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Phosphatases

  • Chapter
Metabolic Reactions in the Nervous System

Abstract

Phosphatases are a diverse and ubiquitous group of enzymes which occur in most organisms and tissues. To date all nervous systems have been found to have at least nonspecific alkaline and acid phosphatases. No observed activity probably means no activity under experimental conditions, not the absence of phosphatases. The nonspecific alkaline and acid phosphatases have been extensively studied. Besides these, many specific phosphatases have been found in nervous tissue, but studies of these enzymes have been limited. The occurrence and gross histological localization of nonspecific alkaline and acid phosphatase in nervous tissue of mammals and birds are well known. Although no one species has been studied in detail through its complete life cycle, the general pattern of changes in activity and distribution of these nonspecific phosphatases during development is also fairly clear. Much less is known about specific or nonspecific phosphatases in other vertebrates, and practically nothing is known about phosphatases in invertebrate nervous systems. Most of the investigations have relied largely on histochemical methods, where applicable. As a result, the properties of phosphatases in nervous tissue are poorly known and must be extrapolated from the properties of similar enzymes isolated from other sources.

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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Stephen R. Cohen

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    Abel Lajtha

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Cohen, S.R. (1970). Phosphatases. In: Lajtha, A. (eds) Metabolic Reactions in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7160-5_4

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