Skip to main content
SpringerLink
Log in

Cytosolic Purine 5′-Nucleotidase from Chicken Heart : An Isozyme of the Liver Enzyme as Evidenced by Antibodies

  • Chapter
Purine and Pyrimidine Metabolism in Man VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 309B))

Abstract

Purine 5′-nucleotidase (1) is one of soluble nucleotidases which include pyrimidine 5′-nucleotidase (2), deoxyribonucleotidase (3), and AMP-specific 5′-nucleotidase (4). Purine 5′-nucleotidase preferentially hydrolyzes IMP, GMP, and, to a lesser extent, AMP in the presence of magnesium ions. The enzyme is allosterically activated by ATP (5), diadenosine tetraphosphate (6), 2,3-diphosphoglycerate (7) and decavanadate (8), and inhibited by Pi. Purine 5′-nucleotidase is located in the cytoplasmic matrix of the cell (9, 10).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tsushima, K. (1986) Adv. Enzyme Regul. 25, 181–200

    Article  CAS  PubMed  Google Scholar 

  2. Paglia, D. E., and Valentine, W. N. (1975) J. Biol. Chem. 250, 7973–7979

    CAS  PubMed  Google Scholar 

  3. Höglund, L., and Reichard, P. (1990) J. Biol. Chem. 265, 6589–6595

    PubMed  Google Scholar 

  4. Yamazaki, Y., Truong, V. L., and Lowenstein, J. M. (1991) Biochemistry 30, 1503–1509

    Article  CAS  PubMed  Google Scholar 

  5. Van den Berghe, G., Van Pottelsberghe, C., and Hers, H. -G. (1977) Biochem. J. 162, 611–616

    Article  PubMed  PubMed Central  Google Scholar 

  6. Pinto, R. M., Canales, J., Sillero, M. A. G., and Sillero, A. (1986) Biochem. Biophys. Res. Commun. 138, 261–267

    Article  CAS  PubMed  Google Scholar 

  7. Bontemps, F., Vincent, M. F., Van den Bergh, F., van Waeg, G., and Van den Berghe, G. (1989) Biochim. Biophys. Acta 997, 131–134

    Article  CAS  PubMed  Google Scholar 

  8. Le Hir, M. (1991) Biochem. J. 273, 795–798

    Article  PubMed  PubMed Central  Google Scholar 

  9. Yokota, S., Oka, J., Ozasa, H., and Itoh, R. (1988) J. Histochem. Cytochem. 36, 983–989

    Article  CAS  PubMed  Google Scholar 

  10. Oka, J., Ozasa, H., Itoh, R., and Yokota, S. (1989) Adv. Exp. Med. Biol. 253B, 113–118

    Article  CAS  PubMed  Google Scholar 

  11. Naito, Y., and Tsushima, K. (1976) Biochim. Biophys. Acta 438, 159–168

    Article  CAS  PubMed  Google Scholar 

  12. Itoh, R., and Oka, J. (1985) Comp. Biochem. Physiol. 81B, 159–163

    CAS  Google Scholar 

  13. Oka, J., Ozasa, H., Itoh, R., and Yokota, S. (1987) Uric Acid Res. (Tokyo) 11, 13–19 (in Japanese)

    Google Scholar 

  14. Oka, J., Ozasa, H., and Itoh, R. (1988) Biochim. Biophys. Acta 953, 114–118

    Article  CAS  PubMed  Google Scholar 

  15. Itoh, R., and Yamada, K. (1991) Int. J. Biochem. 23, 461–46 5

    Google Scholar 

  16. Berne, R. M. (1980) Circ. Res. 47, 807–813

    Article  CAS  PubMed  Google Scholar 

  17. Itoh, R., Oka, J., and Ozasa, H. (1986) Adv. Exp. Med. Biol. 195B, 299–303

    Google Scholar 

  18. Itoh, R., Oka, J., and Ozasa, H. (1986) Biochem. J. 235, 847–851

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Bardenheuer, H., Whelton, B., and Sparks, H. V. (1987) Circ. Res. 61, 594–600

    Article  CAS  PubMed  Google Scholar 

  20. Shryock, J. C., Rubio, R., and Berne, R. M. (1988) Am. J. Physiol. 254, H223 - H229

    PubMed  CAS  Google Scholar 

  21. Yamada, K., and Itoh, R. (1990) Jpn. J. Pharmacol. 52, Suppl. II, 89P (Abstract)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The National Institute of Health and Nutrition (JO, RI) and Kidney Center, Tokyo Women’s Medical College (HO), Shinjuku-ku, Tokyo 162, Japan

    Jun Oka, Roichi Itoh & Hisashi Ozasa

Authors
  1. Jun Oka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roichi Itoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hisashi Ozasa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Child Health, London, UK

    R. Angus Harkness

  2. Burroughs Wellcome Co., Research Triangle Park, North Carolina, USA

    Gertrude B. Elion

  3. Universität München, München, Germany

    Nepomuk Zöllner

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Oka, J., Itoh, R., Ozasa, H. (1991). Cytosolic Purine 5′-Nucleotidase from Chicken Heart : An Isozyme of the Liver Enzyme as Evidenced by Antibodies. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309B. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7703-4_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7703-4_34

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-7705-8

  • Online ISBN: 978-1-4615-7703-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation