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Metabolism of Phosphoinositides

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Metabolic Reactions in the Nervous System

Abstract

Present interest in the inositol lipids of brain began with the isolation of the diphosphoinositide fraction by Folch(1) and the observation by Dawson(2) that 32P was rapidly incorporated into these lipids in vitro. More recent work has shown that there are three brain phosphoinositides, phospha-tidylinositol or monophosphoinositide (I), diphosphoinositide (II), and triphosphoinositide (III). The chemistry and metabolism of these compounds was reviewed in some detail by Hawthorne and Kemp(3) in 1964, so this chapter concentrates on work that has appeared since then, giving brief summaries of earlier studies only where necessary to complete the account.

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Authors and Affiliations

  1. Department of Biochemistry, University of Birmingham, England

    J. N. Hawthorne & M. Kai

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  1. J. N. Hawthorne
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  2. M. Kai
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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Abel Lajtha

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© 1970 Plenum Press, New York

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Hawthorne, J.N., Kai, M. (1970). Metabolism of Phosphoinositides. In: Lajtha, A. (eds) Metabolic Reactions in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7160-5_17

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  • DOI: https://doi.org/10.1007/978-1-4615-7160-5_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7162-9

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