Abstract
The red blood cell (RBC) is a free-floating cell whose physiological function is strongly dependent on the permeability properties of its cell membrane (Passow, 1964; Sachs et al., 1975). Although RBCs are relatively simple, they are, like more complicated cells, able to maintain a constant cell volume and a highly asymmetrical transmembrane ion distribution. Furthermore, RBCs can undergo marked membrane permeability changes in response to specific stimuli (Lew and Ferreira, 1978). Such activatable permeabilities are not regenerative but do share similarities with certain membrane ion permeabilities in excitable cells.
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References
Blum, R. M., and Hoffman, J. F., 1971, The membrane locus of Ca-stimulated K transport in energy depleted human red blood cells,J. Membr. Biol. 6:315–328.
Cala, P. M., 1977, Volume regulation by flounder red blood cells in anisotonic media,J. Gen. Physiol. 69:537–552.
Cala, P. M., 1980, Volume regulation by Amphiuma red blood cells. The membrane potential and its implication regarding the nature of the ion-flux pathways,J. Gen. Physiol. 76:683–708.
Cole, K. S., 1972, Membranes, Ions and Impulses, University of California Press, Berkeley.
Dalmark, M., and Wieth, J. O., 1972, Temperature dependence of chloride, bromide, iodide, thiogamate and salicyclate transport in human red cells,J. Physiol. (Lond.) 224:583–610.
Davoren, P. R., and Sutherland, E. W., 1963, The effect of L-epinephrine and other agents in the synthesis and release of adenosine 3’-5’ phosphate by whole pigeon erythrocytes, J. Biol. Chem. 238:3009–3015.
Davson, H., 1937, The loss of potassium from the erythrocyte in hypotonic saline, J. Cell. Comp. Physiol. 10:247.
Fenwick, E., Marty, A., and Neher, E., 1982, A patch clamp study of bovine chromaffin cells and to their sensitivity to acetylcholine, J. Physiol. (Lond.) 331:577–597.
Fricke, H., and Morse, S., 1925, The electric resistance and capacity of blood for frequencies between 800 and 4 1/2 million cycles,J. Gen. Physiol. 9:153–167.
Gardos, G., 1958, The function of calcium in the potassium permeability of human erythrocytes, Biochim. Biophys. Acta 30:653–654.
George, J. N., Weed, R. I., and Reed, C. F., 1977, Adhesion of human erythrocytes to glass. The nature of the interaction and the effect of serum and plasma,J. Cell. Physiol. 77:51–60.
Gingell, D., Todd, I., and Parsegian, V. A., 1977, Long-range attraction between red cells and a hydrocarbon surface, Nature 268:767–769.
Grinnell, F., 1978, Cellular adhesiveness and extracellular substrata, Int. Rev. Cytol. 53:65–144.
Grinstein, S., Dupre, A., and Rothstein, A., 1982, Volume regulation by human lymphocytes. Role of calcium,J. Gen. Physiol. 79:849–869.
Gunn, R. B., Dalmark, M., Tosteson, D. C., and Wieth, J. O., 1973, Characteristics of chloride transport in human red blood cells,J. Gen. Physiol. 61:185–206.
Hamill, O. P., 1981, Potassium channel currents in human red blood cells,J. Physiol. (Lond.) 319:97–98P.
Hamill, O. P., 1982, Ca and volume sensitive K channels in frog red blood cells. Pfluegers Arch. 394:R30.
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F., 1981, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pfluegers Arch. 391:85–100.
Heinz, A., and Passow, H., 1980, The role of external potassium in the calcium-induced potassium efflux from human red blood cell ghosts,J. Membr. Biol. 57:119–131.
Hodgkin, A. L., and Horowicz, P., 1959, The influence of potassium and chloride ions on the membrane potential of single muscle fibres,J. Physiol. (Lond.) 148:127–160.
Hoffman, J. F., and Laris, P. C., 1974, Determination of membrane potentials in human and amphiuma red blood cells by means of a fluorescent probe,J. Physiol. (Lond.) 239:519–552.
Hunter, M. J., 1971, A quantitative estimate of the non-exchange-restricted chloride permeability of the human red cell,J. Physiol. (Lond.) 218:49P.
Johnson, S. L., and Woodbury, J. W., 1964, Membrane resistance of human red cells,J. Gen. Physiol. 47:827–847.
Knauf, P. A., Fuhrmann, G. F., Rothstein, S., and Rothstein, A., 1977, The relationship between anion exchange and net anion flow across the human red blood cell membrane,J. Gen. Physiol. 69:363–386.
Knauf, P. A., Riordan, J. R., Schuhmann, B., Wood-Guth, I., and Passow, H., 1975, Calcium-potassium stimulated net potassium efflux from human erythrocyte ghosts,J. Membr. Biol. 25:1–22.
Kregenow, F. M., 1971, The response of duck erythrocytes to non-hemolytic hypotonic media,J. Gen. Physiol. 58:372–395.
Kregenow, F. M., 1981, Osmoregulatory salt transporting mechanisms: Control of cell volume in anisotonic media, Annu. Rev. Physiol. 43:493–505.
Kregenow, F. M., Robbie, D. E., and Orloff, J., 1976, Effect of norepinephrine and hypertonicity on K influx and cyclic AMP in duck erythrocytes, Am. J. Physiol. 231:306–312.
Lassen, U. V., Pope, L., and Vestergaard-Bogind, B., 1978, Chloride conductance of the Amphiuma red cell membrane,J. Membr. Biol. 39:27–48.
Lew, V. L., 1971, On the ATP dependence of the Ca++-induced increase in K+ permeability observed in human red cells, Biochim. Biophys. Acta 233:827–830.
Lew, V. L., and Ferreira, H. G., 1976, Variable Ca sensitivity of a K selective channel in intact red cell membrane, Nature 263:336–338.
Lew, V. F., and Ferriera, H. G., 1978, Calcium transport and the properties of a calcium-activated potassium channel in red cell membranes, Curr. Top. Membr. Transp. 10:217–271.
Marino, D., Sarkadi, B., Gardos, G., and Bolis, L., 1981, Calcium-induced alkali cation transport in nucleated red cells, Mol. Physiol. 1:295–300.
Neher, E., 1982, Unit conductance studies in biological membrane, in: Techniques in Cellular Physiology, Vol. Pl/II (P. F. Baker, ed.), pp. 1–16, Elsevier/North Holland, County Clare, Ireland.
Neher, E., Sakmann, B., and Steinbach, J. H., 1978, The extracellular patch clamp: A method for resolving current through individual open channels in biological membranes, Pfluegers Arch. 375:219–228.
Orskov, S. L., 1956, Experiments on the influence of adrenaline and noradrenaline on the potassium absorption of RBCs from pigeon and frogs, Acta Physiol. Scand. 37:299.
Parker, J. C., Gitelman, H. J., Glosson, P. S., and Leonard, D. L., 1975, Role of calcium in volume regulation by dog red blood cells,J. Gen. Physiol. 65:84–96.
Passow, H., 1964, Ion and water permeability of the red blood cell, in: The Red Blood Cell (C. Bishop and D. Surgenor, eds.), pp. 71–145, Academic Press, New York.
Post, R. L., and Jolly, P. C., 1957, The linkage of sodium, potassium and ammonium active transport across the human erythrocyte membrane, Biochim. Biophys. Acta 25:118–128.
Poznasky, M., and Solomon, A. K., 1972, Regulation of human red cell volume by linked cation fluxes, J. Membr. Biol. 10:259–266.
Riddick, D. H., Kregenow, F. M., and Orloff, J., 1971, Effect of norepinephrine and dibutyryl cyclic adenosine monophosphate on cation transport in duck erythrocytes, J. Gen. Physiol. 57:752–766.
Rosen, O. M., and Rosen, S. M., 1969, Properties of an adenyl cyclase partially purified from frog erythrocytes, Arch. Biochem. Biophys. 131:449–456.
Rossi, J. P. F. C., and Schatzmann, H. J., 1982, Is the red cell calcium pump electrogenic? J. Physiol. (Lorn.) 327:1–15.
Schatzmann, H. J., 1975, Active calcium transport and Ca++ activated ATPase in human red cell, Curr. Top. Membr. Transp. 6:125–168.
Sachs, J. R., Knauf, P. A., and Dunham, P. B., 1975, Transport through red cell membrane, in: The Red Blood Cell, Vol. II (D. M. Surgenor, ed.), pp. 613–707, Academic Press, New York.
Sen, A. K., and Post, R. L., 1964, Stoichiometry and localization of adenosine triphosphate-dependent sodium and potassium transport in the erythrocyte,J. Biol. Chem. 239:345–352.
Simons, T. J. B., 1976, Calcium dependent potassium exchange in human red cell ghosts,J. Physiol. (Lond.) 256:227–244.
Szasz, I., Sarkadi, B., and Gardos, G., 1977, Mechanism of Ca++-dependent selective rapid K+-transport induced by propranolol in red cells,J. Membr. Biol. 35:75–93.
Szebeni, J., 1981, The Ca2+-sensitive K+ transport in inside-out red cell membrane vesicles, Acta. Biochim. Biophys. Acad. Sci. Hung. 16:77–82.
Tosteson, D. C., and Hoffman, J. F., 1960, Regulation of cell volume by active cation transport in high and low potassium sheep red cells, J. Gen. Physiol. 44:169–194.
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© 1983 Plenum Press, New York
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Hamill, O.P. (1983). Potassium and Chloride Channels in Red Blood Cells. In: Sakmann, B., Neher, E. (eds) Single-Channel Recording. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7858-1_24
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DOI: https://doi.org/10.1007/978-1-4615-7858-1_24
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