Skip to main content
SpringerLink
Log in
Book cover

Immunodermatology pp 293–299Cite as

Eosinophil in Skin Disorders

  • Chapter

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

Abstract

Eosinophils have received increasing attention from dermatologists over the years as the association of eosinophilia with several skin diseases has become more generally realized. Described as early as 1879, eosinophils have since proved to be associated with allergic, parasitic, and neoplastic disorders. Dermatologists were among the first physicians to recognize the importance of this association; patients with cutaneous disease occasionally show highly increased numbers of eosinophils, either in inflammatory infiltrates or in the circulation or both.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alexander, J. D., 1961, Is eosinophilia of diagnostic importance in dermatitis herpetiforms? Br. J. Dermatol. 73: 267–272.

    Article  PubMed  CAS  Google Scholar 

  • Allen, A. C., 1948, Persistent “insect bites” (dermal eosinophilic granulomas) simulating lymphoblastomas, histiocytoses, and squamous cell carcinomas, Am. J. Pathol. 24: 367–387.

    PubMed  CAS  Google Scholar 

  • Archer, R. K., 1960, Eosinophil leukocyte attracting effect of histamine in skin, Nature 187: 155–156.

    Article  PubMed  CAS  Google Scholar 

  • Atkins, P., Green, G. R., and Zweiman, B., 1973, Influx of eosinophils as consequence of IgE dependent reactions, J. Allergy Clin. Immunol. 51: 263–273.

    Article  PubMed  CAS  Google Scholar 

  • Baehner, R., and Johnston, R. B., 1971, Metabolic and bactericidal activities of human eosinophils, Br. J. Haematol. 20: 277–285.

    Article  PubMed  CAS  Google Scholar 

  • Basten, A., and Beeson, P. B., 1970, Mechanisms of eosinophilia. II. Role of the lymphocyte, J. Exp. Med. 131: 1288–1305.

    Article  PubMed  CAS  Google Scholar 

  • Basten, A., Boyer, M. H., and Beeson, P. B., 1970, Mechanism of eosinophilia. I. Factors affecting the eosinophil response of rats to Trichinella spiralis, J. Exp. Med. 131: 1271–1287.

    Article  PubMed  CAS  Google Scholar 

  • Beeson, P. B., and Bass, D. A., 1977, The Eosinophil, Vol. 14, Philadelphia, Saunders, New York.

    Google Scholar 

  • Boyer, M. H., Basten, A., and Beeson, P. B., 1970, Mechanism of eosinophilia. III. Suppression of eosinophilia by agents known to modify immune responses, Blood 36: 458–469.

    PubMed  CAS  Google Scholar 

  • Butterworth, A. E., Sturrock, R. F., Houba, V., Mah-moud, A. A. F., Sher, A., and Rees, P. H., 1975, Eosinophils as mediators of antibody-dependent damage to schistosomula, Nature (London) 256: 727–729.

    Article  CAS  Google Scholar 

  • Butterworth, A. E., David, J. R., Franks, D., Mahmoud, A. A. F., David, P. H., Sturrock, R. F., and Houba, V., 1977, Antibody-dependent eosinophil-mediated damage to 51Cr-labelled schistosomula of Schistosoma man-soni: Damage by purified eosinophils, J. Exp. Med. 145: 136–150.

    Article  PubMed  CAS  Google Scholar 

  • Clark, R. A. F., Gatlin, J. I., and Kaplan, A. P., 1975, The selective eosinophil chemotactic activity of histamine, J. Exp. Med. 142:1462–1476.

    Google Scholar 

  • Colley, D. G., 1973, Eosinophils and immune mechanisms. I. Eosinophil stimulation promotor (ESP): A lymphokine induced by specific antigen or phytohemagglutinin, J. Immunol. 110:1419–1423.

    Google Scholar 

  • Colley, D. G., 1975, Immune responses to a soluble schistosomal egg antigen preparation during chronic primary infection with Schistosoma mansoni, J. Immunol. 115: 150–156.

