Somatostatin pp 217-228 | Cite as

Central Nervous System Actions of Somatostatin-Related Peptides

  • Marvin R. Brown
  • Laurel A. Fisher
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


Somatostatin-related peptides act within the central nervous system to influence adrenomedullary epinephrine secretion and thermoregulation. Cysteamine-induced depletion of brain somatostatinrelated peptides or central administration of a somatostatin receptor antagonist alters adrenomedullary epinephrine secretion and thermoregulation in a predictable manner. The actions of cysteamine and the somatostatin receptor antagonist are reversed by administration of somatostatins into the central nervous system, supporting the hypothesis that endogenous brain somatostatin-related peptides are involved in the regulation of adrenomedullary epinephrine secretion and thermoregulation.


Plasma Epinephrine Central Nervous System Action Discrete Brain Region Epinephrine Secretion Central Nervous System Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Marvin R. Brown
    • 1
  • Laurel A. Fisher
    • 1
  1. 1.Peptide Biology LaboratoryThe Salk InstituteLa JollaUSA

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