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Cyclic Nucleotides, Arachidonic Acid, and Polyamines in the Pathophysiology of Inflammatory Proliferative Skin Diseases

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Immunodermatology

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

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Abstract

Psoriasis is a multifactorial genetic disease (Watson et al., 1972) in which a major feature is an exaggerated epidermal proliferation. Various disorders in immunodermatology such as allergic contact dermatitis and atopic dermatitis have increases of normal epithelial proliferation as a major feature of the lesion. At least at the level of current understanding, there is reason to assume that many of the described abnormal mechanisms in psoriatic epithelium will also be present in hyperplastic epidermis in general. This chapter will cover mechanisms of proliferation, using psoriasis as a model, with the idea that the knowledge may well pertain to epidermis stimulated to proliferate by immune injury.

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References

  • Anderson, W. B., and Jaworski, C. J., 1977, Modulation of adenylate cyclase activity of fibroblasts by free fatty acids and phospholipids, Arch. Biochem. Biophys. 180: 374–383.

    Article  PubMed  CAS  Google Scholar 

  • Anonymous, 1976, Cyclic AMP and dibutyryl AMP in treatment of psoriasis, Chin. Med. J. 2: 141–146.

    Google Scholar 

  • Aso, K., Deneau, D. G., Krulig, L., Wilkinson, D. I., and Farber, E. M., 1975a, Epidermal synthesis of prosta-glandins and their effect on levels of cyclic adenosine 3’,5’-monophosphate, J. Invest. Dermatol. 64: 326–331.

    Article  PubMed  CAS  Google Scholar 

  • Aso, K., Orenberg, E. K., and Farber, E. M., 1975b, Reduced epidermal cyclic AMP accumulation following prostaglandin stimulation: Its possible role in the pathophysiology of psoriasis, J. Invest. Dermatol. 65: 375–378.

    Article  PubMed  CAS  Google Scholar 

  • Baig, M. M., and Roberts, R. M., 1973, Comparative studies on the carbohydrate-containing membrane components of normal and adenosine 3’:5’-cyclic monophosphate-treated chinese-hamster ovary cells, Biochem. J. 134: 329–339.

    PubMed  CAS  Google Scholar 

  • Braun-Falco, O., 1958, The histochemistry of psoriasis, Ann. N.Y. Acad. Sci., 73: 936–976.

    PubMed  CAS  Google Scholar 

  • Bullough, W. S., and Laurence, E. B., 1964, Mitotic control by internal secretion: The role of the chalone-adrenalin complex, Exp. Cell Res. 33: 176–194.

    Article  PubMed  CAS  Google Scholar 

  • Carter, T. N., 1972, The relationship of lithium carbonate to psoriasis, Psychosomatics 13: 325–327.

    PubMed  CAS  Google Scholar 

  • Chopra, D. P., 1977, Effects of theophylline and dibutyryl cyclic AMP on proliferation and keratinization of human keratinocytes, Br. J. Dermatol. 96: 255–262.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, R. A., 1977, Abnormalities of cell-membrane fluidity in the pathogenesis of disease, N. Engl. J. Med. 297 (7): 371–377.

    Article  PubMed  CAS  Google Scholar 

  • Delescluse, C., Colburn, N. H., Duell, E. A., and Voorhees, J. J., 1974, Cyclic AMP-elevating agents inhibit proliferation of keratinizing guinea pig epidermal cells, Differentiation 2: 343–350.

    Article  PubMed  CAS  Google Scholar 

  • Delescluse, C., Fukuyama, K., and Epstein, W. L., 1976, Dibutyryl cyclic AMP-induced differentiation of epidermal cells in tissue culture, J. Invest. Dermatol. 66: 8–13.

    Article  CAS  Google Scholar 

  • Emmelot, P., 1973, Biochemical properties of normal and neoplastic cell surfaces; a review, Eur. J. Cancer 9: 319–333.

    Article  PubMed  CAS  Google Scholar 

  • Fillingame, R. H., Jorstad, C. M., and Morris, D. R., 1975, Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A, Proc. Natl. Acad. Sci. USA 72: 4042–4045.