    PubMed  CAS  Google Scholar 

  • Dale, D. C., Hubert, R., and Fauci, A. S., 1976, Eosinophil kinetics in the hypereosinophil syndrome, J. Lab. Clin. Med. 87: 487–495.

    CAS  Google Scholar 

  • Eidinger, D., Wilkinson, R., and Rose, B., 1964, A study of cellular responses in immune reactions utilizing the skin window technique, J. Allergy 35: 77–85.

    Article  PubMed  CAS  Google Scholar 

  • El-Hashimi, W., 1971, Charcot-Leyden crystals—Formation from primate and lack of formation from nonprimate eosinophils, Am. J. Pathol. 65: 311–324.

    PubMed  CAS  Google Scholar 

  • Faller, A., 1966, Zur Frage von Struktur und Aufbau der Eosinophilen Granula, Z. Zellforsch. Mikrosk. Anat. 69: 551–565.

    Article  PubMed  CAS  Google Scholar 

  • Feinberg, A. R., Feinberg, S. M., and Lee, F., 1967, Leukocytes and hypersensitivity reactions: Eosinophil response in skin windows to ragweed extracts, histamine and compound 48/80 in atopic and non-atopic individuals, J. Allergy 40: 73–87.

    Article  PubMed  CAS  Google Scholar 

  • Gleich, G. J., Loegering, D. A., and Maldonado, J. E., 1973, Identification of a major basic protein in guinea pig eosinophil granules, J. Exp. Med. 137:1459–1471.

    Google Scholar 

  • Gleich, G. J., Loegering, D. A., Mann, K. G., and Maldonado, J. E., 1976, Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils, J. Clin. Invest. 57: 633640.

    Google Scholar 

  • Goetzl, E. J., Wasserman, S. I., and Austen, K. F., 1974, Modulation of the Eosinophil Chemotactic Response in Immediate Hypersensitivity, (L. Brent and J. Holborow, eds.), pp. 41–50, North-Holland, Amsterdam.

    Google Scholar 

  • Gross, R., 1962, The eosinophils, in: The Physiology and Pathology of Leukocytes (H. Braunsteiner and D. Zucker-Franklin, eds.), pp. 1–46, Grune and Stratton, New York.

    Google Scholar 

  • Higashi, G. I., and Chowdhury, A. B., 1970, In vitro adhesion of eosinophils to infective larvae of Wuchereria bancrofti, Immunology 19: 65–83.

    PubMed  CAS  Google Scholar 

  • Hubscher, T., 1975, Role of the eosinophil in the allergic reactions. I. EDI—An eosinophil-derived inhibitor of histamine release, J. Immunol. 114: 1379–1388.

    PubMed  CAS  Google Scholar 

  • Kay, A. B., and Austen, K. F., 1971, The IgE-mediated release of an eosinophil leukocyte chemotactic factor from human lung, J. Immunol. 107: 889–902.

    Google Scholar 

  • Kay, A. B., Stechschulte, D. J., and Austen, K. F., 1971, An eosinophil leukocyte chemotactic factor of anaphylaxis, J. Exp. Med. 133: 602–619.

    Article  PubMed  CAS  Google Scholar 

  • Klebanoff, S. J., Durack, D. T., Rosen, H., and Clark, R. A., 1977, Functional studies on human peritoneal eosinophils, Infect. Immun. 17: 167–173.

    PubMed  CAS  Google Scholar 

  • Mahmoud, A. A. F., Warren, K. S., and Peters, P. A., 1975, A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum, J. Exp. Med. 142: 805–813.

    Article  PubMed  CAS  Google Scholar 

  • O’Loughlin, S., Diaz-Perez, J. L., Gleich, G. J., and Winkelmann, R. K., 1977, Serum IgE in dermatitis and dermatosis: An analysis of 497 cases, Arch. Dermatol. 113: 309.

