Abstract
A dynamic radionuclide study provides a description of the way the administrated tracer behaves in the several separate structures in the body. The usual aim of dynamic study analysis is to attempt to isolate the information from one or more important structures from the rest of the study. Because of the way the images of structures overlap it is rarely possible to derive the variation of tracer concentration within a single structure directly from the dynamic study. The common approach to this problem is to define a region (a region-of-interest (ROI)) around the structure of interest and compute the curve representing the variation of activity within that region and then attempt to estimate and remove from this curve the contribution from the surrounding and overlapping structures (background structures). An estimate of this component of activity is usually obtained from a second ROI over a region in the study indicative of the background activity in the region of the structure of interest.
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References
Barber,D.C. (1980). The use of principal components in a quantitative analysis of gamma camera dynamic studies, Phys. Med. Biol. 25, 283–292.
Barber,D.C. and Nijran,K.S. (1981). Factor analysis of dynamic radionuclide studies, in: Information Processing in Medical Imaging, M.Goris (ed.), Univ. Stanford, Stanford, 13–28.
Bazin,J.P. and Di Paola,R. (1982). Advances in factor analysis application in dynamic function studies, in: Proc. 3rd World Congr. of Nuclear Medicine and Biology, C.Raynauld (ed.), Pergamon, Paris, Vol 1, 35–38.
Houston,A.S. (1986). The use of set theory and cluster analysis to investigate the constraint problem in factor analysis in dynamic structures (FADS), in: Information Processing in Medical Imaging, S.Bacharach (ed.), Martinus Nijhoff, 177–192.
Nijran,K.S. (1984). Analysis of dynamic radionuclide studies using principal components factor analaysis, Ph.D. thesis, University of Sheffield, Sheffield. Nijran,K.S. and Barber,D.C. ( 1984 ). Analysis of dynamic radionuclide studies using factor analysis-a new approach, in: Information processing in medical imaging, F.Deconinck (ed.), Martinus Nijhoff, 30–45.
Nijran,K.S. and Barber,D.C. (1986). Factor analysis of dynamic function studies using a priori physiological information, Phys. Med. Biol. 31, 1107–1117.
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© 1988 Springer Science+Business Media New York
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Nijran, K.S., Barber, D.C. (1988). The Importance of Constraints in Factor Analysis of Dynamic Studies. In: de Graaf, C.N., Viergever, M.A. (eds) Information Processing in Medical Imaging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7263-3_34
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DOI: https://doi.org/10.1007/978-1-4615-7263-3_34
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