Skip to main content
SpringerLink
Log in

Urticaria/Angioedema

The Mast Cell, Its Diverse Mediators, and Its Role in Cutaneous Inflammation

  • Chapter
Immunodermatology

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

  • 181 Accesses

Abstract

An immediate type of immunological reaction, termed type I, anaphylactic, or mast-cell-dependent hypersensitivity (Gell and Coombs, 1963), results from the antigen-induced release of biologically active materials from mast cells sensitized with specific IgE antibody. In humans, the clinical symptom complex occurs rapidly after the exposure of a sensitive individual to the appropriate antigen. The sites of clinical expressions include the skin (urticaria/angioedema), the respiratory and gastrointestinal tracts, and the cardiovascular system; these sites may be involved singly or in any combination. Similar clinical syndromes may occur after direct nonimmunological mast cell degranulation or in association with abnormalities of the complement pathways or the arachidonic acid-prostaglandin systems. In the latter two circumstances, it is likely that the chemical mediators are wholly or in part distinct from mast cell sources.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agnello, V., Koffler, D., Eisenberg, J. W., Winchester, R. J., and Kunkel, H. G., 1971, Clq precipitins in the sera of patients with systemic lupus erythematosus and other hypocomplementemic states: Characterization of high and low molecular weight types, J. Exp. Med 134: 228s - 241s.

    PubMed  CAS  Google Scholar 

  • Anwar, A. R. E., and Kay, A. B., 1977, The ECF-A tetrapeptides and histamine selectively enhance human eosinophil complement receptors, Nature 269: 522–524.

    Article  PubMed  CAS  Google Scholar 

  • Arroyave, C. M., and Tan, E. M., 1977, Mechanism of complement activation by radiographic contrast media, Clin. Exp. Immunol 29: 89–94.

    PubMed  CAS  Google Scholar 

  • Arroyave, C. M., Bhat, K. N., and Crown, R., 1976, Activation of the alternative pathway of the complement system by radiographic contrast media, J. Immu-nol 117: 1866–1869.

    CAS  Google Scholar 

  • Arroyave, C. M., Stevenson, D. D., Vaughan, J. H., and Tan, E. M., 1977, Plasma complement changes during bronchospasm provoked in asthmatic patients, Clin. Allergy 7: 173–182.

    Article  PubMed  CAS  Google Scholar 

  • Arroyave, C. M., Schatz, M., and Simon, R. A., 1979, Activation of the complement system by radiographic contrast media: Studies in vivo and in vitro, J. Allergy Clin. Immunol 63: 276–280.

    Article  PubMed  CAS  Google Scholar 

  • Assem, E. S. K., and Mongar, J. L., 1970, Inhibition of allergic reactions in man and other species by cromoglycate, Int. Arch. Allergy Appl. Immunol 38: 68–77.

    Article  PubMed  CAS  Google Scholar 

  • Atkins, P. C., Norman, M., Weiner, H., and Zweiman, B., 1977, Release of neutrophil chemotactic activity during immediate hypersensitivity reactions in humans, Ann. Intern. Med 86: 415–418.

    PubMed  CAS  Google Scholar 

  • Atkins, P. C., Weiner, H., Norman, M., and Zweiman, B., 1978, Antigen induced neutrophil chemotactic activity in man, J. Allergy Clin. Immunol 62: 149–155.

    Article  PubMed  CAS  Google Scholar 

  • Austen, K. F., Wasserman, S. I., and Goetz!, E. J., 1976, Mast cell-derived mediators: Structural and functional diversity and regulation of expression, in: Molecular and Biological Aspects of the Acute Allergic Reaction ( S. G. O. Johansson, K. S. Strandberg, and B. Uvnas, eds.), pp. 293–320, Plenum Press, New York.

    Chapter  Google Scholar 

  • Bach, M. K., Brashler, J. R., and Gorman, R. R., 1977, On the structure of slow reacting substance of anaphylaxis: Evidence of biosynthesis from arachidonic acid, Prostaglandins 14: 21–38.

    Article  PubMed  CAS  Google Scholar 

  • Ballow, M., Ward, G. W., Jr., Gerschwin, M. E., and Day, N. K., 1975, Cl-bypass complement-activation pathway in patients with chronic urticaria and angiooedema, Lancet 2: 248–250.

    Article  PubMed  CAS  Google Scholar 

  • Barnard, J. H., 1973, Studies of 400 hymenoptera sting deaths in the United States, J. Allergy Clin. Immunol 52: 259–264.

    Article  PubMed  CAS  Google Scholar 

  • Bayaral, M., Orgel, H. A., and Hamburger, R. N., 1974, Genetics of IgE and allergy: Serum IgE levels in twins, J. Allergy Clin. Immunol 54: 288–304.

    Article  Google Scholar 

  • Becker, E. L., 1968, Nature and significance of antigen-antibody activated esterases, in: Biochemistry of the Acute Allergic Reactions (K. F. Austen and E. L. Becker, eds.), pp. 199–213, Blackwell, Oxford.

    Google Scholar 

  • Benveniste, J., 1974, Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils, Nature (London) 249: 581–582.

    Article  CAS  Google Scholar 

  • Bhat, K. N., Arroyave, C. M., Marney, S. R., Stevenson, D. D., and Tan, E. M., 1976, Plasma histamine changes during provoked bronchospasm in asthmatic patients, J. Allergy Clin. Immunol 58: 647–656.

    Article  PubMed  CAS  Google Scholar 

  • Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R., and Parsons, E. M., 1972, Definition and antagonism of histamine H2-receptors, Nature (London) 236: 385–390.

    Article  CAS  Google Scholar 

  • Boswell, R. N., Austen, K. F., and Goetzl, E. J., 1978, Intermediate molecular weight eosinophil chemotactic factors in rat peritoneal mast cells: Immunologic release, granule association, and demonstration of structural heterogeneity, J. Immunol 120: 15–20.

    PubMed  CAS  Google Scholar 

  • Brasch, R. C., Rochoff, S. D., Kuhn, C., and Chraplyvy, M., 1970, Contrast media as histamine releasers, Invest. Radio!. 5: 510–513.

    Google Scholar 

  • Brocklehurst, W. E., 1960, The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock, J. Physiol. (London) 151: 416–435.

    CAS  Google Scholar 

  • Brocklehurst, W. E., 1962, Slow reacting substance and related compounds, Progr. Allergy 6: 539–558.

    CAS  Google Scholar 

  • Bruce-Pearson, B. S., 1963, Hypersensitivity to aspirin, in: Salicylates (A. Dixon and K. B. Martin, eds.), pp. 170–173, Churchill, London.