    Article  PubMed  CAS  Google Scholar 

  • Flaxman, B. A., and Harper, R. A., 1975, In vitro analysis of the control of keratinocyte proliferation in human epidermis by physiologic and pharmacologic agents, J. Invest. Dermatol. 65: 52–59.

    CAS  Google Scholar 

  • Fraki, J. E., and Hopsu-Havu, V. K., 1976, Plasminogen activator and histone hydrolyzing proteases in psoriasis scales—Possible role in increased cell division, Ann. Clin. Res. 8: 335–339.

    PubMed  CAS  Google Scholar 

  • Friedman, D. L., 1976, Role of cyclic nucleotides in cell growth and differentiation, Physiol. Rev. 56: 652–708.

    CAS  Google Scholar 

  • Goetzl, E. J., Woods, J. M., and Gorman, R. R., 1977, Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, J. Clin, Invest. 59: 179–183.

    Article  CAS  Google Scholar 

  • Goldberg, N. D., and Haddox, M. K., 1977, Cyclic GMP metabolism and involvement in biological regulation, Annu. Rev. Biochem. 46: 823–896.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin, P., Hamilton, S., and Frey, L., 1973, A comparison between DNA synthesis and mitosis in unin-volved and involved psoriatic epidermis and normal epidermis, Br. J. Dermatol. 89: 613–618.

    Article  PubMed  CAS  Google Scholar 

  • Hadden, J. W., Hadden, E. M., Haddox, M. K., and Goldberg, N. D., 1972, Guanosine 3’:5’-cyclic mono-phosphate: A possible intracellular mediator of mito-genic influences in lymphocytes, Proc. Natl. Acad. Sci. USA 69: 3024–3027.

    Article  PubMed  CAS  Google Scholar 

  • Hammarström, S., Hamberg, M., Samuelsson, B., Duell, E. A., Stawiski, M., and Voorhees, J. J., 1975, Increased concentrations of nonesterified arachidonic acid, 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2 and prostaglandin F2ain epidermis of psoriasis, Proc. Natl. Acad. Sci. USA 72: 5130–5134.

    Article  PubMed  Google Scholar 

  • Härkönen, M., Hopsu-Havu, V. K., and Raij, K., 1974, Cyclic adenosine monophosphate, adenyl cyclase and cyclic nucleotide phosphodiesterase in psoriatic epidermis, Acta Derm. Venereol. 54: 13–18.

    Google Scholar 

  • Hidaka, H., and Asano, T., 1977, Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides, Proc. Natl. Acad. Sci. USA 74: 3657–3661.

    Article  PubMed  CAS  Google Scholar 

  • Insel, P. A., and Fenno, J., 1978, Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosyl-methionine decarboxylase activities, Proc. Natl. Acad. Sci. USA 75: 862–865.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, G. S., and Pastan, I., 1971, Change in growth and morphology of fibroblasts by prostaglandins, J. Natl. Cancer Inst. 47: 1357–1364.

    PubMed  CAS  Google Scholar 

  • Kassis, V., Weismann, K., Heiligstädt, H., and Söndergaard, J., 1977, Synthesis of prostaglandins by psoriatic skin, Arch. Dermatol. Res. 259: 207–212.

    Article  PubMed  CAS  Google Scholar 

  • Lapetina, E. G., Schmitges, C. J., Chandrabose, K., and Cuatrecasas, P., 1977, Cyclic adenosine 3’,5’-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets, Biochem. Biophys. Res. Commun. 76: 828–835.

    Article  PubMed  CAS  Google Scholar 

  • Mahrle, G., and Orfanos, C. E., 1975, R-Adrenerge Stimulation membrangebundener Adenylcyklase in normaler Epidermis and mangelnde Stimulierbarkeit bei Psoriasis, Arch. Dermatol. Res. 253: 195–202.

    Article  PubMed  CAS  Google Scholar 

  • Mahrle, G., and Orfanos, C. E., 1977, The plasma unit membrane, Br. J. Dermatol. 96: 215–223.