    Article  PubMed  Google Scholar 

  • Olsson, I., PerVenge, Spitznagel, J. K., and Lehrer, R. I., 1977, Arginine-rich cationic proteins of human eosinophil granules, Lab. Invest. 36: 493–500.

    PubMed  CAS  Google Scholar 

  • Parish, W. E., 1972, Eosinophilia. II. Cutaneous eosinophilia in guinea pigs mediated by passive anaphylaxis with IgGI or reagin, and antigen-antibody complexes; its relation to neutrophils and to mast cells, Immunology 23: 19–34.

    PubMed  CAS  Google Scholar 

  • Pinkus, H., 1951, Granulomas with eosinophilia (“eosinophilic granulomas”), Med. Clin. North Am. 35: 463479.

    Google Scholar 

  • Schaefer, H. E., Hubner, G., and Fischer, R., 1973, Spezifische Microgranula in Eosinophilen, Acta Haematol. 50: 92–104.

    Article  PubMed  CAS  Google Scholar 

  • Stenger, R. J., Warren, K. S., and Johnson, E. A., 1967, An ultrastructural study of hepatic granulomas and schistosome egg shells in murine hepatosplenic Schistosomiasis mansoni, Exp. Mol. Pathol. 7: 116–132.

    Article  PubMed  CAS  Google Scholar 

  • Taliaferro, W. H., and Sarles, M. P., 1939, The cellular reactions in the skin, lungs and intestine of normal and immune rats after infection with Nippostrongylus muris, J. Infect. Dis. 54: 157–192.

    Article  Google Scholar 

  • Tanaka, K. R., Valentine, W. N., and Fredricks, R. E., 1962, Human leukocyte aryl sulphatase activity, Br. J. Haematol. 8: 86–92.

    Article  PubMed  CAS  Google Scholar 

  • Vercauteren, R., 1953, The properties of the isolate gran- ules from blood eosinophils, Enzymologia 16: 1–13.

    PubMed  CAS  Google Scholar 

  • Von Lichtenberg, F., Sher, A., Gibbons, N., and Doughty, B. L., 1976, Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni, Am. J. Pathol. 84: 479492.

    Google Scholar 

  • Ward, J. M., Wright, J. F., and Wharran, G. H., 1972, Ultrastructure of granulocytes in the peripheral blood of the cat. J. Ultrastruct. Res. 39:389–3%.

    Google Scholar 

  • Wasserman, S. I., Goetz!, E. J., and Austen, K. F., 1975, Inactivation of slow reacting substance of anaphylaxis of human eosinophil arylsufatase, J. Immunol. 114: 645649.

    Google Scholar 

  • Welsh, R. A., 1959, The genesis of the Charcot-Leyden crystal in the eosinophilic leukocyte of man, Am. J. Pathol. 35: 1091–1103.

    PubMed  CAS  Google Scholar 

  • Zucker-Franklin, D., 1974, Eosinophil function and disor-ders, Adv. Int. Med. 19:1–25.

    Google Scholar 

  • Zucker-Franklin, D., 1978, The properties of eosinophils, in: Immediate Hypersensitivity: Modern Concepts and Developments ( M. K. Back, ed.), pp. 407–430, Dekker, New York.

    Google Scholar 

  • Zucker-Franklin, D., and Hirsch, J. G., 1964, Electron microscope studies on the degranulation of rabbit peritoneal leukocytes during phagocytosis, J. Exp. Med. 120: 569–575.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, New York University Medical Center, New York, New York, 10016, USA

    Dorothea Zucker-Franklin

Authors
  1. Dorothea Zucker-Franklin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Publishing Corporation

About this chapter

Cite this chapter

Zucker-Franklin, D. (1981). Eosinophil in Skin Disorders. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7228-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7230-5

  • Online ISBN: 978-1-4615-7228-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation