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Role of Proteinases in Cutaneous Inflammation

  • Chapter
Immunodermatology

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 7))

Abstract

Proteinases, which are enzymes capable of degrading proteins, are necessary for normal metabolic function of the epidermis (Lazarus et al., 1975). Epidermal cells are phagocytic, and proteinases are necessary for digestion of endocytosed exogenous proteins (Nordquist et al., 1966; Wolff and Schreiner, 1969; Wolff and Honigsmann, 1968, Wolff and Konrad, 1972). Proteinases also play a role in the programmed catabolism associated with keratinization (Lazarus and Hatcher, 1975), in the autolysis of sebaceous cells associated with sebum secretion (Brandes et al., 1965), and in the phagocytosis and degradation of melanin granules (Olson et al., 1970; Wolff and Honigsmann, 1972; Otaki and Seiji, 1971). This chapter will emphasize the importance of proteinases as inflammatory agents, and it will explore the role of proteinases in psoriasis and pemphigus vulgaris.

This is Publication No. 35 of the Dermatological Research Laboratories of the Duke University Medical Center. This work was supported by grants from the National Institute of Arthritis, Metabolic, and Digestive Diseases (7 RO1 AM17370-04), (5T32 AM07093-02).

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Authors and Affiliations

  1. Department of Medicine, Division of Dermatology, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Gerald S. Lazarus, Roderick M. Farb & Charlotte A. Thomas

Authors
  1. Gerald S. Lazarus
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  2. Roderick M. Farb
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  3. Charlotte A. Thomas
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Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Bijan Safai M.D.  & Robert A. Good Ph.D., M.D.  & 

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Lazarus, G.S., Farb, R.M., Thomas, C.A. (1981). Role of Proteinases in Cutaneous Inflammation. In: Safai, B., Good, R.A. (eds) Immunodermatology. Comprehensive Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7228-2_11

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  • DOI: https://doi.org/10.1007/978-1-4615-7228-2_11

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