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Reference Values of Orotic Acid, Uracil and Pseudouridine in Urine

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 309B)

Abstract

Measuring urinary orotic acid and uracil which are intermediates in pyrimidine biosynthesis, is important for screening inborn errors of metabolism, such as urea cycle[1] and pyrimidine metabolism disorders[2,3]. Pseudouridine is a degradation substance from transfer RNA and its measurement might be useful as a marker for cancer and cancer therapy evaluation[4]. Until now, there have been no reports of reference values classified by age. We are presenting the orotic acid, uracil and pseudouridine reference values measured by using high performance liquid chromatography (HPLC) with an automated column switching system[5].

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References

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© 1991 Plenum Press, New York

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Ohba, S., Kidouchi, K., Nakamura, C., Katoh, T., Kobayashi, M., Wada, Y. (1991). Reference Values of Orotic Acid, Uracil and Pseudouridine in Urine. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309B. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7703-4_6

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  • DOI: https://doi.org/10.1007/978-1-4615-7703-4_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-7705-8

  • Online ISBN: 978-1-4615-7703-4

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