Abstract
Organophosphorus compounds (OPC) are known to cause a specific secondary type of demyelination in nervous tissues: lesions in the axis cylinder and myelin sheath, both in the central nervous system and the peripheral nervous system, have been described, as a result of their neurotoxic action.(1–5) To our knowledge, no review or recent monograph has appeared, dealing with the effects brought about by demyelinating OPC on protein and lipid metabolism of CNS and PNS. Some contributions in this field have, however, appeared in these last years, partially covering this subject matter.(4,6–10) Therefore, I have concentrated mostly on this problem and have tried to collect the most relevant and recent literature in the specific field. As is known, the economic importance of the OPC as insecticides is remarkable.(11,12) A detailed and adequate study of their toxicity and metabolism also is of interest, but this aspect will not be particularly reviewed in this paper.
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Porcellati, G. (1971). Demyelinating Cholinesterase Inhibitors: Lipid and Protein Metabolism. In: Lajtha, A. (eds) Alterations of Chemical Equilibrium in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7175-9_19
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DOI: https://doi.org/10.1007/978-1-4615-7175-9_19
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