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A Single HPLC System for the Evaluation of Purine and Pyrimidine Metabolites in Body Fluids

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 309B)

Abstract

During the last few years several studies1 in the field of inborn errors of metabolism have revealed disorders due to primary deficiency in purine and pyrimidine metabolism. Moreover, abnormal excretory patterns of intermediary metabolites of those compounds have been described in neoplastic and hereditary immunodeficiency diseases as well as in pathophysiological states which lead to primary or secondary hyperammonemia. The determination of pyrimidine metabolites also showed to give clues in the monitoring of the effectiveness of dietary therapy being used to treat patients with hyperammonemia.

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  • DOI: 10.1007/978-1-4615-7703-4_3
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References

  1. H.A. Simmonds, Purine and pyrimidine disorders in “The inherited metabolic diseases”, J.B. Holton, ed., Churchill Livingstone, Inc., New York (1987).

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© 1991 Plenum Press, New York

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Rivera, I.A., de Almeida, I.T., Silveira, C. (1991). A Single HPLC System for the Evaluation of Purine and Pyrimidine Metabolites in Body Fluids. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309B. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7703-4_3

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  • DOI: https://doi.org/10.1007/978-1-4615-7703-4_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-7705-8

  • Online ISBN: 978-1-4615-7703-4

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