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Sterols

  • Chapter
Chemical Architecture of the Nervous System

Abstract

The high concentration of cholesterol in the nervous tissues and its localization in cell membranes, notably myelin, indicate an important role for this sterol and related compounds in growth, maturation, and metabolism of the brain. However, very little is known, not only about sterol function, but, until recently, about sterol composition and pathways of biosynthesis and metabolism in the brain, especially when compared with the liver. This lack of information is due to the great difficulty in isolating and identifying other sterols in the presence of large amounts of cholesterol and by the fact that age, anatomical areas, routes of administration greatly modify the results obtained in studying brain cholesterol biosynthesis and turnover.

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  1. Institutes of Pharmacology, Universities of Milan and Cagliari, Italy

    R. Paoletti, E. Grossi-Paoletti & R. Fumagalli

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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Abel Lajtha

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Paoletti, R., Grossi-Paoletti, E., Fumagalli, R. (1969). Sterols. In: Lajtha, A. (eds) Chemical Architecture of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7154-4_10

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