Skip to main content

Correlation Between In Vivo Tumorigenesis and In Vitro Cytotoxicity in Cho and V79 Cells after Exposure to Mineral Fibers

  • Chapter
Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV

Part of the book series: Environmental Science Research ((ESRH,volume 32))

Abstract

It is well known that occupational exposure to asbestos constitutes a major public health hazard. It is also recognized that asbestos already in the environment such as in sprayed accoustical ceilings in schools (Nicholson et al., 1979), emissions from building demolition, and reintrainment of dust from asbestos waste dumps presents a possible threat to the general population (Nicholson and Pundsack, 1973). Furthermore, chronic pleural fibrosis and even tumors of the lungs and pleura are known to be associated with asbestos and asbestos-like minerals in the natural environment (Kiviluoto, 1966; Baris et al., 1978). Substitutes for asbestos are currently being sought, but unfortunately the very properties (durable thin fibers) that provide insulation from high temperature are also likely to enhance the substitute’s tumorigenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Artvenli, M., and Y.I. Baris. 1979. Malignant mesotheliomas in a small village in the Antolian region of Turkey: An epidemiological study. J. Natl. Cancer Inst. 63:17–22.

    Google Scholar 

  • Baris, Y.I., A.A. Sahin, M. Ozesmi, I. Kerse, E. Ozen, B. Kolacan, M. Altinors, and A. Groktepeli. 1978. An outbreak of pleural mesothelioma and chronic fibrosing pleurisy in the village of Karain/Urgup in Anatolia. Thorax 33:181–192.

    Article  Google Scholar 

  • Bridges, B. 1976. Use of a three-tier protocol for evaluation of long-term toxic hazards particularly mutagenicity and carcinogenicity. In: Screening Tests in Chemical Carcinogenesis. IARC Scientific Publication No. 12. International Agency for Research on Cancer: Lyon, France, pp. 549–559.

    Google Scholar 

  • Brown, R.C., and M. Chamberlain. 1980. The activity of two types of asbestos in tissue culture. In: Biological Effects of Mineral Fibers, Volume I. J.C. Wagner, ed. Inserm Symposia Series Volume 92. International Agency for Research on Cancer: Lyon, France, pp. 40–407.

    Google Scholar 

  • Chamberlain, M., R. Davies, R.G. Brown, and D.M. Griffiths. 1982. In vitro tests for the pathogenicity of mineral dusts. In: Inhaled Particles. V. W.H. Walton, ed. Pergamon Press: Oxford, pp. 583–592.

    Google Scholar 

  • Coffin, D.L., L.D. Palekar, and P.M. Cook. 1982. Tumorigenesis by ferroactinolite minerals. Toxicol. Lett. 13:143–150.

    Article  Google Scholar 

  • Cook, P.M., L.D. Palekar, and D.L. Coffin. 1982. Interpretation of the carcinogenicity of amosite asbestos and ferroactinolite on the basis of retained fiber dose and characteristics. Toxicol. Lett. 13:151–158.

    Article  Google Scholar 

  • Cooper, J.A. II, R. Saracci, and P. Cole. 1979. Describing the validity of carcinogen screening tests. Br. J. Cancer 39:87–89.

    Article  Google Scholar 

  • Kiviluoto, R. 1965. Pleural plaque and asbestos: Further observation on endemic and other non-occupational asbestos. Ann. N.Y. Acad. Sci. 132:235–239.

    Article  ADS  Google Scholar 

  • Light, W.G., and E.T. Wei. 1977. Surface charge and hemolytic activity of asbestos. Environ. Res. 13:135–145.

    Article  Google Scholar 

  • MacMahon, B., and T.F. Pugh. 1970. Epidemiology Principles and Methods. Little, Brown and Co.: Boston, p. 261.

    Google Scholar 

  • Nicholson, W.J., and F.L. Pundsack. 1973. Asbestos in the environment. In: Biological Effects of Asbestos. IARC Scientific Publication No. 8. International Agency for Research on Cancer: Lyon, France, pp. 126–130.

    Google Scholar 

  • Nicholson, W.J., E.J. Sevoslowski Jr., A.N. Porohl, J.D. Todaro, and A. Adams. 1979. Asbestos contamination in the U.S. state schools from use of asbestos surfacing material. Ann. N.Y. Acad. Sci. 330:587–596.

    Article  ADS  Google Scholar 

  • Parzen, E. 1964. Probability and theory on the study of mathematical models of random phenomena. In: Modern Probability Theory and Its Application. John Wiley and Sons: New York. pp. 1–31.

    Google Scholar 

  • Stanton, M.F., and C. Wrench. 1972. Mechanisms of mesothelioma induction with asbestos and fibrous glass. J. Natl. Cancer Inst. 48:797–816.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer Science+Business Media New York

About this chapter

Cite this chapter

Palekar, L.D., Brown, B.G., Coffin, D.L. (1985). Correlation Between In Vivo Tumorigenesis and In Vitro Cytotoxicity in Cho and V79 Cells after Exposure to Mineral Fibers. In: Waters, M.D., Sandhu, S.S., Lewtas, J., Claxton, L., Strauss, G., Nesnow, S. (eds) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV. Environmental Science Research, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7849-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7849-9_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7851-2

  • Online ISBN: 978-1-4615-7849-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics