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Allergic Contact Dermatitis, Photoallergic Contact Dermatitis, and Phototoxic Dermatitis

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Immunodermatology

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

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Abstract

Allergic eczematous contact dermatitis (ACD) is a disease of great clinical, scientific, and historical interest. This is in part due to the very characteristic changes in the epidermis and dermis evoked by this perhaps most uniquely “cutaneous” immunological response. Its historical interest derives from the fact that some of the first recognized cardinal clinical features of immune responses in man can be traced to ACD. These include the clear-cut relationship between clinical exposure to the allergen and the resultant predictable clinical and histological changes, the reproduction of the disease by deliberate exposure to the allergen, and the development of the patch test as a clinically useful tool.

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References

  • Allison, A. C., Magnus, I. A., and Young, M. R., 1966, Role of lysosomes and of cell membranes in photosensitization, Nature 209: 874–879.

    Article  PubMed  CAS  Google Scholar 

  • Baer, R. L., 1964, Allergic eczematous sensitization in man, 1936 and 1964, J. Invest. Dermatol. 43: 223–229.

    PubMed  CAS  Google Scholar 

  • Baer, R. L., and Rosenthal, S. A., 1972, Induction of cross-tolerance for contact sensitivity by a non-immunogenic chemical. Feeding dichloronitrobenzene induced tolerance to dinitrochlorobenzene. J. Immunol. 108: 706–710.

    PubMed  CAS  Google Scholar 

  • Baer, R. L., and Sulzberger, M. D., 1952, Attempts at passive transfer of allergic eczematous sensitivity in man, J. Invest. Dermatol. 18: 53–59.

    Article  PubMed  CAS  Google Scholar 

  • Baer, R. L., Rosenthal, S. A., and Sims, C. F., 1957, The allergic eczema-like reaction and the primary irritant reaction: A histologic comparison of their evolution in the acanthotic skin of guinea pigs, Arch. Dermatol. 76: 549–560.

    Article  CAS  Google Scholar 

  • Brandriss, M. W., 1968, Attempt to transfer contact hypersensitivity in man with dialysates of peripheral leucocytes, J. Clin. Invest. 47: 2152–2157.

    Article  PubMed  CAS  Google Scholar 

  • Burry, J. M. 1967, Photoallergies to Fentichlor and Multifungin, Arch. Dermatol. 95: 287–291.

    Article  PubMed  CAS  Google Scholar 

  • Chase, M. W., 1945, The cellular transfer of cutaneous hypersensitivity to tuberculin, Proc. Soc. Exp. Biol. Med. 59: 134–135.

    Google Scholar 

  • Christensen, O. B., and Moller, H., 1975, External and internal exposure to the antigen in the hand eczema of nickel allergy, Contact Dermatitis 1: 136–141.

    Article  PubMed  CAS  Google Scholar 

  • Cole, R. S., 1970, Light-induced cross linking of DNA in the presence of a furocoumarin (psoralen), Biochim. Biophys. Acta 217: 30–39.

    Article  PubMed  CAS  Google Scholar 

  • Cormane, R. H., Husz, S., and Hamerlinck, F., 1974, Immunoglobulin-and complement-bearing lymphocytes in allergic contact dermatitis and atopic dermatitis (eczema), Br. J. Dermatol. 90: 597–6604.

    Article  PubMed  CAS  Google Scholar 

  • Coxon, J. A., Jenkins, F. P., and Welti, D., 1965, The effect of light on halogenated salicylanilide ions, Photochem. Photobiol. 4: 713–718.

    Article  CAS  Google Scholar 

  • DeHurtado, 1., and Osier, A. G., 1975, Serum antibody production—An invariable consequence of sensitization with DNCB, Proc. Soc. Exp. Biol. Med. 149: 628–632.

    PubMed  Google Scholar 

  • Dvorak, H. F., Dvorak, A. M., Simpson, B. A., Richer-son, H. B., Leskowitz, S., and Karnovsky, M. J., 1970, Cutaneous basophil hypersensitivity. II. A light and electron microscopic description, J. Exp. Med. 132: 558–582.

