Cytogenesis and Developmental Anatomy of the Pia-Arachnoid and Pacchionian Granules

  • Luca Rigobello
Part of the Principles of Pediatric Neurosurgery book series (PRINCPEDIATR)


The membranous coverings, essentially composed of connective tissue, that surround the whole neuraxis are called meninges. The word dates back to Erasistratus,1 whereas Galen distinguished “the pacheia and the lepte,” and after translation into Arabic and at last Latin, the terms dura mater and pia mater came to the modern era.2


Neural Crest Superior Sagittal Sinus Subendothelial Space Arachnoid Granulation Arachnoid Villus 
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  1. 1.
    Skinner HA: The Origin of Medical Terms. Hafner, New York: 1970.Google Scholar
  2. 2.
    O’Rahilly R, Muller F: The meninges in human development. J Neuropathol Exp Neurol 45:588–608, 1986.PubMedCrossRefGoogle Scholar
  3. 3.
    Sterzi G: Ricerche intorno all’anatomia comparata ed all’ontogenesi delle meningi e considerazioni sulla filogenesi. Atti R Ist Veneto di Sci., Lett. ed Arti 60:1101–1372, 1901.Google Scholar
  4. 4.
    Weed LH: The meninges, with special reference to the cell coverings of the leptomeninges. In Penfield W (ed): Cytology and Cellular Pathology of the Nervous System, Vol. 20. Hoeber, New York, 1932, pp. 661–634.Google Scholar
  5. 5.
    Chiarugi F, Bucciante L: Istituzioni di Anatomia dell’Uomo, Vol. 4. Vallardi, Milano, 1968, pp. 663–735.Google Scholar
  6. 6.
    Bargmann W, Oksche A, Fix JD, et al.: Mengines, choroid plexuses, ependyma, and their reactions. Part I: Histology and functional considerations. In Haymaker W, Adams RD (eds): Histology and Histopathology of the Nervous System, Vol. 1. Charles Thomas, Springfield, Ill., 1982, pp. 560–641.Google Scholar
  7. 7.
    Gray M: Gray’s Anatomy. Saunders, Philadelphia, 1972.Google Scholar
  8. 8.
    Taveras JM, Wood EH: Diagnostic Neuro-radiology. Williams & Wilkins, Baltimore, 1964.Google Scholar
  9. 9.
    Tascol M, Izard J: The subdural neurothelium of the cranial meninges in man. Anat Rec 186:429–436, 1976.CrossRefGoogle Scholar
  10. 10.
    Nabeshima S, Reese TS, Landis DMD, et al.: Junctions in the meninges and marginal glia. J Comp Neurol 164:127–169, 1975.PubMedCrossRefGoogle Scholar
  11. 11.
    Schachenmayer W, Friede RL: The origin of subdural neomembranes. I. Fine structure of the dura-arachnoid interface in man. Am J Pathol 92:53–68, 1978.Google Scholar
  12. 12.
    Tuchmann-Duplessis H, Auroux M, Haegel P: Illustrated human embryology, Vol. 3: Nervous System and Endorine Glands.Google Scholar
  13. 13.
    Sidman RL, Rakic P: Development of the human central nervous system. In Haymaker W, Adams RD, eds: Histology and Histopathology of the Nervous System, Vol. 1. Charles C Thomas, Springfield, Ill., 1982 pp. 3–45.Google Scholar
  14. 14.
    Bagnara JT, Matsumoto J, Ferris W, et al.: Common origin of pigment cells. Science 203:410, 1979.PubMedCrossRefGoogle Scholar
  15. 15.
    Salvi G: L’istogenesi e la struttura delle meningi. Men. Soc. Toscana Sci. Nat. Pisa (These de Paris, 1989). 16:187, 1898.Google Scholar
  16. 16.
    Hochstetter F: Uber die Entwicklung und Differenzierung der Hullen der Ruckenmarkes beim Menschen. Morphol Jahrb 74:1–104, 1934.Google Scholar
  17. 17.
    Sensenig EC: The early development of the meninges of the spinal cord in human embryos. In: Contributions to Embriology No. 228. Washington, Carnegie Inst. Publ. 592, 34:145–157, 19Google Scholar
  18. 18.
    Bischoff TLW: Entwicklungsgeschichte der Saugethiere und des Menschen. Vorweg, Leipzig, 1842.Google Scholar
  19. 19.
    Kolliker A von: Grundriss der Entwicklungsgeschichte des Menschen und des hoheren Thiere. Engelmann, Leipzig, 1861.Google Scholar
  20. 20.
    His W: Die Haute und Hohlen des Korpers. Arch Anat Physiol Anat Abt 1903, pp. 368-404.Google Scholar
  21. 21.
    Oberling C: Les tumeurs des meninges. Bull Assoc Franc Etude Cancer 11:365–394, 1922.Google Scholar
  22. 22.
    Harvey SC, Burr HS: An experimental study of the origin of meninges. Proc Soc Exp Med 22:52–53, 1924.CrossRefGoogle Scholar
  23. 23.
