7). In the pituitary, S-14 seems to act by inhibiting adenylate cyclase (8–10); but in the brain, its mechanism of action is still poorly understood.

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Author information

Authors and Affiliations

  1. Unités 159, Paris, France

    J. Epelbaum, A. Enjalbert, C. Kordon, Y. Lamour & E. Moyse

  2. 114, 161 INSERM, Paris, France

    M. Hamon

  3. Laboratoire de Médecine Expérimentale de la Pitié, Paris, France

    Y. Agid & F. Javoy-Agid

Authors
  1. J. Epelbaum
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  2. Y. Agid
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  3. A. Enjalbert
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  4. M. Hamon
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  6. C. Kordon
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  7. Y. Lamour
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Editor information

Editors and Affiliations

  1. McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada

    Yogesh C. Patel

  2. McGill University and McGill University-Montreal Children’s Hospital Research Institute, Montreal, Quebec, Canada

    Gloria S. Tannenbaum

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© 1985 Springer Science+Business Media New York

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Epelbaum, J. et al. (1985). Somatostatin Alterations and Brain Diseases. In: Patel, Y.C., Tannenbaum, G.S. (eds) Somatostatin. Advances in Experimental Medicine and Biology, vol 188. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7886-4_15

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  • DOI: https://doi.org/10.1007/978-1-4615-7886-4_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7888-8

  • Online ISBN: 978-1-4615-7886-4

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