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Autoimmunity

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Book cover Immunodermatology

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

Abstract

At the turn of the twentieth century, Ehrlich contrasted the ease of inducing antibodies to foreign cells. Ehrlich and Morgenroth (1900) showed that serum from goats immunized with blood from other goats would lyse erythrocytes from those goats but not autologous erythrocytes. These authors concluded, “the organism has contrivances by which the immunity reaction ... is prevented from reacting against the organism’s own elements.” Thus the genesis of the concept of “horror autotoxicus.”

This work was supported in part by USPHS Grants AG 00541, CA 13339, AG 00239, and AG 00681. Marc E. Weksler is the recipient of USPHS Research Career Development Award CA 32102.

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Authors and Affiliations

  1. Department of Medicine, Cornell University Medical College, New York, New York, 10021, USA

    Edmond A. Goidl & Marc E. Weksler

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  1. Edmond A. Goidl
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  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

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Goidl, E.A., Weksler, M.E. (1981). Autoimmunity. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_20

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