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Ion Channels pp 251–282Cite as

The Amiloride-Blockable Sodium Channel of Epithelial Tissue

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Abstract

In many epithelial tissues which are characterized by very high trans-epithelial resistance, a major component of the permeability of the lumen-facing or apical membrane is a conductance which is selective for Na+over other cations and can be specifically blocked by low concentrations of the potassium-sparing diuretic amiloride (see Fig. 1).

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Author notes

  1. Kirk L. Hamilton

    Present address: Department of Physiology and Biophysics, University of Alabama, Birmingham, Alabama, 35294, USA

Authors and Affiliations

  1. Department of Physiology, Emory University Medical School, Atlanta, Georgia, 30322, USA

    Douglas C. Eaton & Kirk L. Hamilton

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  1. Douglas C. Eaton
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Editors and Affiliations

  1. Northwestern University Medical School, Chicago, Illinois, USA

    Toshio Narahashi

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© 1988 Plenum Press, New York

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Eaton, D.C., Hamilton, K.L. (1988). The Amiloride-Blockable Sodium Channel of Epithelial Tissue. In: Narahashi, T. (eds) Ion Channels. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7302-9_7

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  • DOI: https://doi.org/10.1007/978-1-4615-7302-9_7

  • Publisher Name: Springer, Boston, MA

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