Somatostatin pp 229-259 | Cite as

Physiological Role of Somatostatin in Regulation of Pulsatile Growth Hormone Secretion

  • Gloria Shaffer Tannenbaum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


Regulation of the secretion of anterior pituitary hormones, in general, and growth hormone (GH), in particular, is achieved by the remarkably complex interaction of neural and feedback regulatory components. It is now generally recognized that central nervous system (CNS) control of GH secretion occurs by way of the intricate interplay of at least two hypothalamic hypophysiotrophic hormones — one stimulatory, a GH-releasing factor, GRF, and one inhibitory, a GH-release inhibiting factor, somatostatin. The objective of this chapter is to review our current understanding of the regulatory mechanisms for the control of GH secretion, with particular emphasis on the physiological role of somatostatin in GH regulation.


Growth Hormone Growth Hormone Secretion Peak Growth Hormone Growth Hormone Release Factor Ultradian Rhythm 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Gloria Shaffer Tannenbaum
    • 1
  1. 1.Departments of Pediatrics, and Neurology and NeurosurgeryMcGill University and Montreal Children’s HospitalMontrealCanada

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