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Central Stimulants

Clinical and Experimental Evidence on Tolerance and Sensitization

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Research Advances in Alcohol and Drug Problems

Abstract

Clinical and laboratory evidence are now substantial that both tolerance and sensitization phenomena can be observed following chronic psychomotor stimulant administration. In this chapter I shall review selected studies providing evidence for tolerance and sensitization and discuss factors which may relate to the appearance of these apparently opposite responses. The behavioral phenomenology associated with the development of tolerance and sensitization will be briefly reviewed in the first section. A variety of variables that may affect the manifestation of tolerance or sensitization are discussed. For example, the specifics of the experimental design or clinical drug administration situations appear to play a critical role in determining whether tolerance or sensitization is manifest.

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  1. Section of Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, 20205, USA

    Robert M. Post

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  1. Addiction Research Foundation, Toronto, Ontario, Canada

    Yedy Israel , Frederick B. Glaser , Harold Kalant , Robert E. Popham , Wolfgang Schmidt  & Reginald G. Smart , , , ,  & 

  2. University of Toronto, Toronto, Ontario, Canada

    Yedy Israel , Frederick B. Glaser , Harold Kalant , Robert E. Popham , Wolfgang Schmidt  & Reginald G. Smart , , , ,  & 

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Post, R.M. (1981). Central Stimulants. In: Israel, Y., Glaser, F.B., Kalant, H., Popham, R.E., Schmidt, W., Smart, R.G. (eds) Research Advances in Alcohol and Drug Problems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7740-9_1

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