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A Single HPLC System for the Evaluation of Purine and Pyrimidine Metabolites in Body Fluids

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Purine and Pyrimidine Metabolism in Man VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 309B))

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Abstract

During the last few years several studies1 in the field of inborn errors of metabolism have revealed disorders due to primary deficiency in purine and pyrimidine metabolism. Moreover, abnormal excretory patterns of intermediary metabolites of those compounds have been described in neoplastic and hereditary immunodeficiency diseases as well as in pathophysiological states which lead to primary or secondary hyperammonemia. The determination of pyrimidine metabolites also showed to give clues in the monitoring of the effectiveness of dietary therapy being used to treat patients with hyperammonemia.

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References

  1. H.A. Simmonds, Purine and pyrimidine disorders in “The inherited metabolic diseases”, J.B. Holton, ed., Churchill Livingstone, Inc., New York (1987).

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  2. A.H. van Gennip, D.Y. van Nordenbung-Huistra, P.K. de Bree and S.K. Wadman, Clin. Chim. Acta 86: 7 (1978)

    Article  PubMed  Google Scholar 

  3. G.S. Morris and H.A. Simmonds, J. Chromatoqr. 344: 101 (1985).

    Article  CAS  Google Scholar 

  4. R.A. de Abreu, J.M. van Baal, C.H.M.M. de Bruyn, J.A.J.M. Bakkeren and E. D. A. M. Schretlen, J. Chromatoqr. 229: 67 (1982).

    Article  Google Scholar 

  5. R.J. Simmonds and R.A. Harkness, J. Chromatoqr. 226: 369 (1981).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Centro de Metabolismos e Genética (I. N. I.C.), Faculdade de Farmácia, 1600, Lisboa, Portugal

    I. A. Rivera, I. Tavares de Almeida & C. Silveira

Authors
  1. I. A. Rivera
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  2. I. Tavares de Almeida
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  3. C. Silveira
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Editor information

Editors and Affiliations

  1. Institute of Child Health, London, UK

    R. Angus Harkness

  2. Burroughs Wellcome Co., Research Triangle Park, North Carolina, USA

    Gertrude B. Elion

  3. Universität München, München, Germany

    Nepomuk Zöllner

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© 1991 Plenum Press, New York

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Rivera, I.A., de Almeida, I.T., Silveira, C. (1991). A Single HPLC System for the Evaluation of Purine and Pyrimidine Metabolites in Body Fluids. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309B. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7703-4_3

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  • DOI: https://doi.org/10.1007/978-1-4615-7703-4_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-7705-8

  • Online ISBN: 978-1-4615-7703-4

  • eBook Packages: Springer Book Archive

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