    Article  PubMed  CAS  Google Scholar 

  • Mamont, P. S., Böhlen, P., McCann, P. P., Bey, P., Schuber, F., and Tardif, C., 1976, a-Methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture, Proc. Natl. Acad. Sci. USA 73: 1626–1630.

    Google Scholar 

  • Marcelo, C. L., Duell, E. A. and Voorhees, J. J., 1978, Cyclic nucleotide levels in psoriatic and normal populations, in: Advances in Cyclic Nucleotide Research ( W. George, L. Ignarro, G. A. Robison, and P. Greengard, eds.), Raven Press, New York.

    Google Scholar 

  • McMichael, A. J., Morhenn, V., Payne, R., Sasazuki, T., and Farber, E. M., 1978, HLA C and D antigens associated with psoriasis, Br. J. Dermatol. 98: 287–292.

    Article  PubMed  CAS  Google Scholar 

  • Meruelo, D., and Edidin, M., 1975, Association of mouse liver adenosine 3’:5’-cyclic monophosphate (cyclic AMP) leveles with histocompatibility-2 genotype, Proc. Natl. Acad. Sci. USA 72: 2644–2648.

    Article  PubMed  CAS  Google Scholar 

  • Minkes, M., Stanford, N., Chi, M. M.-Y., Roth, G. J., Raz, A., Needleman, P., and Majerus, P. W., 1977, Cyclic adenosine 3’,5’-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions, J. Clin. Invest. 59: 449–454.

    Article  PubMed  CAS  Google Scholar 

  • Muller, W. E. G., Muller, I., Zahn, R. K., and Kurelec, B., 1978, Species-specific aggregation factor in sponges, Cell Tissue Kinet. 11: 23–32.

    PubMed  CAS  Google Scholar 

  • Nesbitt, J. A., Anderson, W. B., Miller, Z., Pastan, I., Russell, T. R., and Gospodarowicz, D., 1976, Guanylate cyclase and cyclic guanosine 3’:4’-monophosphate phosphodiesterase activities and cyclic guanosine 3’:5’monophosphate levels in normal and transformed fibroblasts in culture, J. Biol. Chem. 251: 2344–2352.

    PubMed  CAS  Google Scholar 

  • Newcombe, D. S., Ciosek, C. P., Jr., Ishikawa, Y., and Fahey, J. V., 1975, Human synoviocytes: Activation and desensitization by prostaglandins and l-epinephrine, Proc. Natl. Acad. Sci. USA 72: 3124–3128.

    Article  PubMed  CAS  Google Scholar 

  • Penneys, N. S., Ziboh, V., Lord, J., and Simon, P., 1975, Ihibitor(s) of prostaglandin synthesis in psoriatic plaque, Nature (London) 254: 351–352.

    Article  CAS  Google Scholar 

  • Penneys, N. S., Simon, P., Ziboh, V. A., and Schlossberg, J., 1977, In vivo chemotaxis induced by polyunsaturated fatty acids, J. Invest. Dermatol. 69: 435–438.

    CAS  Google Scholar 

  • Posternak, F., Posternak, T., Orusco, M., Cehovic, G., and Laugier, P., 1976, Essais de traitement du psoriasis par injections intra-lésionnelles d’AMPc, de dibutyryl8-thin AMPc, et de théophylline, Journ. Nat. Dermatol. 103: 640–644.

    CAS  Google Scholar 

  • Puck, T. T., 1977, Cyclic AMP, the microtubule-microfilament system, and cancer, Proc. Natl. Acad. Sci. USA 74: 4491–4495.

    Article  PubMed  CAS  Google Scholar 

  • Ramwell, P. W., Leovey, E. M. K., and Sintetos, A. L., 1977, Regulation of the arachidonic acid cascade, Biol. Reprod. 16: 70–87.

    Article  PubMed  CAS  Google Scholar 

  • Russell, D. H., and Stambrook, P. J., 1975, Cell cycle specific fluctuations in adenosine 3’:5’-cyclic mono-phosphate and polyamines of chinese hamster cells, Proc. Natl. Acad. Sci. USA 72: 1482–1486.

    Article  PubMed  CAS  Google Scholar 

  • Russell, D. H., Combest, W. L., Duell, E. A., Stawiski, M. A., Anderson, T. F., and Voorhees, J. J., 1978, Glucocorticoid inhibits elevated polyamine biosynthesis in psoriasis, J. Invest. Dermatol. 71: 177–181.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, C., Penneys, N. S., Ziboh, V. A., Kiem, I., and Schlossberg, J., 1977, Cholesterol and cholesteryl ester content in normal and pathologic scale, J. Invest. Dermatol. 68: 206–209.

    Article  PubMed  CAS  Google Scholar 

  • Shier, W. T., 1977, Inhibition of prostaglandin synthesis of lysolecithin, Biochem. Biophys. Res. Commun. 78: 1168–1174.

    Article  CAS  Google Scholar 

  • Shier, W. T., Baldwin, J. H., Nilsen-Hamilton, M., Hamilton, R. T., and Thanassi, N. M., 1976, Regulation of guanylate and adenylate cyclase activities by lysolecithin, Proc. Natl. Acad. Sci. USA 73: 1586–1590.

    Article  PubMed  CAS  Google Scholar 

  • Skott, A., Mobacken, H., and Starmark, J. E., 1977, Exacerbation of psoriasis during lithium treatment, Br. J. Dermatol. 96: 445–448.

    Article  PubMed  CAS  Google Scholar 

  • Sondergaard, J., Wadskov, S., Jensen, H. A. E., and Mikkelsen, H. I., 1976, Aggravation of psoriasis and occurrence of psoriasiform cutaneous eruptions in-duced by practolol (Eraldin°), Acta Derm, Venereol. 56: 239–243.

    CAS  Google Scholar 

  • Stankler, L., 1977, Histological findings in clinically normal palmer skin of patients with psoriasis, Br. J. Dermatol. 97: 131–134.

    Article  PubMed  CAS  Google Scholar 

  • Stawiski, M. A., Powell, J. A., Lang, P. G., Schork, A., Duell, E. A., and Voorhees, J. J., 1975, Papaverine: Its effects on cyclic AMP in vitro and psoriasis in vivo, J. Invest. Dermatol. 64: 124–127.

    Article  PubMed  CAS  Google Scholar 

  • Stawiski, M., Rusin, L., Schork, M. A., Burns, T., Duell, E., and Voorhees, J., 1976, Ro-20–1724 elevates epidermal cyclic AMP levels in vitro and improves psoriasis in vivo, Clin. Res. 24: 267.

    Google Scholar 

  • Sutherland, E. W., and Rail, T. W., 1960, The relation of adenosine-3’,5’-phosphate and phosphorylase to the actions of catecholamines and other hormones, Pharmacol. Rev. 12: 265–299.

    CAS  Google Scholar 

  • Truding, R., and Morel!, P., 1977, Effect of N6,02’-dibutyryl adenosine 3’:5’-monophosphate on the release of surface proteins by murine neuroblastoma cells, J. Biol. Chem. 252: 4850–4854.

    PubMed  CAS  Google Scholar 

  • Turner, S. R., Tainer, J. A., and Lynn, W. S., 1975, Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets, Nature (London) 257: 680–681.

    Article  CAS  Google Scholar 

  • Vassalli, J.-D., Hamilton, J., and Reich, E., 1976, Macrophage plasminogen activator: Modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides, Cell 8: 271–281.

    Article  PubMed  CAS  Google Scholar 

  • Voorhees, J. J., and Duell, E. A., 1971, Psoriasis as a possible defect of the adenyl cyclase-cyclic AMP cascade: A defective chalone mechanism? Arch. Dermatol. 104: 352–358.

    Article  PubMed  CAS  Google Scholar 

  • Voorhees, J. J., Duell, E. A., Bass, L. J., Powell, J. A., and Harrell, E. R., 1972, Decreased cyclic AMP in the epidermis of lesions of psoriasis, Arch. Dermatol. 105: 695–701.

    CAS  Google Scholar 

  • Voorhees, J. J., Duell, E. A., Stawiski, M., and Harrell, E. R., 1974a, Cyclic nucleotide metabolism in normal and proliferating epidermis, in: Advances in Cyclic Nucleotide Research, Vol. 4 ( P. Greengard and G. A. Robison, eds.), pp. 117–162, Raven Press, New York.

    Google Scholar 

  • Voorhees, J. J., Colburn, N. H., Stawiski, M., Duell, E. A., Haddox, M., and Goldberg, N. D., 1974b, Imbalanced cyclic AMP and cyclic GMP levels in the rapidly dividing, incompletely differentiated epidermis of psoriasis, in: Control of Proliferation in Animal Cells ( B. Clarkson and R. Baserga, eds.), pp. 635–648, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.

    Google Scholar 

  • Voorhees, J. J., Marcelo, C. L., and Duell, E. A., 1975, Cyclic AMP, cyclic GMP, and glucocorticoids as potential metabolic regulators of epidermal proliferation and differentiation, J. Invest. Dermatol. 65: 179–190.

    Article  PubMed  CAS  Google Scholar 

  • Voorhees, J. J., Duell, E. A., Anderson, T. F., Stawiski, M. A., Hammarström, S., and Hamberg, M., 1978, Pharmacological effects of glucocorticoid on arachidonic acid content of lesions of psoriasis, in: Advances in Prostaglandin and Thromboxane Research, Vol. 3 ( C. Galli, B. Samuelsson, and R. Paoletti, eds.), pp. 175–181, Raven Press, New York.

    Google Scholar 

  • Wallach, D., and Pastan, 1., 1976, Stimulation of guanylate cyclase of fibroblasts by free fatty acids, J. Biol. Chem. 251: 5802–5809.

    PubMed  CAS  Google Scholar 

  • Wang, Y.-C., Pandey, G. N., Mendels, J., and Frazer, A., 1974, Effect of lithium on prostaglandin El-stimulated adenylate cyclase activity of human platelets, Biochem. Ph armacol. 23: 845–855.

    CAS  Google Scholar 

  • Wanger, L., and Sundqvist, K.-G., 1978, Membrane-associated actin in psoriatic epidermis, Acta Derm. Venereal. 58: 79–82.

    CAS  Google Scholar 

  • Watson, W., Cann, H. M., Farber, E. M., and Nall, M. L., 1972, The genetics of psoriasis, Arch. Dermatol. 105: 197–207.

    Article  PubMed  CAS  Google Scholar 

  • Weinstein, G. D., and Frost, P., 1968, Abnormal cell pro- liferation in psoriasis, J. Invest. Dermatol. 50: 254–259.

    PubMed  CAS  Google Scholar 

  • Whittenberger, B., and Glaser, L., 1977, Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes, Proc. Natl. Acad. Sci. USA 74: 2251–2255.

    Article  PubMed  CAS  Google Scholar 

  • Wiley, H., and Weinstein, G., 1977, Selective proliferative abnormality induced by propranolol in uninvolved psoriatic skin compared to normal skin, J. Invest. Dermatol. 68: 239.

    Google Scholar 

  • Yoshikawa, K., Adachi, K., Halprin, K. M., and Levine, V., 1975a, On the lack of response to catecholamine stimulation by the adenyl cyclase system in psoriatic lesions, Br. J. Dermatol. 92: 619–624.

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa, K., Adachi, K., Halprin, K. M., and Levine, V., 1975b, Is the cyclic AMP in psoriatic epidermis low? Br. J. Dermatol. 93: 253–258.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA

    John J. Voorhees

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  1. John J. Voorhees
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  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

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© 1981 Plenum Publishing Corporation

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Voorhees, J.J. (1981). Cyclic Nucleotides, Arachidonic Acid, and Polyamines in the Pathophysiology of Inflammatory Proliferative Skin Diseases. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_9

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  • DOI: https://doi.org/10.1007/978-1-4615-7228-2_9

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