Somatostatin pp 261-274 | Cite as

Somatostatin Alterations and Brain Diseases

  • J. Epelbaum
  • Y. Agid
  • A. Enjalbert
  • M. Hamon
  • F. Javoy-Agid
  • C. Kordon
  • Y. Lamour
  • E. Moyse
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


Soon after its discovery as a hypothalamic growth hormone inhibiting factor, somatostatin-14 (S-14, SRIF) was localized by radioimmunoassay (1, 2) and immunocytochemistry (3–5) in extra-hypothalamic structures. Present in neurons, S-14 is synthesized as part of a prohormone and transported to nerve terminals from which it is released in response to depolarizing stimuli. The peptide is then degraded in situ by enzymes after binding to its specific receptors (6, 7). In the pituitary, S-14 seems to act by inhibiting adenylate cyclase (8–10); but in the brain, its mechanism of action is still poorly understood.


Laminar Distribution Cholinergic Marker Choline Acetyl Transferase Human Frontal Cortex Parkinsonian Subject 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • J. Epelbaum
    • 1
  • Y. Agid
    • 3
  • A. Enjalbert
    • 1
  • M. Hamon
    • 2
  • F. Javoy-Agid
    • 3
  • C. Kordon
    • 1
  • Y. Lamour
    • 1
  • E. Moyse
    • 1
  1. 1.Unités 159ParisFrance
  2. 2.114, 161 INSERMParisFrance
  3. 3.Laboratoire de Médecine Expérimentale de la PitiéParisFrance

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