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Iron Metabolism pp 301–304Cite as

Pernicious Anemia

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Abstract

Iron metabolism is disturbed in the presence of megaloblastic marrow associated with untreated pernicious anemia. Red cell maturation and differentiation is reduced (Nathan and Gardner, 1962), the absolute and percentage reticulocyte count is lower than normal (Murphy and Howard, 1957; Heilmeyer, 1964), and many of the reticulocytes are immature (Heilmeyer, 1970).

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Reference

  • Bang, O., Orskov, S. L: Variations in the permeability of the red cells in man, with particular reference to the conditions obtained in pernicious anemia. J. clin. Invest. 16, 279 (1937).

    Article  PubMed  CAS  Google Scholar 

  • Beaven, G. H., Ellis, M. J., White, J. C.: Studies on human foetal haemoglobin. II. Foetal haemoglobin levels in healthy children and adults and in certain haematological disorders. Brit. J. Haemat. 6, 201 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Büchmann, P.: Eisenstoffwechsel bei haemolytischer Anämie. In: Keiderling, W.: Eisenstoffwechsel, pp. 204–218. Thieme, Stuttgart 1959.

    Google Scholar 

  • Chanarin, I.: The Megaloblastic Anemias. Davis, Philadelphia 1969.

    Google Scholar 

  • Finch, C. A., Coleman, D. H., Motulsky, A. G., Donohue, D. M., Reiff, R. H.: Erythrokinetics in pernicious anemia. Blood 11, 807 (1956).

    PubMed  Google Scholar 

  • Finch, C. A. et al.: Ferrokinetics in man. Medicine 49, 17 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Fischer, H., Helbig, W.: Diagnostik und Therapie megaloblastischer Anämien. Z. Ges. inn. Med. 32, 425 (1977).

    PubMed  CAS  Google Scholar 

  • Gewitz, R., Collica, C., Miescher, P. A.: Erythrokinetische Studien in der Diagnostik anämischer Zustände. Med. Klin. 57, 1515 (1962).

    Google Scholar 

  • Goldeck, H., Remy, D.: Eisenstoffwechsel und Eisenmangel bei der regenerierenden Perniciosa. Dtsch. Arch. klin. Med. 198, 422 (1951).

    PubMed  CAS  Google Scholar 

  • Hamilton, H. E., de Gowin, E. L., Shetts, R. F., Janney, C. D., Ellis, J. A.: Studies with inagglutinable erythrocyte counts. VI. Accelerated destruction of normal adult erythrocytes in pernicious anemia, contribution of hemolysis to the oligocythemia. J. clin. Invest. 33, 191 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Hawkins, C. F.: Value of serum iron levels in assessing effect of haematinics in the macrocytic anemias. Brit. med. J. 1, 383 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Heilmeyer, L.: Die Störungen der Bluthämsynthese. Thieme, Stuttgart 1964.

    Google Scholar 

  • Heilmeyer, L.: Klinik des erythrocytären Systems. In: Heilmeyer, L., Begemann, H. (eds.): Blut und Blutkrankheiten, Vol. 2/2. Springer, Berlin-Heidelberg-New York 1970.

    Chapter  Google Scholar 

  • Heilmeyer, L., Plötner, K.: Das Serumeisen und die Eisenmangelkrankheit. Fischer, Jena 1937.

    Google Scholar 

  • Huff, R. L., Hennessy, T. G., Austin, R. E., Garcia, J. F., Roberts, B. M., Lawrence, J. H.: Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J. clin. Invest. 29, 1041 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Josephson, A. M., Masri, M. S., Singer, L., Dworkin, D., K.: Starch block electrophoretic studies of human hemoglobin solutions. II. Results in cord blood, thalassemia and other hematologic disorders: Comparison with Tiselius electrophoresis. Blood 13, 543 (1958).

    PubMed  CAS  Google Scholar 

  • Kehl, R., Günther, B.: Zur papierchromatografischen Isomeren-Analyse der Porphyrine. Hoppe-Seylers Z. physiol. Chem. 297, 254 (1954).

    Article  PubMed  CAS  Google Scholar 

  • London, I. M., Shemin D., West, R., Rittenberg, D.: Heme synthesis and red blood cell dynamics in normal humans and in subjects with polycythemia vera, sickle-cell anemia and pernicious anemia. J. biol. Chem. 179, 463 (1949).

