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Transfer RNAs

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Handbook of Genetics

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Abstract

This is an attempt to summarize what is known about the nucleotide sequences of transfer ribonucleic acids (tRNAs). Cloverleaf arrangements of the 34 tRNAs whose nucleotide sequences have been determined are shown in Figure 1. Also shown is the tyrosine tRNA precursor. Recent reviews on tRNA include those by Philipps (1969), Zachau (1969), Cramer (1971), Jacobson (1971), Chambers (1971), Gauss et al. (1971), Mehler and Chakraburthy (1971), Staehelin (1971), and Venkstern (1973).

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Literature Cited

  • Abelson, J., L. Barnett, S. Brenner, M. Gefter, A. Landy, R. Russell, and J. D. Smith, 1969 Mutant tyrosine transfer ribonucleic acids. FEBS Lett. 3:1–4.

    Article  PubMed  CAS  Google Scholar 

  • Abelson, J. N., M. L. Gefter, L. Barnett, A. Landy, R. L. Russell, and J. D. Smith, 1970 Mutant tyrosine transfer ribonucleic acids. J. Mol. Biol. 47:15–28.

    Article  PubMed  CAS  Google Scholar 

  • Altman, S. and J. D. Smith, 1971 Tyrosine tRNA precursor molecule: Polynucleotide sequence. Nature (London) New Biol. 233:35–39.

    CAS  Google Scholar 

  • Barrell, B. G. and B. F. C. Clark, 1974 Handbook of Nucleic Acid Sequences, Johnson-Bruvvers, Oxford.

    Google Scholar 

  • Barrell, B. G. and F. Sanger, 1969 The sequence of phenylalanine tRNA from E. coli. FEBS Lett. 3:275–278.

    Article  PubMed  CAS  Google Scholar 

  • Bayev, A. A., T. V. Venkstern, A. D. Mirzabekov, A. I. Krutilina, L. Li, and V. D. Axelrod, 1967 The primary structure of valine tRNA 1 of baker’s yeast. Mol. Biol. SSSR 1:754–766.

    Google Scholar 

  • Beltchev, B. and M. Grunberg-Manago, 1970a Preparation of a pG-fragment from tRNA(Stack)Phe yeast by chemical scission at the dihydrouracil, and inhibition of tRNA(Stack)Phe yeast charging by this fragment when combined with the -CCA half of this tRNA. FEBS Lett. 12:24–26.

    Article  PubMed  Google Scholar 

  • Beltchev, B. and M. Grunberg-Manago, 1970b Competitive inhibition of the acceptor activity of tRNA Tyr IIE. Coli by a combination of oligo G and a CCA terminated nineteen residue oligonucleotide of tRNA Tyr IIE. Coli . FEBS Lett. 12:27–29.

    Article  PubMed  Google Scholar 

  • Blank, H. U. and D. Söll, 1971 The nucleotide sequence of two leucine tRNA species from Escherichia coli K12. Biochem. Biophys. Res. Commun. 43:1192–1197.

    Article  PubMed  CAS  Google Scholar 

  • Bonnet, J., J. P. Ebel, and G. Dirheimer, 1971 Primary structure of tRNAVal 2 from brewer’s yeast. FEBS Lett. 15:286–290.

    Article  PubMed  CAS  Google Scholar 

  • Chambers, R. W., 1971 On the recognition of tRNA by its aminoacyl-tRNA ligase. Prog. Nucleic Acid Res. Mol. Biol. 11:489–525.

    Article  PubMed  CAS  Google Scholar 

  • Chang, S. H., N. R. Miller, and C. W. Harmon, 1971 Nucleotide sequence of “renaturable” leucine transfer ribonucleic acid. FEBS Lett. 17:265–268.

    Article  PubMed  CAS  Google Scholar 

  • Cory, S. and K. A. Marcker, 1970 The nucleotide sequence of methionine tRNAM. Eur. J. Biochem. 12:177–194.

    Article  PubMed  CAS  Google Scholar 

  • Cory, S., K. A. Marcker, S. K. Dube, and B. F. C. Clark, 1969 Primary structure of a methionine transfer RNA from Escherichia coli. Nature (London) 220:1039–1040.

    Article  Google Scholar 

  • Cramer, F., 1971 Three-dimensional structure of tRNA. Prog. Nucleic Acid Res. Mol. Biol. 11:391–421.

    Article  PubMed  CAS  Google Scholar 

  • Crick, F. H. C., 1966 Codon-anticodon pairing: The wobble hypothesis. J. Mol. Biol. 19:548–555.

    Article  PubMed  CAS  Google Scholar 

  • Doctor, B. P., J. E. Loebel, M. A. Sodd, and D. B. Winter, 1969 Nucleotide sequence of Escherichia coli tyrosine transfer ribonucleic acid. Science 163:693–695.

    Article  PubMed  CAS  Google Scholar 

  • Dube, S. K., K. A. Marcker, B. F. C. Clark, and S. Cory, 1968 Nucleotide sequence of N-formyl-methionyl-transfer RNA. Nature (London) 218:232–233.

    Article  CAS  Google Scholar 

  • Dube, S. K., K. A. Marcker, and A. Yudelevich, 1970 The nucleotide sequence of a leucine transfer RNA from E. coli. FEBS Lett. 9:168–170.

    Article  PubMed  CAS  Google Scholar 

  • Dudock, B. S. and G. Katz, 1969 Large oligonucleotide sequences in wheat germ phenylalanine transfer ribonucleic acid. J. Biol. Chem. 244:3069–3074.

    PubMed  CAS  Google Scholar 

  • Dudock, B. S., G. Katz, E. K. Taylor, and R. W. Holley, 1969 Primary structure of wheat germ phenylalanine transfer RNA. Proc. Natl. Acad. Sci. USA 62:941–945.

    Article  PubMed  CAS  Google Scholar 

  • Dudock, B. S., C. DiPeri, and M. S. Michael, 1970 On the nature of the yeast phenylalanine transfer ribonucleic acid synthetase recognition site. J. Biol. Chem. 245:2465–2468.

    PubMed  CAS  Google Scholar 

  • Dudock, B. S., C. DiPeri, K. Scileppi, and R. Reszelbach, 1971 The yeast phenylalanyltransfer RNA synthetase recognition site: The region adjacent to the dihydrouridine loop. Proc. Natl. Acad. Sci. USA 68:681–684.

    Article  PubMed  CAS  Google Scholar 

  • Folk, W. R. and M. Yaniv, 1972 Coding properties and nucleotide sequences of E. coli glutamine tRNAs. Nature (London) New Biol. 273:165–166.

    Google Scholar 

  • Gangloff, J., G. Keith, J. P. Ebel, and G. Dirheimer, 1971 Structure of aspartate-tRNA from brewer’s yeast. Nature (London) New Biol. 230:125–126.

    Article  CAS  Google Scholar 

  • Gauss, D. H., F. von der Haar, A. Maelicke, and F. Cramer, 1971 Recent results of tRNA research. Annu. Rev. Biochem. 40:1045–1078.

    Article  PubMed  CAS  Google Scholar 

  • Ginsberg, T., H. Rogg, and M. Staehelin, 1971 Nucleotide sequences of rat liver serine-tRNA. 3. The partial enzymatic digestion of serine-tRNA1 and derivation of its total primary structure. Eur. J. Biochem. 21:249–257.

    Article  PubMed  CAS  Google Scholar 

  • Goodman, H. M., J. Abelson, A. Landy, S. Brenner, and J. D. Smith, 1968 Amber suppression: A nucleotide change in the anticodon of a tyrosine transfer RNA. Nature (London) 217:1019–1024.

    Article  CAS  Google Scholar 

  • Goodman, H. M., J. N. Abelson, A. Landy, S. Zadrazil, and J. D. Smith, 1970 The nucleoside sequences of tyrosine transfer RNAs of Escherichia coli: Sequences of the amber suppressor su+ III transfer RNA, the wild type su III transfer RNA and tyrosine transfer RNAs species I and II. Eur. J. Biochem. 13:461–483.

    Article  PubMed  CAS  Google Scholar 

  • Harada, F. and S. Nishimura, 1972 Possible anticodon sequences of tRNAHis, tRNAAsn, and tRNAAsp from Escherichia coli B: Universal presence of nucleoside Q in the first position of the anticodons of these transfer ribonucleic acids. Biochemistry 11:301–308.

    Article  PubMed  CAS  Google Scholar 

  • Harada, F., F. Kimura, and S. Nishimura, 1969 Nucleotide sequence of valine tRNA 1 from E. coli B. Biochim. Biophys. Acta 195:590–592.

    PubMed  CAS  Google Scholar 

  • Harada, F., S. Sato, and S. Nishimura, 1972 Unusual CCA-stem structure of E. coli B tRNAp. FEBSLett. 19:352.

