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Immunologic Aspects of Liver Disease of the Alcoholic

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Research Advances in Alcohol and Drug Problems

Abstract

The immune system identifies native, altered, and foreign macromolecules; it attempts to eliminate the latter two groups, which include neoantigens, toxins, and infectious agents. This process is carried out by (1) specific immune reactions such as antibodies produced by bone-marrow-derived B cells, cell-mediated activity resulting from thymus-derived T cells, and macrophages; (2) immune augmenters—nonspecific complement proteins, polymorphonuclear leukocytes, and phagocytic cells. The thymic-dependent arm fosters cells clonally committed to individual antigens; production of cytotoxic, memory, helper, and suppressor lymphocytes subsets; recruitment of mononuclear phagocytes and interaction with surface constituents of other cells to induce inflammation; and promotion of vascular permeability and blood coagulation (Cerottini, 1977).

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Authors and Affiliations

  1. Division of Digestive Diseases—Hepatology, USA

    Carroll M. Leevy, Natarajan Kanagasundaram & Thomas Chen

  2. Department of Medicine, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA

    Carroll M. Leevy, Natarajan Kanagasundaram & Thomas Chen

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  1. Carroll M. Leevy
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  2. Natarajan Kanagasundaram
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  3. Thomas Chen
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Editors and Affiliations

  1. Addiction Research Foundation, Toronto, Ontario, Canada

    Yedy Israel , Frederick B. Glaser , Harold Kalant , Robert E. Popham , Wolfgang Schmidt  & Reginald G. Smart , , , ,  & 

  2. University of Toronto, Toronto, Ontario, Canada

    Yedy Israel , Frederick B. Glaser , Harold Kalant , Robert E. Popham , Wolfgang Schmidt  & Reginald G. Smart , , , ,  & 

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© 1981 Plenum Press, New York

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Leevy, C.M., Kanagasundaram, N., Chen, T. (1981). Immunologic Aspects of Liver Disease of the Alcoholic. In: Israel, Y., Glaser, F.B., Kalant, H., Popham, R.E., Schmidt, W., Smart, R.G. (eds) Research Advances in Alcohol and Drug Problems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7740-9_8

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  • DOI: https://doi.org/10.1007/978-1-4615-7740-9_8

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