    Article  PubMed  CAS  Google Scholar 

  • Dvorak, H. F., Simpson, B. A., Bast, R. C., Jr., and Leskowitz, S., 1971, Cutaneous basophile hypersensitivity. III. Participation of the basophil in hypersensitivity to antigen-antibody complexes, delayed hypersensitivity and contact allergy. Passive transfer, J. Immunol. 107: 138–148.

    PubMed  CAS  Google Scholar 

  • Dvorak, H. F., Mihm, C. M., Jr., and Dvorak, A. M., 1976, Morphology of delayed-type hypersensitivity reactions in man, J. Invest. Dermatol. 67: 391–401.

    Article  PubMed  CAS  Google Scholar 

  • Eisen, H. N., Orris, L., and Belman, S., 1952, Elicitation of delayed allergic skin reactions with haptens, J. Exp. Med. 95: 473–487.

    Article  PubMed  CAS  Google Scholar 

  • Epstein, S., 1939, Photoallergy and primary photosensi- tivity to sulfanilamide, J. Invest. Dermatol. 2: 43–51.

    Article  CAS  Google Scholar 

  • Epstein, S., 1960, Allergic photo-contact dermatitis from promethazine (Phenergan), Arch. Dermatol. 81: 175–180.

    Article  PubMed  CAS  Google Scholar 

  • Epstein, S., 1966, Simplified photopatch testing, Arch. Dermatol. 93: 216–220.

    Article  PubMed  CAS  Google Scholar 

  • Epstein, W. L., and Kligman, A. M., 1957, Transfer of allergic contact-type delayed sensitivity in man, J. Invest. Dermatol. 28: 291–304.

    PubMed  CAS  Google Scholar 

  • Epstein, W. L., Baer, H., Dawson, C. R., and Khuraw, R. G., 1974, Poison oak hyposensitization, Arch. Dermatol. 109: 356–360.

    Article  PubMed  CAS  Google Scholar 

  • Fisher, A. A., 1952, Some immunologic phenomena in treatment of and patch testing for ragweed oil dermatitis, J. Invest. Dermatol. 19: 217–279.

    Article  Google Scholar 

  • Forsbeck, M., Skog, E., and Ytterborn, K. H., 1971, Allergic diseases among relatives of patients with allergic contact dermatitis, Acta Derm. Venereol. 51: 123–128.

    PubMed  CAS  Google Scholar 

  • Frey, J. R., and Wenk, P., 1958, Experimental studies on the pathogenesis of contact eczema in the guinea pig, Int. Arch. Allergy Appl. Immunol. 11: 81–100.

    Article  Google Scholar 

  • Geczy, A. F., and Baumgarten, A., 1970, Lymphocyte transformation in contact sensitivity, Immunology 19: 189.

    PubMed  CAS  Google Scholar 

  • Goeckerman, W. H., 1931, Treatment of psoriasis. Continued observations on the use of crude coal tar and ultraviolet light, Arch. Dermatol. 24: 446–450.

    Article  Google Scholar 

  • Harber, L. C., Harris, H., and Baer, R. L., 1966a, Structural features of photoallergy to salicylanilides and related compounds, J. Invest. Dermatol. 46: 303–308.

    PubMed  CAS  Google Scholar 

  • Harber, L. C., Harris, H., and Baer, R. L., 1966, Photoallergic contact dermatitis to halogenated salicylanilides and related compounds, Arch. Dermatol. 94: 255–262.

    Article  PubMed  CAS  Google Scholar 

  • Haxthausen, H., 1943, Allergic dermatitis: Studies in identical twins, Acta Derm. Venereol. 23: 438–457.

    Google Scholar 

  • Haxthausen, H., 1947, Studies on the role of lymphocytes as “transmitters” of hypersensitiveness in allergic eczema, Acta Derm. Venereol. 27: 275–286.

    CAS  Google Scholar 

  • Herman, P. S., and Sams, W. M., 1971, Requirement for carrier protein in salicylanilide sensitivity. The migration-inhibition test in contact photoallergy, J. Lab. Clin. Med. 77: 572–579.

    PubMed  CAS  Google Scholar 

  • Hinrichs, D. J., and Gibbins, H. L., 1975, The in vitro detection of antigen sensitivity in contact dermatitis by lymphocyte transformation, Cell. Immunol. 18: 343–350.

    Article  PubMed  CAS  Google Scholar 

  • Hjorth, N., and Roed-Petersen, J., 1976, Occupational protein contact dermatitis in food handlers, Contact Dermatitis 2: 28–42.

    Article  PubMed  CAS  Google Scholar 

  • Jillson, O. F., and Baughman, R. D., 1963, Contact photo-dermatitis from bithionol, Arch. Dermatol. 88: 409–418.

    Article  PubMed  CAS  Google Scholar 

  • Jung, E. G., Dummler, U., and Immrich, H., 1968, Photoallergie durch 4-chlor-2-hydroxy-Benzoesäure-n-Butylamid. I. Lichtbiologische Untersuchungen zur Antigenbildung, Arch. Klin. Exp. Dermatol. 232: 403–412.

    PubMed  CAS  Google Scholar 

  • Klareskog, L., Tjernlund, U., Forsum, U., and Peterson, P. A., 1977, Epidermal Langerhans cells express Ia antigens, Nature (London) 268: 248–250.

    Article  CAS  Google Scholar 

  • Kligman, A. M., 1958, Poison ivy (Rhus) dermatitis, Arch. Dermatol. 77: 149–180.

    Article  CAS  Google Scholar 

  • Kochevar, I. E., Zalar, G. L., Einbinder, J., Harber, L. C., 1979, Assay of contact photosensitivity to Musk Ambrette in guinea pigs, J. Invest. Dermatol. 73: 144–146.

    Article  Google Scholar 

  • Lawrence, H. S., 1956, The cellular transfer of cutaneous hypersensitivity of tuberculin type with components of disrupted leukocytes, Bull. N. Y. Acad. Med. 32: 236–238.

    PubMed  CAS  Google Scholar 

  • Leshaw, S., Simon, R. S., and Baer, R. L., 1977, Failure to induce tolerance to mechlorethamine hydrochloride, Arch. Dermatol. 113: 1406–1408.

    Article  PubMed  CAS  Google Scholar 

  • Levine, B., Ojeda, A., and Benacerraf, B., 1963, Studies on artificial antigens. III. The genetic control of the immune response to hapten poly-l-lysine conjugates in guinea pigs, J. Exp. Med. 118: 953–957.

    Article  PubMed  CAS  Google Scholar 

  • Lowney, E., 1968, Immunologic unresponsiveness to a contact sensitizer in man, J. Invest. Dermatol. 51: 411–417.

    PubMed  CAS  Google Scholar 

  • Macher, E., and Chase, M. W., 1969, Studies on the sen-sitization of animals with simple chemical compounds. XII. The influence of excision of allergenic depots on onset of delayed hypersensitivity and tolerance, J. Exp. Med. 129: 103–121.

    Article  PubMed  CAS  Google Scholar 

  • Miller, A. E., Jr., and Levis, W. R., 1973, Studies on the contact sensitization of man with simple chemicals. I. Specific lymphocyte transformation in response to dinitrochlorobenzene sensitization, J. Invest. Dermatol. 61: 261–269.

    Article  PubMed  CAS  Google Scholar 

  • Morikawa, F., Hakayama, Y., Fukuda, M., Hamann, M., Yokoyama, Y., Nagura, T., Ishihara, M., Toda, K., 1974, Techniques for evaluation of phototoxicity and photoallergy in laboratory animals and man, in: Sunlight and Man ( T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, J. Seiji, and A. Kukita, eds), pp. 529–558, University of Tokyo Press, Tokyo.

    Google Scholar 

  • Nordqvist, B., and Rosenthal, S. A., 1978, Studies on DNCB contact sensitivity in guinea pigs by the macrophage migration test, Int. Arch. Allergy Appl. Immunol. 56: 73–78.

    Article  PubMed  CAS  Google Scholar 

  • Parrish, J. A., Fitzpatrick, T. B., Tanenbaum, L., and Pathak, M. A., 1974, Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light, N. Engl. J. Med. 291: 1207–1211.

