Abstract
Short-term genetic bioassays are now widely employed to screen both individual chemicals (e.g., pesticides and toxic substances) and complex mixtures (e.g., industrial effluents and automotive emissions) for mutagenic and potential carcinogenic activity. These bioassays are often employed in a tiered or phased approach to prioritize substances for more expensive chronic animal testing (Bridges, 1973; Waters, 1978). The results of both microbial and mammalian cell genetic bioassays are now considered by governmental regulatory agencies and international organizations to provide important suggestive evidence of a substance’s carcinogenicity in humans (Interagency Regulatory Liason Group, 1979; International Agency for Research on Cancer, 1983).
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Lewtas, J. (1985). Comparative Potency of Complex Mixtures: Use of Short-Term Genetic Bioassays in Cancer Risk Assessment. In: Waters, M.D., Sandhu, S.S., Lewtas, J., Claxton, L., Strauss, G., Nesnow, S. (eds) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV. Environmental Science Research, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7849-9_27
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DOI: https://doi.org/10.1007/978-1-4615-7849-9_27
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