Abstract
Positron Emission Tomography (PET) of the heart permits non-invasive identification of myocardial ischemia and infarction through metabolic and perfusion imaging. Ischemic tissue is characterized by reduced perfusion and appears as a defect when 13-N ammonia is used as the imaging agent because this tracer is taken up in the myocardium in proportion to blood flow (Schelbert et al., 1981). Within the ischemic zone, viable tissue can be differentiated from non-viable or infarcted tissue by the presence of persistent metabolic activity which can be imaged with 18-F deoxyglucose (18-FDG) (Schwaiger et al., 1985). Of particular clinical importance is the non-invasive measurement of the fraction of the total left ventricular (LV) volume which is infarcted or ischemic. We have developed two approaches to accurately recover the fraction of LV myocardium involved in the ischemic process directly from PET images of myocardial perfusion, metabolism, and the LV bloodpool.
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© 1988 Springer Science+Business Media New York
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Rowe, R.W., Merhige, M.E., Bendriem, B., Gould, K.L. (1988). Region of Interest Determination for Quantitative Evaluation of Myocardial Ischemia from PET Images. In: de Graaf, C.N., Viergever, M.A. (eds) Information Processing in Medical Imaging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7263-3_40
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DOI: https://doi.org/10.1007/978-1-4615-7263-3_40
Publisher Name: Springer, Boston, MA
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