    PubMed  CAS  Google Scholar 

  • Moore, C. V., Arrowsmith, W. R., Quilligan, J. J., Read, J. T.: Studies in iron transportation and metabolism. I. J. clin. Invest. 16, 613 (1937).

    Article  CAS  Google Scholar 

  • Moore, C. V., Doan, C. A., Arrowsmith, W. R.: Studies in iron transportation and metabolism. II. The mechanism of iron transportation. Its significance in iron utilization in anemic states of varied etiology. J. clin. Invest. 16, 627 (1937).

    Article  PubMed  CAS  Google Scholar 

  • Murphy, W. P., Howard, J.: A comparison of the effect of the vitamin B12 with that of liver extracts in the treatment of pernicious anemia during relapse and for maintenance. New Engl. J. Med. 247, 838 (1957).

    Article  Google Scholar 

  • Myhre, E.: Studies on the erythrokinetics in pernicious anemia. Scand. J. clin. Lab. Invest. 16, 391 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Nathan, D. G., Gardner, F. H.: Erythroid cell maturation and hemoglobin synthesis in megaloblastic anemia. J. clin. Invest. 41, 1086 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Ponder, E., Rhoads, C. P.: Red cell resistance to lysins in pernicious anemia. Proc. Soc. exp. Biol. Med. 38, 540 (1938).

    Google Scholar 

  • Rechenberger, J.: Über die Eisenbindungskapazität des Blutserums. IV. Das Verhalten der Eisenbindungskapazität und des Serumeisens bei der unbehandelten und regenerierenden perniciösen Anämie. Dtsch. Z. Verdau.- u. Stoffwechselkr. 16, 223 (1956).

    CAS  Google Scholar 

  • Richter, K.: Der Hämoglobingehalt des Blutes bei Anämien, Polycythaemia vera und Polyglobulien. Klin.Wschr. 36, 911 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Saito, G., Moreo, L., Perini, A.: Contributo alla studio délie porfirine libère eritrocitarie nell’anemia de Biermer. Haematologica 43, 51 (1958).

    Google Scholar 

  • Schlegel, B., Böttner, H.: Zur Dynamik der intravitalen Erythrocytolyse. Med. Klin. 36, 1518 (1955).

    Google Scholar 

  • Schlegel, B., Kappest, P.: Untersuchungen zur intravitalen Erythrolyse. Klin. Wschr. 34, 805 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Schmid, J. R., Moeschlin, S., Haegi, V.: Pernicious anemia: an erythrokinetic and autoradiographic study, using H3-thymidine, H3-uridine and H3-cytidine. Acta haemat. (Basel) 32, 65 (1964).

    Article  CAS  Google Scholar 

  • Schmid, R., Schwartz, S., Watson, C. J.: Porphyrins in the bone marrow and circulating erythrocytes in experimental anemias. Proc. Soc. exp. Biol. Med. 75, 705 (1950).

    PubMed  CAS  Google Scholar 

  • Vahlquist, B.: Das Serumeisen. Acta paediat. Uppsala 28, Suppl. 5 (1941).

    Article  Google Scholar 

  • Vannotti, A., Delachaux, A.: Der Eisenstoffwechsel und seine klinische Bedeutung. Basel 1942.

    Google Scholar 

  • Waldenstrom, J.: Perniciös anämi och cancer ventriculi. Nordisk Medicine 25, 1 (1945).

    Google Scholar 

  • Wasserman, L. R., Rashkoff, I. A., Leavitt, D., Mayer, J., Port, S.: The rate of removal of radioactive iron from the plasma—an index of erythropoiesis. J. clin. Invest. 31, 32 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Watson, C. J.: The erythrocyte coproporphyria Variation in respect to erythrocyte protoporphyrin and reticulocytes in certain types of the anemias. Arch, intern. Med. 86, 797 (1950).

    Article  CAS  Google Scholar 

  • Wilms, K.: Die megaloblastären Anämien. In: Queisser, W. (ed.): Das Knochenmark, pp. 414–428. Thieme, Stuttgart 1978.

    Google Scholar 

  • Wintrobe, M. M.: Clinical Hematology. Lea and Febiger, Philadelphia 1967, 1975.

    Google Scholar 

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Authors
  1. Iván Bernát M.D., D.Sc.
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© 1983 Akadémiai Kiadó, Budapest

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Bernát, I. (1983). Pernicious Anemia. In: Iron Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7308-1_22

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  • DOI: https://doi.org/10.1007/978-1-4615-7308-1_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7310-4

  • Online ISBN: 978-1-4615-7308-1

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