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Peptide Hydrolases

  • Chapter
Metabolic Reactions in the Nervous System

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Abstract

Exopeptidases constitute a group of hydrolytic enzymes capable of cleaving the NH2- or COOH- terminal amino acids of peptides or polypeptides. Despite the presence in brain of peptides with important physiological properties, the role of these hydrolases in peptide and protein turnover is still obscure. It is well known that brain proteins are in dynamic equilibrium with their environment, with the processes of synthesis matching those of degradation. Protein breakdown as a consequence is an orderly process in which different batteries of endo- and exopeptidases are linked together to form a degradative pathway leading to the liberation of smaller peptides or amino acids. So far only simple schemes can be postulated for the pathways of intracellular hydrolysis of proteins and peptides.

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Marks, N. (1970). Peptide Hydrolases. In: Lajtha, A. (eds) Metabolic Reactions in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7160-5_5

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