Abstract
A receptor-based biosensor uses biomolecules with specific molecule- recognition capability to detect chemicals. For this proposed receptor-based biosensor, proteins composed of binding sites and ion channels are embedded in a lipid bilayer. The protein-lipid membrane is deposited onto a transducing electrode.1,2 When a chemical of interest binds to the receptor site, the ion channel opens to permit an ionic current to flow through the membrane. The lipid bilayer has two purposes: first, it serves as the medium to support the proteins, and, second, it acts as an insulating membrane on the transducing electrode. The presence of the chemical of interest may thus be detected by the ion current.
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© 1989 Plenum Press, New York
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Fare, T.L. et al. (1989). Incorporation of Ion Channels in Polymerized Membranes and Fabrication of a Biosensor. In: Hong, F.T. (eds) Molecular Electronics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7482-8_32
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DOI: https://doi.org/10.1007/978-1-4615-7482-8_32
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