Abstract
In view of the wealth of information available on the physiology and pharmacology of cholinergic synapses, particularly those on vertebrate excitable cells, it is not surprising that the cholinergic nicotinic receptor has been greatly influential in shaping current views of receptor pharmacology, receptor-channel kinetics, and synaptic function. But it would be unwise to assume that these views are generally applicable to other receptor systems. For many years, our laboratory has studied the noncholinergic, glutamatergic synapses found on locust leg muscle (Usherwood, 1978) and has recently demonstrated that this system offers considerable advantages for patch clamp analyses of single receptor-channel complexes. Of significance is the discovery that the kinetics of glutamate receptors on locust muscle may differ in some significant respects from their nicotinic acetylcholine receptor counterparts on vertebrate skeletal muscle.
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© 1983 Plenum Press, New York
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Gration, K.A.F., Ramsey, R.L., Usherwood, P.N.R. (1983). Analysis of Single-Channel Data from Glutamate Receptor-Channel Complexes on Locust Muscle. In: Sakmann, B., Neher, E. (eds) Single-Channel Recording. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7858-1_18
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DOI: https://doi.org/10.1007/978-1-4615-7858-1_18
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