    Google Scholar 

  • Caldwell, J. R., Ruddy, S., Schur, P. H., and Austen, K. F., 1972, Acquired CT inhibitor deficiency in lymphosarcoma, Clin. Immunol. Immunopathol 1: 39–52.

    Article  Google Scholar 

  • Caulfield, J. P., Lewis, R. A., Hein, A., and Austen, K. F., 1980, Secretion in dissociated human pulmonary mast cells: Involvement of intermediate filaments and evidence for solubilization of granule contents before discharge, J. Cell Biol 85: 299–312.

    Article  PubMed  CAS  Google Scholar 

  • Center, D. M., Wasserman, S. I., Soter, N. A., and Austen, K. F., 1977, In vivo deactivation of human neutrophils to a subsequent in vitro stimulus, Clin. Res 25: 355A.

    Google Scholar 

  • Chafee, F. H., and Settipane, G. A., 1974, Aspirin intolerance. I. Frequency in an allergic population, J. Allergy Clin. Immunol 53: 193–199.

    Article  Google Scholar 

  • Champion, R. H., and Lachmann, P. J., 1969, Hereditary angio-oedema treated with e-aminocaproic acid, Br. J. Dermatol 81: 763–765.

    Article  PubMed  CAS  Google Scholar 

  • Champion, R. H., Roberts, S. O. B., Carpenter, R. G., and Roger, J. H., 1969, Urticaria and angio-oedema: A review of 554 patients, Br. J. Dermatol 81: 588–597.

    Article  PubMed  CAS  Google Scholar 

  • Christian, C. L., 1960a, Studies of aggregated}(-globulin. I. Sédimentation, electrophoretic and anticomplementary properties, J. Immunol 84: 112–116.

    PubMed  CAS  Google Scholar 

  • Christian, C. L., 1960b, Studies of aggregatedY-globulin. II. Effect in vivo, J. Immunol 84: 117–121.

    PubMed  CAS  Google Scholar 

  • Clark, R. A. F., Gallin, J. I., and Kaplan, A. P., 1975, The selective eosinophil chemotactic activity of histamine, J. Exp. Med 142: 1462 - -1476.

    Article  PubMed  CAS  Google Scholar 

  • Comroe, J. E., and Dripps, R. D., 1946, Histamine-like action of curare and tubocurarine injected intracutaneously and intraarterially in man, Anesthesiology 7: 260–262.

    Article  PubMed  CAS  Google Scholar 

  • Costanzi, J. J., and Coltman, J. R., 1967, Kappa chain cold precipitable immunoglobulin G (IgG) associated with cold urticaria. I. Clinical observations, Clin. Exp. Immunol 2: 167–178.

    PubMed  CAS  Google Scholar 

  • Crissey, J. T., Ferguson, J. L., and Bettenhausen, J. M., 1965, Cutaneous thermography with liquid crystals, J. Invest. Dermatol 45: 329–333.

    PubMed  CAS  Google Scholar 

  • Czarnetski, B M., König, W., and Lichtenstein, L. M., 1976a, Eosinophil chemotactic factor (ECF). I. Release from polymophonuclear leukocytes by the calcium ionophore A23187, J. Immunol 117:229–234.

    Google Scholar 

  • Czarnetski, B. M., König, W., and Lichtenstein, L. M., 1976b, Antigen-induced eosinophil chemotactic factor (ECF) release by human leukocytes, Inflammation 1: 201–215.

    Google Scholar 

  • Czarnetski, B. M., Kern, F., and Lichtenstein, L. M., 1976c, Defective release of eosinophil chemotactic factor from peripheral leukocytes in patients with chronic urticaria, J. Invest. Dermatol 67: 276–278.

    Article  Google Scholar 

  • Davis. P. J., Davis, F. B., and Charache, P., 1974, Longterm therapy of hereditary angioedema (HAE). Preventive management with fluoxymesterone and oxymethalone in severely affected males and females, Johns Hopkins Med. J 135: 391–398.

    PubMed  CAS  Google Scholar 

  • Day, N. K., Winfield, J. B., Gee, T., Winchester, R., Teshima, H., and Kunkel, H. G., 1976, Evidence for immune complexes involving anti-lymphocyte antibodies associated with hypocomplementaemia in chronic lymphocytic leukemia (CLL), Clin. Exp. Im-munol 26: 189–195.

    CAS  Google Scholar 

  • Demopoulos, C. A., Pinckard, R. N., and Hanahan, D. J., 1979, Platelet activating factor: Evidence for 1-o-alkyl2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators), J. Biol. Chem 254: 9355–9358.

    PubMed  CAS  Google Scholar 

  • Dixon, F. J., Vazquez, J. J., Weigle, W. O., and Cochrane, C. G., 1958, Pathogenesis of serum sickness, Arch. Pathol 65: 18–28.

    CAS  Google Scholar 

  • Dolovich, J., Hargreave, F. E., Chalmers, R., Shier, J., Gauldie, J., and Bienenstock, J., 1973, Late cutaneous allergic responses in isolated IgE-dependent reactions, J. Allergy Clin. Immunol 52: 38–46.

    Article  PubMed  CAS  Google Scholar 

  • Donaldson, V. H., and Evans, R. R., 1963, A biochemical abnormality in hereditary angioneurotic edema: Absence of serum inhibitor of C’1-esterase, Am. J. Med 35: 37–44.

    Article  PubMed  CAS  Google Scholar 

  • Donaldson, V. H., and Rosen, F. S., 1964, Action of complement in hereditary angioneurotic edema: Role of C’ 1-esterase, J. Clin. Invest 43: 2204–2213.

    Article  PubMed  CAS  Google Scholar 

  • Donaldson, V. H., Merler, E., and Rosen, F. S., 1978, Polypeptide kinin from hereditary angioneurotic edema plasma, in: Clinical Aspects of the Complement System, ( W. Opferkuch, K. Rother, and D. R. Schultz, eds.), pp. 130–133, Thieme, Stuttgart.

    Google Scholar 

  • Douglas, W. W., 1975, Histamine and antihistamines; 5 hydroxytraptamine and antagonists, in: The Pharmacologic Basis of Therapy ( L. S. Goodman and A. Gilman, eds.), pp. 590–629, Macmillan, New York.

    Google Scholar 

  • Dousa, T. P., and Code, C. F., 1974, Effect of histamine and its methyl derivatives on cyclic AMP metabolism in gastric mucosa and its blockage by an H2 receptor antagonist, J. Clin. Invest 53: 334–337.

    Article  PubMed  CAS  Google Scholar 

  • Drazen, J. M., and Austen, K. F., 1974, Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2 a on pulmonary mechanics in the guinea pig, J. Clin. Invest 53: 1679–1685.

