Abstract
Disturbances in iron metabolism occur in the hemolytic anemias, both congenital and acquired. There is usually an elevated plasma iron level, and a normal or low plasma iron concentration is rare (Heilmeyer, 1964) (see Fig. 7/5). A rise in plasma iron concentration in a given phase of the disease indicates predominance of hemolysis over red cell production. Excessive erythropoiesis results in a change of plasma iron level in the opposite direction (Bothwell and Finch, 1962). The rise in temperature that is frequently associated with hemolytic crises does not influence the iron concentration of the plasma.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsBibliography
Bothwell, T. H., Finch, C. A.: Iron Metabolism. Little, Brown and Co., Boston 1962.
Bothwell, T. H., Callender, S. T., Mallett, B., Witts, L. J.: The study of erythropoiesis using tracer quantities of radioactive iron. Brit. J. Haemat. 2, 1 (1956).
Büchmann, P.: Eisenstoffwechsel bei haemolytischer Anämie. In: Keiderling, W. (ed.): Eisenstoffwechsel, pp. 204–218. Thieme, Stuttgart 1959.
Finch, C. A., Gibson, J. G., Peacock, W. C., Fluharty, R. G.: Iron metabolism. Utilization of intravenous radioactive iron. Blood 4, 905 (1949).
Finch, C. A. et al.: Ferrokinetics in man. Medicine 49, 17 (1970).
Fuhrmann, G., Knüttgen, H.: Serumeisenbefunde bei Malaria tertiana. Z. Tropenmed. Parasit. 1, 515 (1950).
Heilmeyer, L.: Die Störungen der Bluthämsynthese. Thieme, Stuttgart 1964.
Huff, R. L., Hennessy, T. G., Austin, R. E., Garcia, J. F., Roberts, B. M., Lawrence, J. H.: Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J. clin. Invest. 29, 1041 (1950).
Laurell, C.B.: Studies on the transportation and metabolism of iron in the body with special reference to the iron-binding component in human plasma. Acta physiol. scand. 14 (Suppl. 46) (1947).
Moore, C. V., Arrowsmith W. R., Quilligan, J. J., Read, J. T.: Studies in iron transportation and metabolism. J. clin. Invest. 16, 613 (1937).
Morczek, A.: Untersuchungen über den Eisenstoffwechsel. II. Die Eisenausscheidung bei verschiedenen Krankheiten. Dtsch. Z. Verdau.- u. Stoffwechselkr. 12, 14 (1952).
Vahlquist, B.: Das Serumeisen. Acta paediat. Uppsala 28, Suppl. 5 (1941).
Vannotti, A., Delachaux, A.: Der Eisenstoffwechsel und seine klinische Bedeutung. Basel 1942.
Wazewska-Czyzewska, M., Guminska, S.: Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. Brit. J. Haemat. 41, 115 (1979).
Wöhler, F.: The treatment of haemochromatosis with desferrioxamine. In: Gross, F. (ed.): Iron Metabolism. Springer, Berlin-Göttingen-Heidelberg 1964.
Rights and permissions
Copyright information
© 1983 Akadémiai Kiadó, Budapest
About this chapter
Cite this chapter
Bernát, I. (1983). Hemolytic Anemias. In: Iron Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7308-1_23
Download citation
DOI: https://doi.org/10.1007/978-1-4615-7308-1_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-7310-4
Online ISBN: 978-1-4615-7308-1
eBook Packages: Springer Book Archive