    Article  PubMed  CAS  Google Scholar 

  • Pathak, M. A., and Kramer, D. M., 1969, Photosensitization of skin in vivo by furocoumarins (psoralens), Biochim. Biophys. Acta 195: 197–206.

    Article  PubMed  CAS  Google Scholar 

  • Polak, L., and Geleick, H., 1975, Differing mechanisms of tolerance and desensitization to DNCB in guinea pigs, Eur. J. Immunol. 5: 94–99.

    Article  PubMed  CAS  Google Scholar 

  • Raab, O., Über die Wirkung fluoreszierender Stoffe auf Infusorien, Z. Biol. 39: 524.

    Google Scholar 

  • Sidi, E., Hincky, M., and Gervais, A., 1955, Allergic sensitization and photosensitization to Phenergan cream, J. Invest. Dermatol. 24: 345–352.

    Article  PubMed  CAS  Google Scholar 

  • Silberberg, I., Baer, R. L., Rosenthal, S. A., Thorbecke, G. J., and Berezowsky, V., 1975, Dermal and intravascular Langerhans cells at sites of passively induced allergic contact sensitivity, Cell. Immunol. 18: 435–453.

    Article  PubMed  CAS  Google Scholar 

  • Silberberg, I., Thorbecke, G. J., Baer, R. L., and Berezowsky, V., 1976, Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes, Cell. Immunol. 25: 137–151.

    Article  Google Scholar 

  • Smith, S. Z., and Epstein, J. H., 1977, Photocontact dermatitis to halogenated salicylanilides and related compounds, Arch. Dermatol. 113: 1372–1374.

    Article  PubMed  CAS  Google Scholar 

  • Storck, H., and Schwarz-Speck, M., 1974, Different response to experimental sensitization by epicutaneous and intracutaneous application of bacterial antigens, Monogr. Allergy 8: 79–82.

    PubMed  CAS  Google Scholar 

  • Thomas, D. W., Forni, G., Shevach, E. M., and Green, I., 1977, The role of the macrophage as the stimulatory cell in contact sensitivity, J. Immunol. 118: 1677–1681.

    PubMed  CAS  Google Scholar 

  • Turk, J. L., and Parker, D., 1976, Modulation of T-lymphocyte function by B-lymphocytes in delayed hypersensitivity, Int. Arch. Allergy Appl. Immunol. 49: 241–246.

    Article  Google Scholar 

  • Vinson, L. K., and Flatt, R. S., 1962, Photosensitization by tetrachlorosalicylanilide, J. Invest. Dermatol. 38: 327–328.

    PubMed  CAS  Google Scholar 

  • Walker, F. B., Smith, J. D., and Maibach, H. I., 1967, Genetic factors in human allergic contact dermatitis, Int. Arch. Allergy Appl. Immunol. 32: 453.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson, D. S., 1961, Photodermatitis due to tetrachlorosalicylanilide, Br. J. Dermatol. 73: 213–219.

    Article  PubMed  CAS  Google Scholar 

  • Willis, I., and Kligman, A. M., 1968, Mechanism of the persistent light reactor, J. Invest. Dermatol. 51: 385–393.

    PubMed  CAS  Google Scholar 

  • Wolf-Jürgensen, P., 1966, Basophil Leucocytes in Delayed Hypersensitivity: Experimental Studies in Man Using the Skin Window Technique, Munksgaard, Copenhagen.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, New York University School of Medicine, New York, New York, 10016, USA

    Rudolf L. Baer

  2. Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    David R. Bickers

Authors
  1. Rudolf L. Baer
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  2. David R. Bickers
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Editor information

Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

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© 1981 Plenum Publishing Corporation

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Baer, R.L., Bickers, D.R. (1981). Allergic Contact Dermatitis, Photoallergic Contact Dermatitis, and Phototoxic Dermatitis. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_16

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  • DOI: https://doi.org/10.1007/978-1-4615-7228-2_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7230-5

  • Online ISBN: 978-1-4615-7228-2

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