    Article  PubMed  CAS  Google Scholar 

  • Drazen, J. M., Lewis, R. A., Wasserman, S. I., Orange, R. P., and Austen, K. F., 1979, Differential effects of a partially purified preparation of slow-reacting substance of anaphylaxis on guinea pig tracheal spirals and parenchymal strips, J. Clin. Invest 63: 1–5.

    Article  PubMed  CAS  Google Scholar 

  • Ellis, E., and Henney, C. S., 1969, Adverse reactions following administration of human gamma globulin, J. Allergy Clin. Immunol 43: 45–54.

    CAS  Google Scholar 

  • Engineer, D. M., Piper, P. J., and Sirois, P., 1976, Interaction between the release of SRS-A and of prostaglandins, Br. J. Pharmacol 57: 460P - 461 P.

    PubMed  CAS  Google Scholar 

  • Farr, R. S., 1970, The need to re-evaluate acetyl salicylic acid (aspirin), J. Allergy 45: 321–328.

    Article  PubMed  CAS  Google Scholar 

  • Frank, M. M., Sergent, J. S., Kane, M. A., and Ailing, D. W., 1972, Epsilon aminocaproic acid therapy of hereditary angioneurotic edema: A double-blind study, N. Engl. J. Med 286: 808–812.

    Article  PubMed  CAS  Google Scholar 

  • Frank, M. M., Gelfand, J. A., and Atkinson, J. P., 1976, Hereditary angioedema: The clinical syndrome and its management, Ann. Intern. Med 84: 580–593.

    PubMed  CAS  Google Scholar 

  • Gelfand, J. A., Sherine, R. J., Ailing, D. W., and Frank, M. M., 1976, Treatment of hereditary angioedema with danazol: Reversal of clinical and biochemical abnormalities, N. Engl. J. Med 295: 1444–1448.

    Article  PubMed  CAS  Google Scholar 

  • Gell, P. G. H., and Coombs, R. R. A., 1963, The classification of allergic reactions underlying disease, in: Clinical Aspects of Immunology ( P. G. H. Gell and R. R. A. Coombs, eds.), pp. 320–322, F. A. Davis, Philadelphia.

    Google Scholar 

  • Gleich, G. J., and Jacob, G. L., 1975, Immunoglobulin E antibodies to pollen allergens account for high percentages of total immunoglobulin E proteins, Science 190: 1106–1108.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, E. J., 1978, Regulation of the polymorphonuclear leukocyte chemotactic response by immunological reactions, in: Leukocyte Chemotaxis (J. I. Gallin and P. G. Quie, eds.), pp. 161–177, Raven Press, New York.

    Google Scholar 

  • Goetzl, E. J., and Austen, K. F., 1975, Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: Identification as eosinophil chemotactic factor of anaphylaxis, Proc. Natl. Acad. Sci. USA 72: 4123–4127.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, E. J., Ruddy, S., Stechschulte, D. J., and Austen, K. F., 1974, Immediate immunologic reactions: Noncytolytic mediator release and cytolytic cell destruction, in: Pharmacology and Pharmcokinetics ( T. Teorell, R. L. Dedrick, and P. G. Condliffe, eds), pp. 281–296, Plenum Press, New York.

    Google Scholar 

  • Granerus, G., Hallberg, L., Laurell, A.-B., and Wetterquist, H., 1967, Studies on the histamine metabolism and the complement system in hereditary angioneurotic edema, Acta Med. Scand 182: 11–22.

    Article  PubMed  CAS  Google Scholar 

  • Greaves, M. W., Yamamoto, S., and Fairley, V. M., 1972, IgE-mediated hypersensitivity in human skin studied using a new in vitro technique, Immunology 23: 239–248.

    PubMed  CAS  Google Scholar 

  • Greaves, W. M., Sneddon, I. B., Smith, A. K., and Stan-worth, D. R., 1974, Heat urticaria, Br. J. Dermatol 90: 289–292.

    Article  PubMed  CAS  Google Scholar 

  • Greaves, M., Marks, R., and Robertson, I., 1977, Receptors for histamine in human skin blood vessels: A review, Br. J. Dermatol 97: 225–228.

    Article  PubMed  CAS  Google Scholar 

  • Green, G. R., and Rosenblum, A., 1971, Report of the penicillin study group. American Academy of Allergy, J. Allergy Clin. Immunol 48: 331–343.

    Article  PubMed  CAS  Google Scholar 

  • Harber, L. C., Holloway, R. M., Wheatley, V. R., and Baer, R. L., 1963, Immunologic and biophysical studies in solar urticaria, J. Invest. Dermatol 41: 439–443.

    Article  PubMed  CAS  Google Scholar 

  • Hauptmann, G., Lang, J-M., North, M.-L., Oberling, F., Mayer, G., and Lachmann, P., 1976, Acquired CT-inhibitor deficiencies in lymphoproliferative diseases with serum immunoglobulin abnormalities: A study of three cases, Blut 32: 195–206.

    Article  PubMed  CAS  Google Scholar 

  • Hauptmann, G., Mayer, S., Lang, J.-M., Oberling, F., and Mayer, G., 1977, Treatment of acquired CT-inhibitor deficiency with danazol, Ann. Intern. Med 87: 577–578.

    PubMed  CAS  Google Scholar 

  • Hellgren, L., and Hersle, K., 1964, Acute and chronic urticaria. A statistical investigation on clinical and laboratory data in 1204 patients and matched healthy controls, Acta Allergol. 19: 406–420.

    PubMed  CAS  Google Scholar 

  • Henson, P. M., 1977, Activation of rabbit platelets by platelet-activating factor derived from IgE-sensitized basophils: Characteristics of the aggregation and its dissociation from secretion, J. Clin. Invest 60: 481–490.

    Article  PubMed  CAS  Google Scholar 

  • Hirsch, S. R., and Kalbfleisch, J. H., 1976, Circulating basophils in normal subjects and in subjects with hay fever, J. Allergy Clin. Immunol 58: 676–682.

    Article  PubMed  CAS  Google Scholar 

  • Illig, L., and Heinicke, A., 1967, Zur pathogenese der cholinergischen urticaria. IV. Zur frage einer echten antigen-antikörperreaktion, Arch. Klin. Exp. Dermatol 229: 360–371.

    PubMed  CAS  Google Scholar 

  • Ishizaka, K., Tomioka, H., and Ishizaka, T., 1970, Mech-anisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes, J. Immunol 105: 1459–1467.

    PubMed  CAS  Google Scholar 

  • Jager, B. V., 1967, Intravenous administration of modified gamma globulin: Several studies on a patient with agammaglobulinemia, Arch. Intern. Med 199: 60–64.

    Article  Google Scholar 

  • Jakschik, B. A., Falkenhein, S., and Parker, C. W., 1977, Precursor role of arachidonic acid in release of slow reacting substance from rat basophil leukemia cells, Proc. Natl. Acad. Sci. USA 74: 4577–4581.

    Article  PubMed  CAS  Google Scholar 

  • James, J., and Warin, R. P., 1971, An assessment of the role of Candida albicans and food yeasts in chronic urticaria, Br. J. Dermatol 84: 227–237.

    Article  PubMed  CAS  Google Scholar 

  • James, L. P., Jr., and Austen, K. F., 1964, Fatal systemic anaphylaxis in man, N. Engl. J. Med 270: 597–603.

    Article  PubMed  Google Scholar 

  • Kaliner, M., Orange, R. P., and Austen, K. F., 1972, Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. IV. Enhancement by cholinergic and a -adrenergic stimulation, J. Exp. Med 136: 556–557.

    Article  PubMed  CAS  Google Scholar 

  • Kaliner, M. A., Wasserman, S. I., and Austen, K. F., 1973, Immunologic release of chemical mediators from human nasal polyps, N. Engl. J. Med 289: 277–281.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, A. P., Gray, L., Shaff, R. E., Horakova, Z., and Beaven, M. A., 1975, In vivo studies of mediator release in cold urticaria and cholinergic urticaria, J. Allergy Clin. Immunol 55: 394–402.

    CAS  Google Scholar 

  • Kaplan, A. P., Hunt, K. J., Sobotka, A. K., Smith, P., Horakova, Z., Gralnick, H., and Lichtenstein, L. M., 1977, Human anaphylaxis: A study of mediator systems, Clin. Res 25: 361A.

    Google Scholar 

  • Kay, A. B., and Austen, K. F., 1971, The IgE-mediated release of an eosinophil leukocyte chemotactic factor from human lung, J. Immunol 107: 899–902.

    PubMed  CAS  Google Scholar 

  • Kay, A. B., Stechschulte, D. J., and Austen, K. F., 1971, An eosinophil leukocyte chemotactic factor of anaphylaxis, J. Exp. Med 133: 602–619.

    Article  PubMed  CAS  Google Scholar 

  • Kern, F., and Lichtenstein, L. M., 1976, Defective histamine release in chronic urticaria, J. Clin. Invest 57: 1369–1377.

    Article  PubMed  CAS  Google Scholar 

  • Kiernan, J. A., 1976, Evidence for the involvement of vasoactive constitutents of mast cells in axon reflex vasodilation in the skin of the rat, Arch. Dermatol. Res 255: 1–8.

    Article  CAS  Google Scholar 

  • Kirby, J. D., Matthews, C. N. A., James, J., Duncan, E. H. L., and Warin, R. P., 1971, The incidence and other aspects of factitious wealing (dermographism), Br. J. Dermatol 85: 331–335.

    Article  PubMed  CAS  Google Scholar 

  • Kravis, T. C., and Henson, P. M., 1977, Accumulation of platelets at sites of antigen-antibody-mediated injury: A possible role for IgE antibody and mast cells, J. Immunol 118: 1569–1573.

    PubMed  CAS  Google Scholar 

  • Lagunoff, D., 1972, Contributions of electron microscopy to the study of mast cells, J. Invest. Dermatol 58: 296–311.

    Article  PubMed  CAS  Google Scholar 

  • Lagunoff, D., and Benditt, E. P., 1963, Proteolytic enzymes of mast cells, Ann. N.Y. Acad. Sci 103: 185–198.

    Article  PubMed  CAS  Google Scholar 

  • Lagunoff, D., Pritzl, P., and Mueller, L., 1970, N-Acetyl-ß-glucosaminidase in rat mast cell granules, Exp. Cell. Res 61: 129–132.

    Article  PubMed  CAS  Google Scholar 

  • Lasser, E. G., 1968, Basic mechanism of contrast media reactions, Radiology 91: 63–73.

    PubMed  CAS  Google Scholar 

  • Laurell, A.-B., Martensson, U., and Sjöholm, A. G., 1977, Studies of CI subcomponents in chronic urticaria and angioedema, Int. Arch. Allergy Appl. Immunol 54: 434–442.

    Article  PubMed  CAS  Google Scholar 

  • Leikola, J., Koistinen, J., Lehtinen, M., and Virolainen, M., 1973, IgA-induced anaphylactic transfusion reactions. A report of four cases, Blood 42: 111–119.

    PubMed  CAS  Google Scholar 

  • Lepow, I. H., Willms-Kretschmer, K., Patrick, R. A., and Rosen, F. S., 1970, Gross and ultrastructural observations on lesions produced by intradermal injection of human C3a in man, Am. J. Pathol 61: 13–24.

    PubMed  CAS  Google Scholar 

  • Lever, W. F., and Schaumburg-Lever, G., 1975, Histopathology of the Skin, p. 133, Lippincott, Philadelphia.

    Google Scholar 

  • Lewis, R. A., Goetz!, E. J., Wasserman, S. I., Valone, F. H., Rubin, R. H., and Austen, K. F., 1975, The release of four mediators of immediate hypersensitivity from human leukemic eosinophils, J. Immunol 114: 87–92.

    PubMed  CAS  Google Scholar 

  • Lewis, R. A., Roberts,.L. J., II, Holgate, S. T., Oates, J. A., and Austen, K. F., 1980a, Prostaglandin D2 production by rat and human mast cells activated by reversed anaphylaxis, Fed. Proc 39: 905.

    Google Scholar 

  • Lewis, R. A., Austen, K. F., Drazen, J. M., Clark, D. A., and Corey, E. J., 19806, Slow reacting substance of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources, Proc. Natl. Acad. Sci. USA (in press).

    Google Scholar 

  • Lewis„ T., 1927, The Blood Vessels of the Human Skin and Their Responses, Shaw, London.

    Google Scholar 

  • Lichtenstein, L. M., and Gillespie, E., 1975, The effects of H1 and H2 antihistamines on “allergic” histamine release and its inhibition by histamine, J. Pharmacol. Exp. Ther 192: 441–450.

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L. M., and Oster, A. G., 1964, Studies on the mechanisms of hypersensitivity phenomena. IX. Histamine release from human leukocytes by ragweed pollen antigen, J. Exp. Med 120: 507–530.

    Article  PubMed  CAS  Google Scholar 

  • Lichtenstein, L. M., Valentine, M. D., and Sobotka, A. K., 1974, A case for venom treatment in anaphylactic sensitivity to hymenoptera sting, N. Engl. J. Med 290: 1223–1227.

    Article  PubMed  CAS  Google Scholar 

  • Lundh, B., Laurell, A. B., Wetterquist, H., White, T., and Granerus, G., 1968, A case of hereditary angioneurotic oedema, successfully treated with e-aminocaproic acid. Studies on C’ 1 esterase inhibitor, C’ 1 activation, plasminogen level, and histamine metabolism, Clin. Exp. Immunol 3: 733–745.

