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Amino Acid Transport

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Book cover Handbook of Neurochemistry

Abstract

The transport of amino acids to and from the central nervous system is of considerable interest. To a greater extent than most other tissues, central nervous system tissues in vitro take up amino acids to well above their concentrations in the incubation medium. Presumably the transport systems responsible for this uptake and for exchange and efflux in vitro are also those responsible for transport between brain cells, and interstitial and cerebrospinal fluids in living animals. In spite of the highly artificial nature of in vitro systems, phenomena such as dependence of uptake on energy or specific ions are best studied in brain slices and similar preparations. Changes in amino acid concentrations in living brain are severely restricted by that loosely defined complex of processes and structures known collectively as the “blood-brain barrier”; consequently in vivo studies of amino acid transport are largely studies of the properties of this “barrier.”

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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, N.Y., USA

    Stephen R. Cohen & Abel Lajtha

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  1. Stephen R. Cohen
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  2. Abel Lajtha
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  1. Neurochemistry and Drug Addiction, New York State Research Institute, Ward’s Island, New York, New York, USA

    Abel Lajtha

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© 1972 Plenum Press, New York

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Cohen, S.R., Lajtha, A. (1972). Amino Acid Transport. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7172-8_21

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  • DOI: https://doi.org/10.1007/978-1-4615-7172-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7174-2

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