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The Search for Progesterone-Dependent Proteins Secreted by Human Endometrium

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Hormones and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 138))

Abstract

It has been generally agreed that the mechanism of steroid hormone action in human endometrium is similar to the model developed from studies in a variety of experimental animals (1–6). Briefly outlined, the model has three main features: 1) steroids bind to hormone and tissue-specific intracellular receptors with high affinity resulting in an “activated” steroid-receptor complex; 2) this complex translocates to the nucleus and binds to specific “acceptor” and “effector” sites on the genome; 3) binding induces the synthesis of messenger ribonucleic acids that are processed, transported to the cytoplasm and translated into proteins that alter cell function. A complete definition of a steroid hormone receptor, therefore, should not only include data on binding kinetics for the receptor-steroid interaction but also a direct correlation with the control of some known biological activity in the target tissue.

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Authors and Affiliations

  1. Vincent Memorial and Mass. General Hospitals, Boston, MA, USA

    David T. MacLaughlin, Paul E. Sylvan & George S. Richardson

  2. Dept. Obstet. & Gynec., Harvard Medical School, Boston, MA, USA

    David T. MacLaughlin, Paul E. Sylvan & George S. Richardson

Authors
  1. David T. MacLaughlin
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  2. Paul E. Sylvan
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  3. George S. Richardson
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Editors and Affiliations

  1. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, USA

    Wendell W. Leavitt

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© 1982 Plenum Press, New York

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MacLaughlin, D.T., Sylvan, P.E., Richardson, G.S. (1982). The Search for Progesterone-Dependent Proteins Secreted by Human Endometrium. In: Leavitt, W.W. (eds) Hormones and Cancer. Advances in Experimental Medicine and Biology, vol 138. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7192-6_7

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  • DOI: https://doi.org/10.1007/978-1-4615-7192-6_7

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