    PubMed  CAS  Google Scholar 

  • Lynch, S. M., Austen, K. F., and Wasserman, S. I., 1978, Release of arylsulfatase A but not B from rat mast cells by non-cytolytic secretory stimuli, J. Immunol 121: 1394–1399.

    PubMed  CAS  Google Scholar 

  • Majno, G., and Palade, G. E., 1961, Studies on inflammation. I. The effect of histamine and serotonin on vascular permeability, J. Biophys. Biochem. Cytol 11: 571–605.

    Article  PubMed  CAS  Google Scholar 

  • Marsh, D. G., 1976, Allergy: A model for studying the genetics of human immune response, in: Molecular and Biological Aspects of the Acute Allergic Reaction ( S. G. O. Johansson, K. S. Strandberg, and B. Uvnäs, eds.), pp. 23–57, Plenum Press, New York.

    Chapter  Google Scholar 

  • Marsh, D. G., Bias, W. B., and Ishizaka, K., 1974, Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic specificity, Proc. Natl. Acad. Sci. USA 71: 3588–3592.

    CAS  Google Scholar 

  • Mathews, K. P., Hemphill, F. M., Lovell, R. G., Forsythe, W. E., and Sheldon, J. M., 1956, Controlled study on use of parenteral and oral antihistamines in preventing penicillin reactions, J. Allergy 27: 1–15.

    Article  PubMed  CAS  Google Scholar 

  • Mathison, D. A., Arroyave, C. M., Bhat, K. N., Hurewitz, D. S., and Marnell, D. J., 1977, Hypocomplementemia in chronic idiopathic urticaria, Ann. Intern. Med 86: 534–538.

    PubMed  CAS  Google Scholar 

  • McManus, L. M., Morley, C. A., Levine, S. P., and Pinckard, R. H., 1979, Platelet activating factor (PAF) induced release of platelet factor 4 (PF4) in vitro and during IgE anaphylaxis in the rabbit, J. Immunol 123: 2835–2841.

    PubMed  CAS  Google Scholar 

  • McNeill, J. H., and Verma, S. C., 1974, Blockade by burimamide of the effects of histamine and histamine analogues on cardiac contractility, phosphorylase activation, and cyclic adenosine monophosphate, J. Pharmacol. Exp. Ther 188: 180–188.

    PubMed  CAS  Google Scholar 

  • Metcalfe, D. D., Lewis, R. A., Silbert, J. E., Rosenberg, R. D., Wasserman, S. I., and Austen, K. F., 1979, Isolation, and characterization of heparin from human lung, J. Clin. Invest 64: 1537–1543.

    Article  PubMed  CAS  Google Scholar 

  • Metcalfe, D. D., Wasserman, S. I., and Austen, K. F., 1980, Isolation and characterization of sulfated muco-polysaccharides from rat leukaemic (RBL-1) basophils, Biochem. J 185: 367–372.

    PubMed  CAS  Google Scholar 

  • Michaëlsson, G., and Juhlin, L., 1973, Urticaria induced by preservatives and dye additives in food and drugs, Br. J. Dermatol 88: 525–532.

    Article  PubMed  Google Scholar 

  • Mikhail, G. R., and Miller-Milinska, A., 1964, Mast cell population in human skin, J. Invest. Dermatol 43: 249–254.

    PubMed  CAS  Google Scholar 

  • Moore-Robinson, M., and Warin, R. P., 1967, Effect of salicylates in urticaria, Br. Med. J 4: 262–265.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, R. C., Hammarström, S., and Samuelsson, B., 1979, Leukotriene C: A slow-reacting substance from murine mastocytoma cells, Proc. Natl. Acad. Sci. USA 76: 4275–4279.

    Article  PubMed  CAS  Google Scholar 

  • Newball, H. H., Berninger, R. W., Talamo, R. C., and Lichtenstein, L. M., 1979a, Anaphylactic release of a basophil kallikrein-like activity. I. Purification and characterization, J. Clin. Invest 64: 457–465.

    Article  PubMed  CAS  Google Scholar 

  • Newball, H. H., Talamo, R. C., and Lichtenstein, L. M., 19756, Release of leukocyte kallikrein mediated by IgE, Nature (London) 254: 635–636.

    Google Scholar 

  • Newball, H. H., Berninger, R. W., Talamo, R. C., and Lichenstein, L. M., 1979a, Anaphylactic release of a basophil kallikrein-like activity. I. Purification and characterization, J. Clin. Invest 64: 457–465.

    Article  PubMed  CAS  Google Scholar 

  • Newball, H. H., Talamo, R. C., and Lichenstein, L. M., 19796, Anaphylactic release of a basophil kallikrein-like activity. II. A mediator of immediate hypersensitivity reactions, J. Clin. Invest 64: 466–475.

    Google Scholar 

  • Newcomb, R. W., and Nelson, H., 1973, Dermographia mediated by immunoglobulin E, Am. J. Med 54: 174–180.

    Article  PubMed  CAS  Google Scholar 

  • Oishi, M., Takano, M., Miyachi, K., Ichikawa, Y., and Homma, M., 1976, A case of unusual SLE related syndrome characterized by erythema multiforme, angioneurotic edema, marked hypocomplementemia, and Clq precipitins of the low molecular weight type, Int. Arch. Allergy Appl. Immunol 50: 463–472.

    Article  PubMed  CAS  Google Scholar 

  • Orange, R. P., and Austen, K. F., 1969, Slow reacting substance of anaphylaxis, Adv. Immunol 10: 105–144.

    Article  PubMed  CAS  Google Scholar 

  • Orange, R. P., and Moore, E. G., 1976, Functional characterization of rat mast cell arylsulfatase activity, J. Immunol 117: 2191–2196.

    PubMed  CAS  Google Scholar 

  • Orange, R. P., Austen, W. G., and Austen, K. F., 1971, Immunological release of histamine and slow-reacting substance of anaphylaxis from human lung. I. Modulation by agents influencing cellular levels of cyclic 3’,5’-adenosine monophosphate, J. Exp. Med 134: 136s - 148s.

    PubMed  CAS  Google Scholar 

  • Orange, R. P., Murphy, R. C., Karnovsky, M. L., and Austen, K. F., 1973, The physicochemical characteristics and purification of slow reacting substance of anaphylaxis, J. Immunol 110: 760–770.

    PubMed  CAS  Google Scholar 

  • Orange, R. P., Murphy, R. C., and Austen, K. F., 1974, Inactivation of slow reacting substance of anaphylaxis (SRS-A) by arylsulfatases, J. Immunol 113: 316–322.

    PubMed  CAS  Google Scholar 

  • Orenstein, N. S., Galli, S. J., Hammond, M. E., Smith, G. N., Silbert, J. E., and Dvorak, H. F., 1978, Sulfated glycosaminoglycans of guinea pig basophilic leukocytes, J. Immunol 121: 586–592.

    PubMed  CAS  Google Scholar 

  • Osier, W., 1888, Hereditary angio-neurotic oedema, Am. J. Med. Sci 95: 362–367.

    Article  Google Scholar 

  • Palmer, M. A., Piper, P. J., and Vane, J. R., 1973, Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br. J. Pharmacol 49: 226–242.

    Article  PubMed  CAS  Google Scholar 

  • Parker, C. W., 1975, Drug allergy, N. Engl. J. Med. 292:511–514, 732–736, 937–960.

    Google Scholar 

  • Patterson, R., Mellies, C. J., Blankenship, M. L., and Pruzansky, J. J., 1972, Vibratory angioedema: A hereditary type of physical hypersensitivity, J. Allergy Clin. Immunol 50: 174–182.

    Article  PubMed  CAS  Google Scholar 

  • Pearce, C. A., Greaves, M. W., Plummer, V. M., and Yamamoto, S., 1974, Effect of disodium cromoglycate on antigen-evoked histamine release from human skin, Clin. Exp. Immunol 17: 437–440.

    PubMed  CAS  Google Scholar 

  • Pence, H. L., Evans, R., Guernsey, L. H., and Gerhard, R. C., 1974, Prophylactic use of epsilon aminocaproic acid for oral surgery in a patient with hereditary angioneurotic edema, J. Allergy Clin. Immunol 53: 298–302.

    Article  PubMed  CAS  Google Scholar 

  • Pinckard, R. H., Farr, R. S., and Hanahan, D. J., 1979, Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils, J. Immunol 123: 1847–1857.

    PubMed  CAS  Google Scholar 

  • Plant, M., Lichtenstein, L. M., and Henney, C. S., 1975, Properties of a subpopulation of T cells bearing histamine receptors, J. Clin. Invest 55: 856–874.

    Article  Google Scholar 

  • Roberts, L. J., II, Lewis, R. A., Oates, J. A., and Austen, K. F., 1979, Prostaglandin, thromboxane, and 12 hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells, Biochem. Biophys. Acta 575: 185–192.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, L. J., II, Sweetman, B. J., Lewis, R. A., Folarin, V. F., Austen, K. F., and Oates, J. A., 1980, Markedly increased synthesis of prostaglandin D2 in mastocytosis, Clin. Res 28: 552A.

    Google Scholar 

  • Ros, A. M., Juhlin, L., and Michaëlsson, G., 1976, A follow-up study of patients with recurrent urticaria and hypersensitivity to aspirin, benzoates, and azo dyes, Br. J. Dermatol 05: 19–24.

    Article  Google Scholar 

  • Rose, B., 1941, Studies on blood histamine in cases of allergy. I. Blood histamine during wheal formation, J. Allergy 12: 327–334.

    Article  CAS  Google Scholar 

  • Rosen, F. S., Charache, P., Pensky, J., and Donaldson, V., 1965, Hereditary angioneurotic edema: Two genetic variants, Science 148: 957–958.

    Article  PubMed  CAS  Google Scholar 

  • Rosenfeld, S. I., Staples, P. J., and Leddy, J. P, 1975, Angioedema and hypocomplementemia: Unusual feature of lymphoma, J. Allergy Clin. Immunol 55: 104

    Google Scholar 

  • Rosse, W. F., Logue, G. L., Silberman, H. R., and Frank, M. M., 1976, The effect of synthetic androgens in hereditary angioneurotic edema: Alteration of Cl inhibitor and C4 levels, Tr. Assoc. Am. Physicians 89: 122–132.

    CAS  Google Scholar 

  • Ruddy, S., and Austen, K. F., 1967, A stoichiometric assay for the fourth component of complement in whole human serum using EAC’ la HP and functionally pure human second component, J. Immunol 99: 1162–1172.

    PubMed  CAS  Google Scholar 

  • Ruddy, S., Carpenter, C. B., Müller-Eberhard, H. J., and Austen, K. F., 1968, Complement component levels in hereditary angioneurotic edema and isolated C’2 deficiency in man, in: Mechanisms of Inflammation Induced by Immune Reactions. Fifth Immúnopathology International Symposium ( P. A. Miescher and P. Grabar, eds.), pp. 231–251, Schwabe, Basel.

    Google Scholar 

  • Ruddy, S., Carpenter, C. B., Chin, K. W., Knostman, J. N., Soter, N. A., Götze, O., Müller-Eberhard, H. J., and Austen, K. F., 1975, Human complement metabolism: An analysis of 144 studies, Medicine 54: 165–178.

    Google Scholar 

  • Rudzki, E., Borkowski, W., and Czubalski, K., 1970, The suggestive effect of placebo on the intensity of chronic urticaria, Ann. Allergy 25: 70–73.

    CAS  Google Scholar 

  • Ryan, T. J., Shim-Young, N., and Turk, J. L., 1968, Delayed pressure urticaria, Br. J. Dermatol 80: 485–490.

    Article  PubMed  CAS  Google Scholar 

  • Sams, W. M., Jr., Epstein, J. H., and Winkelmann, R. K., 1969, Solar urticaria: Investigation of pathogenetic mechanisms, Arch. Dermatol 99: 390–397.

    Article  PubMed  Google Scholar 

  • Samter, M., and Beers, R. J., Jr., 1967, Concerning the nature of intolerance to aspirin, J. Allergy 40: 281–293.

    Article  PubMed  CAS  Google Scholar 

  • Schatz, M., Patterson, R., O’Rourke, J., Nickelson, J., and Northrup, C., 1975, The administration of radiographic contrast media to patients with a history of previous reaction, J. Allergy Clin. Immunol 55: 358–366.

    Article  PubMed  CAS  Google Scholar 

  • Schayer, R. W., 1965, Histamine and circulatory homeostasis, Fed. Proc 24: 1295–1297.

    PubMed  CAS  Google Scholar 

  • Schmidt, A. P., Taswell, H. F., and Gleich, G. J., 1969, Anaphylactic transfusion reactions associated with anti-IgA antibody, N. Engl. J. Med 280: 188–193.

    Article  PubMed  CAS  Google Scholar 

  • Schoenfeld, M. R., 1960, Acute allergic reactions to morphine, codeine, meperidine hydrochoride, and opium alkaloids, N.Y. J. Med 60: 2591–2593.

    CAS  Google Scholar 

  • Schreiber, A. D., Zweiman, B., Atkins, P., Goldwein, F., Pietra, G., Atkinson, B., and Abdou, N. I., 1976, Acquired angioedema with lymphoproliferative disorder: Association of Cl inhibitor deficiency with cellular abnormality, Blood 48: 567–580.

    PubMed  CAS  Google Scholar 

  • Schwartz, L. B., and Austen, K. F., 1980, Enzymes of the mast cell granule, J. Invest. Dermatol 74: 349–353.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, L. B., Austen, K. F., and Wasserman, S. I., 1979, Immunologic release of ß-hexosaminidase and ßglucuronidase from purified rat serosal mast cells, J. Immunol 123: 1445–1450.

    PubMed  CAS  Google Scholar 

  • Schwartz, L. B., Lewis, R. A., and Austen, K. F., 1980, Immunologic release of hexosaminidase (Hex), glucuronidase (Gu), arylsulfatase (As), and tryptase activity from dispersed human pulmonary mast cells, Clin. Res 28: 559A.

    Google Scholar 

  • Settipane, G. A., and Pudupakkam, R. K., 1975, Aspirin intolerance. III. Subtypes, familial occurrence, and cross-reactivity with tartrazine, J. Allergy Clin. Immunol 56: 215–221.

    Article  PubMed  CAS  Google Scholar 

  • Sheard, P., and Blair, A. M. J. N., 1970, Disodium cromoglycate: Activity in three in vitro models of the immediate hypersensitivity reaction in lung, Int. Arch. Allergy Appl. Immunol 38: 217–224.

    Article  PubMed  CAS  Google Scholar 

  • Sheffer, A. L., and Austen, K. F., 1980, Exercise-induced anaphylaxis, J. Allergy Clin. Immunol (in press).

    Google Scholar 

  • Sheffer, A. L., Craig, J. M., Willms-Kretschmer, K., Austen, K. F., and Rosen, F. S., 1971, Histopathological and ultrastructural observations on tissues from patients with hereditary angioneurotic edema, J. Allergy 47: 292–297.

    PubMed  CAS  Google Scholar 

  • Sheffer, A. L., Austen, K. F., and Rosen, F. S., 1972, Tranexamic acid therapy in hereditary angioneurotic edema, N. Engl. J. Med 287: 452–454.

    Article  PubMed  CAS  Google Scholar 

  • Sheffer, A. L., Fearon, D. T., Austen, K. F., and Rosen, F. S., 1977a, Tranexamic acid: Preoperative prophylactic therapy for patients with hereditary angioneurotic edema (HAE), J. Allergy Clin. Immunol 60: 38–40.

    Article  PubMed  CAS  Google Scholar 

  • Sheffer, A. L., Fearon, D. T., and Austen, K. F., 1977b, Methyltestosterone therapy in hereditary angioedema, Ann. Intern. Med 86: 306–308.

    PubMed  CAS  Google Scholar 

  • Sheffer, A. L., Fearon, D. T., and Austen, K. F., 1979, Clinical and biochemical effects of impeded androgen (oxymetholone) therapy of hereditary angioedema, J. Allergy Clin. Immunol 64: 275–280.

    Article  PubMed  CAS  Google Scholar 

  • Sherman, W. B., and Seebohm, P. M., 1950, Passive transfer of cold urticaria, J. Allergy 21: 414–424.

    Article  PubMed  CAS  Google Scholar 

  • Sobotka, A. K., Adkinson, N. F., Jr., Valentine, M. D., and Lichtenstein, L. M., 1978, Allergy to insect stings. IV. Diagnosis by radioallergosorbent test (RAST) J. Immunol. 121: 2477–2484.

    PubMed  CAS  Google Scholar 

  • Solley, G. O., Gleich, G. J., Jordon, R. E., and Schroeter, A. L., 1976, The late phase of the immediate wheal and flare skin reactions. Its dependence upon IgE antibodies, J. Clin. Invest 58: 408–420.

    Article  PubMed  CAS  Google Scholar 

  • Soter, N. A., 1977, Chronic urticaria as a manifestation of necrotizing venulitis, N. Engl. J. Med 296: 1440–1442.

    Article  PubMed  CAS  Google Scholar 

  • Soter, N. A., Mihm, M. C., Jr., Gigli, I., Dvorak, H. F., and Austen, K. F., 1976a, Two distinct cellular patterns in cutaneous necrotizing angiitis, J. Invest. Dermatol 66: 344–350.

    Article  PubMed  CAS  Google Scholar 

  • Soter, N. A., Wasserman, S. I., and Austen, K. F., 1976b, Cold urticaria: Release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge, N. Engl. J. Med 294: 687–690.

    Article  PubMed  CAS  Google Scholar 

  • Soter, N. A., Joshi, N. P., Twarog, F. J., Zeiger, R. S., Rothman, P., and Cotten, H. R., 1977, Delayed cold-induced urticaria: A dominantly inherited disorder, J. Allergy Clin. Immunol 59: 294–297.

    Article  PubMed  CAS  Google Scholar 

  • Soter, N. A., Mihm, M. C., Jr., Dvorak, H. F., and Austen, K. F., 1978, Cutaneous necrotizing venulitis: A sequential analysis of the morphologic alterations occurring after mast cell degranulation in a patient with a unique syndrome, Clin. Exp. Immunol 32: 46–58.

    PubMed  CAS  Google Scholar 

  • Soter, N. A., Wasserman, S. I., Pathak, M. A., Parrish, J. A., and Austen, K. F., 1979, Solar urticaria: Release of mast cell mediators into the circulation after experimental challenge, J. Invest. Dermatol 72: 282.

    Google Scholar 

  • Soter, N. A., Wasserman, S. I., Austen, K. F., and McFadden, E. R., Jr., 1980, Mast cell mediator release and alteration in lung function in individuals with cholinergic urticaria, N. Engl. J. Med 302: 604–608.

    Article  PubMed  CAS  Google Scholar 

  • Spark, R. P., 1971, Fatal anaphylaxis due to oral penicillin, Clin. Pathol 56: 407–411.

    CAS  Google Scholar 

  • Spaulding, W. B., 1960, Methyltestosterone therapy for hereditary episodic edema (hereditary angioneurotic edema), Ann. Intern. Med 53: 739–745.

    Google Scholar 

  • Stevenson, D. D., Arroyave, C. M., Bhat, K. N., and Tan, E. M., 1976, Oral aspirin challenges in asthmatic patients: A study of plasma histamine, Clin. Allergy 6: 493–505.

    Article  PubMed  CAS  Google Scholar 

  • Szczeklik, A., Gryglewski, R. J., Czerniawska-Mysik, G., and Zmuda, A., 1976, Aspirin-induced asthma: Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations, J. Allergy Clin. Immunol 58: 10–18.