    Harvey SC, Burr HS: The development of the meninges. Arch Neurol Psychiat 15:545–567, 1926.CrossRefGoogle Scholar
  24. 24.
    Harvey SC, Burr HS, Van Campenhout E: Development of the meninges. Further experiments. Arch Neurol Psychiat 29:683–690, 1933.CrossRefGoogle Scholar
  25. 25.
    Klika E: L’ultrastructure des meninges en ontogenese de l’homme Z Mikrosk Anat Forsch 79:209–222, 1968.PubMedGoogle Scholar
  26. 26.
    Weed LH: Studies on cerebrospinal fluid. II. The theories of drainage of cerebrospinal fluid with an analysis of the methods of investigation. J Med Res 31:29–50, 1914.Google Scholar
  27. 27.
    Weed LH: Studies on cerebrospinal fluid. III. The pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi. J Med Res 31:51–93, 1914.PubMedGoogle Scholar
  28. 28.
    Braaker P: Gestalt und Entwicklung der sub-arachnoidealen Zisternen beim menschlichen Feten. Acta Anat 91:130–153, 1975.PubMedCrossRefGoogle Scholar
  29. 29.
    Weed LH: The development of the cerebrospinal spaces in pig and in man. In: Contributions to Embryology, Vol. 5, No. 14, Washington, Carnegie Inst. 1917, pp. 5–110.Google Scholar
  30. 30.
    McLone DG: The subarachnoid space: A Review. Child’s Brain, 1980, 6:113–130.PubMedGoogle Scholar
  31. 31.
    Hochstetter F: Beitrage zur Entwicklungsgeschichte des menschlichen Geihirns. Vienna, Deuticke, 1929.Google Scholar
  32. 32.
    Wilson JT: On the nature and mode of origin of the foramen of Magendie. J Anat 71:423–426, 1936.Google Scholar
  33. 33.
    Gardner E, O’Rahilly R, Prolo D: The Dandy-Walker and Arnold-Chiari malformations. Arch Neurol 32:393–407, 1975.PubMedCrossRefGoogle Scholar
  34. 34.
    Jones HC, Dolman GS: The structure of the roof of the fourth ventricle in pigeon and chick brains by light and electron microscopy. J Anat 128:13–29, 1979.PubMedGoogle Scholar
  35. 35.
    Sarnat HB, Netsky MG: Hypothesis: Phylogenetic diseases of the Nervous System. Can J Neurol Sci 11:29–33, 1984.PubMedGoogle Scholar
  36. 36.
    Clark WEL: On the Pacchionian bodies. J Anat 55:40–48, 1920.Google Scholar
  37. 37.
    Andres KH: Zur Feinstruktur der Arachnoidalzotten bei Mammalia. Z Zellforsch 82:92–109, 1967.PubMedCrossRefGoogle Scholar
  38. 38.
    Welch K, Friedman V: The cerebrospinal fluid valves. Brain 83:456–469, 1960.CrossRefGoogle Scholar
  39. 39.
    Cutler RWP, Page L, Galicich J, et al.: Formation and absorption of cerebrospinal fluid in man. Brain 91:707–720, 1968.PubMedCrossRefGoogle Scholar
  40. 40.
    Shabo AL, Maxwell DS: The subarachnoid space following the introduction of a foreign protein: an electron microscopy study with peroxidase. J Neuropathol. Exp Neurol 30:506–524, 1971.Google Scholar
  41. 41.
    Davson H, Hollingsworth G, Segal MB: The mechanism of drainage of the cerebrospinal fluid. Brain 93:665–678, 1970.PubMedCrossRefGoogle Scholar
  42. 42.
    Alksne JF, Lovings ET: Functional ultrastructure of the arachnoid villus. Arch Neurol 27:371–377, 1972.PubMedCrossRefGoogle Scholar
  43. 43.
    D’Avella D, Baroni A, Mingrino S, et al.: An electron microscope study of human arachnoid villi. Surg Neurol 14:41–47, 1980.PubMedGoogle Scholar
  44. 44.
    McComb JG: Recent research into the nature of cerebrospinal fluid formation and absorption. J Neurosurg 59:369–383, 1983.PubMedCrossRefGoogle Scholar
  45. 45.
    Jayatilaka ADP: Arachnoid granulations in sheep. J Anat 99:315–327, 1965.PubMedGoogle Scholar
  46. 46.
    Potts DG, Reilly KF, Deonarine V: Morphology of the arachnoid villi and granulations. Radiology 105:333–341, 1972.PubMedGoogle Scholar
  47. 47.
    Pacchioni A: Opera. Romae, apud Thomam et Nicolaum Pagliarinos, 1741.Google Scholar
  48. 48.
    Millen JW, Woollam DHM: The Anatomy of the Cerebrospinal Fluid. Oxford University Press, London, 1962.Google Scholar
  49. 49.
    Turner L: The structure of arachnoid granulations with observations on their physiological and pathological significance. Ann Roy Coll Surg Eng 29:237–264, 1961.PubMedGoogle Scholar
  50. 50.
    Key EAH, Retzius GM: Studien in der Anatomie des Nervensystems und des Bindegewebes, Vol. I. Norstedt. Stockolm. 1875.Google Scholar
  51. 51.
    Upton ML, Weller RO: The morphology of cerebrospinal fluid drainage pathways in human arachnoid granulations. J Neurosurg 63:867–875, 1985.PubMedCrossRefGoogle Scholar
  52. 52.
    Yamashima T: Functional ultrastructure of cerebrospinal fluid drainage channels in human arachnoid villi. Neurosurgery 22:633–641, 1988.PubMedCrossRefGoogle Scholar
  53. 53.
    Wolpow ER, Schaumburg HH: Structure of the human arachnoid granulation. J Neurosurg 37:724–727, 1972.PubMedCrossRefGoogle Scholar
  54. 54.
    Andrioli GC, Dollo C, Rigobello L, et al.: Structure of the arachnoid villi in the superior sagittal sinus in man. Presented at the IXth International Congress of Neuropathology, 1982, Sept. 5–10, Wien. Abstracts book, p. 217.Google Scholar
  55. 55.
    Cooper ER: Arachnoid granulations in man. Acta Anat 34:187–200, 1958.PubMedCrossRefGoogle Scholar
  56. 56.
    Elmann R: Spinal arachnoid granulations with expecial reference to the cerebrospinal fluid. John Hopkins Hosp Bull, 34:99, 1923.Google Scholar
  57. 57.
    Welch K, Pollay M: The spinal arachnoid villi of the monkeys cercopithecus aethiops sabaeus and macaca irus. Anat Rec 145:45–48, 1963.CrossRefGoogle Scholar
  58. 58.
    Woollam DH, Millen JW: Observations on the production and circulation of the cerebrospinal fluid. In Wolstenholme GEW, O’Connor EM, eds.: Ciba Foundation Symposium on the Cerebrospinal Fluid: Production, Circulation and Absorption. Boston, Little, 1958, p. 124.Google Scholar
  59. 59.
    Shanthaveerappa TR, Bourne GH: Arachnoid villi in the optic nerve of man and monkey. Exp Eye Res. 3:31–35, 1964.PubMedCrossRefGoogle Scholar
  60. 60.
    Gilles FH, Davidson RI: Communicating hydrocephalus associated with deficient displastic parasagittal arachnoidal granulations. J Neurosurg 35:421–426, 1971.PubMedCrossRefGoogle Scholar
  61. 61.
    Gutierrez Y, Friede RL, Kaliney WJ: Agenesis of arachnoid granulations and its relationship to communicating hydrocephalus. J Neurosurg 23:553–558, 1975.CrossRefGoogle Scholar
  62. 62.
    Milhorat TH: Paediatric Neurosurgery. Davis, Philadelphia, 1978, pp. 91–135.Google Scholar
  63. 63.
    Schoene WC: The Nervous System. In Robbins SL: Pathologic basis of disease. Philadelphia, Saunders Company, 1979, pp. 1530–1598.Google Scholar
  64. 64.
    Mingrino S, Rigobello L, Scanarini M, et al.: Electron Microscopy of Human Arachnoid Villi removed during operation in different pathological conditions. In Ishii S, Nagai H, Brock M, eds: Intracranial Pressure V, Berlin/ Heidelberg/New York, Springer-Verlag, 1983, pp. 588–592.CrossRefGoogle Scholar
  65. 65.
    Thomas H: Licht-and elektronenmikroskopische Untersuchungen an den weichen Hirnhauten und den Pacchionischen Granulationen des Menschen. Z Mikrosk Anat Forsch 75:270, 1966.Google Scholar
  66. 66.
    Tripathi RC: Ultrastructure of the arachnoid mater in relation to outflow of cerebrospinal fluid: a new concept. Lancet II: 8–11, 1973.CrossRefGoogle Scholar
  67. 67.
    Alksne JF, White LE: ELectron microscope study of the effect of increased intracranial pressure on the arachnoid villus. J Neurosurg 22:481–488, 1965.PubMedCrossRefGoogle Scholar
  68. 68.
    Shabo AL, Maxwell DS: The morphology of the arachnoid villi: a light and electron microscopic study in the monkey. J Neurosurg 29:451–463, 1968.CrossRefGoogle Scholar
  69. 69.
    Gomez DG, Potts DG: The surface characteristics of arachnoid granulations: a scanning electron microscopical study. Arch Neurol 31:88–93, 1974.PubMedCrossRefGoogle Scholar
  70. 70.
    Cushing H: Studies on cerebrospinal fluid circulation. Am J Med Sci 124:72–86, 1902.CrossRefGoogle Scholar
  71. 71.
    Lorenzo AV, Page LK, Watters GV: Relationship between cerebrospinal fluid formation, absorption and pressure in human hydrocephalus. Brain 93:679–692, 1970.PubMedCrossRefGoogle Scholar
  72. 72.
    D’Avella D, Cicciarello R, Albiero F, et al.: Scanning electron microscope study of human arachnoid villi. J Neurosurg 59:620–626, 1983.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1993

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  • Luca Rigobello

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