Somatostatin pp 201-215 | Cite as

Somatostatin and the Cerebral Cortex

  • Richard Robbins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 188)


A unique subset of interneurons which are rich in immunoreactive somatostatin (IRS) exists in the cerebral cortex. The regulation of IRS secretion by these cells is reviewed. Acetylcholine, glutamic acid and several neuropeptides including VIP, CCK, and metenkephalin have been identified as IRS secretagogues. The types of molecules which stimulate IRS release, the electrophysiologic effects of somatostatin, and the recognition of abnormal IRS levels in human CNS diseases were all used to formulate a working model of the role of the somatostatinergic cell in ongoing cerebral cortical function.


Cerebral Cortex Vasoactive Intestinal Peptide Senile Dementia Gastric Inhibitory Polypeptide Cerebral Cortical Neuron 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Richard Robbins
    • 1
  1. 1.Neuroendocrine Section, Endocrinology DivisionUniversity of Colorado Health Sciences CenterDenverUSA

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