    Article  PubMed  CAS  Google Scholar 

  • Takatsu, K., Ishizaka, K., and King, T. P., 1975, Immunologic properties of modified antigen E. III. Effect of repeated injections of modified antigen on immunocompetent cells specific for native antigen, J. Immunol 115: 1469–1476.

    CAS  Google Scholar 

  • Tauber, A. I., Kaliner, M., Stechschulte, D. J., and Austen, K. F., 1973, Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine, J. Immunol 111: 27–32.

    PubMed  CAS  Google Scholar 

  • Tindall, J. P., Beeker, S. K., and Rosse, W. F., 1969, Familial cold urticaria: A generalized reaction involving leukocytosis, Arch. Intern. Med 124: 129–134.

    Article  PubMed  CAS  Google Scholar 

  • Trotter, C. M., and Orr, T. S. C., 1974, A fine structure study of some cellular components in allergic reactions. H. Mast cells in normal and atopic human skin, Clin. Allergy 4: 421–433.

    Article  Google Scholar 

  • Turnbull, L. W., Evans, D. P., and Kay, A. B., 1977, Human eosinophils, acidic tetrapeptides (ECF-A), and histamine: Interactions in vitro and in vivo, Immunology 32: 57–63.

    PubMed  CAS  Google Scholar 

  • Vallota, E. H., and Miiller-Eberhard, H. J., 1973, Formation of C3a and C5a anaphylatoxins in whole human serum after inhibition of the anaphylatoxin inactivator, J. Exp. Med 137: 1109–1122.

    Article  PubMed  CAS  Google Scholar 

  • Van Arsdel, P. P., 1968, The risk of penicillin reactions, Ann. Intern Med 69: 10711–073.

    Google Scholar 

  • Vyas, G. N., and Fudenberg, H. H., 1969, Iso-immune anti-IgA causing anaphylactoid transfusion reactions, N. Engl. J. Med 280: 1073–1074.

    Article  PubMed  CAS  Google Scholar 

  • Vyas, G. N., Holmdahl, L., Perkins, H. A., and Fudenberg, H. H., 1969, Serologic specificity of human antiIgA and its significance in transfusion, Blood 34: 573–581.

    PubMed  CAS  Google Scholar 

  • Wasserman, S. I., and Austen, K. F., 1976, Arylsulfatase B of human lung: Isolation, characterization, and interaction with slow reacting substance of anaphylaxis, J. Clin. Invest 57: 738–744.

    Article  PubMed  CAS  Google Scholar 

  • Wasserman, S. I., Goetzl, E. J., and Austen, K. F., 1975, Inactivation of slow reacting substance of anaphylaxis by human eosinophil arylsulfatase, J. Immunol 114: 645–649.

    PubMed  CAS  Google Scholar 

  • Wasserman, S. I., Soter, N. A., Center, D. M., and Austen, K. F., 1977, Cold urticaria: Recognition and characterization of a neutrophil chemotactic factor which appears in serum during experimental cold challenge, J. Clin. Invest 60: 189–196.

    Article  PubMed  CAS  Google Scholar 

  • Wasserman, S. I., Sheffer, A. L., Soter, N. A., Austen, K. F., and McFadden, E. R., 1978, Assessment of mast cell mediators and pulmonary function in aspirin (ASA)-induced bronchospasm, J. Allergy Clin. Immunol 61: 139.

    Article  Google Scholar 

  • Wasserman, S. I., Soter, N. A., Poser, J., and Austen, K. F., 1980, Eosinophil chemotactic factors in human disease: Evidence of heterogeneity, Clin. Res 28: 254A.

    Google Scholar 

  • Webster, M. E., Horakova, Z., Beaven, M. A., Takahashi, H., and Newball, H. H., 1974, Release of arginine esterase and histamine from human lung previously sensitized with ragweed antibody, Fed. Proc 33: 761.

    Google Scholar 

  • Weigle, W. O., and Dixon, F. J., 1958, Relationship of circulating antigen-antibody complexes, antigen elimination and complement in serum sickness, Proc. Soc. Exp. Biol. Med 99: 226–231.

    PubMed  CAS  Google Scholar 

  • Weiss, S., Robb, C. P., and Ellis, L. B., 1932, The systemic effects of histamine in man: With special refer-ence to the responses of the cardiovascular system, Arch. Intern. Med 49: 360–396.

    Article  Google Scholar 

  • Wells, J. V., Buckley, R. H., Schonfield, M. S., and Fudenberg, H. H., 1977, Anaphylactic reactions to plasma infusions in patients with hypogammaglobulinemia and anti-IgA antibodies, Clin. Immunol. Immunopathol 8: 265–271.

    Article  PubMed  CAS  Google Scholar 

  • Whitten, D. M., 1975, Reaction to urographic contrast media, J. Am. Med. Assoc 231: 974–977.

    Article  Google Scholar 

  • Wuepper, K. D., Bokisch, V. A., Müller-Eberhard, J. H., and Stoughton, R. B., 1972, Cutaneous responses to human C3 anaphylatoxin in man, Clin. Exp. Immunol 11: 13–20.

    PubMed  CAS  Google Scholar 

  • Yurchak, A. M., Wicher, K., and Arbesman, C. E., 1970, Immunologic studies on aspirin, J. Allergy 46: 245–253.

    Article  PubMed  CAS  Google Scholar 

  • Yurt, R. W., and Austen, K. F., 1977, Preparative purification of the rat mast cell chymase: Characterization and interaction with granule components, J. Exp. Med 146: 1405–1419.

    Article  PubMed  CAS  Google Scholar 

  • Yurt, R. W., Leid, R. W., Austen, K. F., and Silbert, J. E., 1977, Native heparin from rat peritoneal mast cells, J. Biol. Chem 252: 518–521.

    PubMed  CAS  Google Scholar 

  • Zweiman, B., and Hildreth, E. A., 1974, An approach to contrast studies in reactive humans, J. Allergy Clin. Immunol 53: 97.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Dermatology and Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Nicholas A. Soter & K. Frank Austen

  2. the Divisions of Dermatology, Boston, Massachusetts, 02115, USA

    Nicholas A. Soter & K. Frank Austen

  3. Departments of Medicine, Robert B. Brigham and Peter, Bent Brigham Divisions of the Affiliated Hospitals Center, Boston, Massachusetts, 02115, USA

    Nicholas A. Soter & K. Frank Austen

Authors
  1. Nicholas A. Soter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Frank Austen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Publishing Corporation

About this chapter

Cite this chapter

Soter, N.A., Austen, K.F. (1981). Urticaria/Angioedema. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7228-2_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7230-5

  • Online ISBN: 978-1-4615-7228-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation