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Humoral Immunity in Comprehensive Immunology

  • Chapter
Immunodermatology

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

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Abstract

Humoral immunity generally is regarded as that part of the immunological defense system which is mediated by the immunoglobulins. Although full humoral immunocompetence depends also on the biological amplification system, the complement proteins, the immunoglobulins are the primary mediators of humoral defense. The immunoglobulins are a widely heterogeneous range of chemically related glycoprotein macromolecules which normally possess antibody activity, i.e., the ability to combine specifically with an antigen. The classes of molecules differ from each other in specific structure, biological activities, and distribution in blood and tissue fluids, but all are products of activated lymphocytes or plasma cells, and all have certain common general structural features. The first part of this chapter presents the chemical similarities and differences of the classes of immunoglobulin molecules and discusses the biological role each is known to play in the humoral immune response. After this, the subjects of B-cell activation and immunoglobulin synthesis and immunoglobulin evolution are considered.

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  1. Immunobiology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Charlotte Cunningham-Rundles

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  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

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Cunningham-Rundles, C. (1981). Humoral Immunity in Comprehensive Immunology. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_3

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  • DOI: https://doi.org/10.1007/978-1-4615-7228-2_3

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