    Article  CAS  Google Scholar 

  • Hashimoto, S., M. Miyazaki, and S. Takemura, 1969 Nucleotide sequence of tyrosine transfer RNA from Torulopsis utilis. J. Biochem. 65:659–661.

    PubMed  CAS  Google Scholar 

  • Hirsh, D., 1970 Tryptophan tRNA of Escherichia coli. Nature (London) 228:57.

    Article  CAS  Google Scholar 

  • Hirsh, D., 1971 Tryptophan transfer RNA as the UGA suppressor. J. Mol. Biol. 58:439–458.

    Article  PubMed  CAS  Google Scholar 

  • Holley, R. W., J. Apgar, G. A. Everett, J. T. Madison, M. Marquisee, S. H. Merrill, J. R. Penswick, and A. Zamir, 1965 Structure of a ribonucleic acid. Science 147:1462.

    Article  PubMed  CAS  Google Scholar 

  • Holmquist, R., T. H. Jukes, and S. Pangburn, 1973 Evolution of transfer RNA. J. Mol. Biol. 78:91–116.

    Article  PubMed  CAS  Google Scholar 

  • Imura, N., G. B. Weiss, and R. W. Chambers, 1969 Reconstitution of alanine acceptor activity from fragments of yeast tRNA AlaII . Nature (London) 222:1147–1148.

    Article  CAS  Google Scholar 

  • Ishikura, H., Y. Yamada, and S. Nishimura, 1971 The nucleotide sequence of a serine tRNA from Escherichia coli. FEBS Lett. 16:68–70.

    Article  PubMed  CAS  Google Scholar 

  • Jacobson, K. B., 1971 Reaction of aminoacyl-tRNA synthetases with heterologous tRNA’s. Prog. Nucleic Acid Res. Mol. Biol. 11:461–488.

    Article  PubMed  CAS  Google Scholar 

  • Keith, G., A. Roy, J. P. Ebel, and G. Dirheimer, 1971 The nucleotide sequences of two tryptophane-tRNAs from brewer’s yeast. FEBS Lett. 17:306–308.

    Article  PubMed  CAS  Google Scholar 

  • Kim, S. H., G.J. Quigley, F. L. Suddath, A. McPherson, D. Sneeden, J. J. Kim, J. Weinzierl, and A. Rich, 1973 Three-dimensional structure of yeast phenylalanine transfer RNA: Folding of the polynucleotide chain. Science 179:285–288.

    Article  PubMed  CAS  Google Scholar 

  • Kim, S. H., F. L. Suddath, G.J. Quigley, A. McPherson, J. L. Sussman, A. H.J. Wang, N. C. Seeman, and A. Rich, 1974a Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science 185:435–440.

    Google Scholar 

  • Kim, S. H., J. L. Sussman, F. L. Suddath, G.J. Quigley, A. McPherson, A. H.J. Wang, N. C. Seeman, and A. Rich, 1974b The general structure of transfer RNA molecules. Proc. Natl. Acad. Sci. USA 71:4970–4974.

    Google Scholar 

  • Kimura, F., F. Harada, and S. Nishimura, 1971 Primary sequence of tRNAVal 1 from Escherichia coli B. II. Isolation of large fragments by limited digestion with RNases, and overlapping of fragments to deduce the total primary sequence. Biochemistry 10:3277–3283.

    Article  PubMed  CAS  Google Scholar 

  • Kowalski, S., T. Yamane, and J. R. Fresco, 1971 Nucleotide sequence of the “denaturable” leucine transfer RNA from yeast. Science 172:385–387.

    Article  PubMed  CAS  Google Scholar 

  • Kuntzel, H., J. Weissenbach, and G. Dirheimer, 1972 The sequences of nucleotides in tRNA ArgIII frorn brewer’s yeast. FEBS Lett. 25:189–191.

    Article  PubMed  CAS  Google Scholar 

  • Madison, J. T., and H. K. Kung, 1967 Large oligonucleotides isolated from yeast tyrosine transfer ribonucleic acid after partial digestion with ribonuclease T 1. J. Biol. Chem. 242:1324–1330.

    PubMed  CAS  Google Scholar 

  • Madison, J. T., G. A. Everett, and H. Kung, 1966 Nucleotide sequence of a yeast tyrosine transfer RNA. Science 153:531–534.

    Article  PubMed  CAS  Google Scholar 

  • Madison, J. T., S. J. Boguslawski, and G. H. Teetor, 1972 Nucleotide sequence of a lysine transfer ribonucleic acid from baker’s yeast. Science 176:687–689.

    Article  PubMed  CAS  Google Scholar 

  • Mehler, A. H. and K. Chakraburthy, 1971 Some questions about the structure and activity of aminoacyl-tRNA synthetases. Adv. Enzymoi 35:443–501.

    CAS  Google Scholar 

  • Merril, C. R., 1968 Reinvestigation of the primary structure of yeast alanine tRNA. Biopolymers 6:1727–1735.

    Article  PubMed  CAS  Google Scholar 

  • Mirzabekov, A. D., D. Lastity, E. S. Levina, and A. A. Bayev, 1971 Localization of two recognition sites in yeast valine tRNA I. Nature (London) New Biol. 229:21–22.

    CAS  Google Scholar 

  • Mizutani, T., M. Miyazaki, and S. Takemura, 1968 The primary structure of valine-I transfer ribonucleic acid from Torulopsis utilis. II. Partial digestion with ribonuclease T1 and derivation of the complete sequence. J. Biochem. 64:839–848.

    PubMed  CAS  Google Scholar 

  • Nakanishi, K., N. Furutachi, M. Funamizu, D. Grunberger, and I. B. Weinstein, 1970 Structure of the fluorescent Y base from yeast phenylalanine transfer ribonucleic acid. J. Am. Chem. Soc. 92:7617–7619.

    Article  PubMed  CAS  Google Scholar 

  • Ohashi, Z., F. Harada, and S. Nishimura, 1972 Primary sequence of glutamic acid tRNA II from Escherichia coli. FEBS Lett. 20:239–241.

    Article  PubMed  CAS  Google Scholar 

  • Philipps, G. R., 1969 Primary structure of transfer RNA. Nature (London) 223:374–377.

    Article  CAS  Google Scholar 

  • Pinkerton, T. C., G. Paddock, and J. Abelson, 1972 Bacteriophage T4 tRNALeu. Nature (London) New Biol. 240:88–90.

    Article  CAS  Google Scholar 

  • Rajbhandary, U. L. and S. H. Chang, 1968 Studies on polynucleotides. LXXXII. Yeast phenylalanine transfer ribonucleic acid: Partial digestion with ribonuclease T1 and derivation of the total primary structure. J. Biol. Chem. 242:598–608.

    Google Scholar 

  • Rajbhandary, U. L., S. H. Chang, A. Stuart, R. D. Faulkner, R. M. Hoskinson, and H. G. Khorana, 1967 Studies on polynucleotides. LXVIIL The primary structure of yeast phenylalanine transfer RNA. Proc. Natl. Acad. Sci. USA 57:751–758.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, R. J., 1972 Structures of two glycyl-tRNAs from Staphylococcus epidermidis. Nature (London) New Biol. 237:44–45.

    Article  CAS  Google Scholar 

  • Robertus, J. D., J. E. Ladner, J. T. Finch, D. Rhodes, R. S. Brown, B. F. C. Clark, and A. Klug, 1974 Structure of yeast phenylalanine tRNA at 3 Å resolution. Nature (London) 250:546–551.

    Article  CAS  Google Scholar 

  • Roe, B., M. Sirover, R. Williams, and B. Dudock, 1971 New heterologous mischarging reactions with yeast phenylalanyl transfer RNA synthetase. Arch. Biochem. Biophys. 147:176–177.

    Article  PubMed  CAS  Google Scholar 

  • Roe, B., M. Sirover, and B. Dudock, 1972 On the nature of the yeast phenylalanine t-RNA synthetase recognition site—The role of three nucleotides in the acceptor stem region. Fed. Proc. 31:450.

    Google Scholar 

  • Schulman, L. H., 1972 Loss of methionine acceptor activity by modification of a specific guanosine residue in the acceptor stem of E. coli tRNAMed. Fed. Proc. 31:449.

    Google Scholar 

  • Schulman, L. H. and R. W. Chambers, 1968 Transfer RNA. II. A structural basis for alanine acceptor activity. Proc. Natl. Acad. Sci. USA 61:308–315.

    Article  PubMed  CAS  Google Scholar 

  • Singer, C. E. and G. R. Smith, 1972 Histidine regulation in Salmonella typhimurium. XIII. Nucleotide sequence of histidine transfer ribonucleic acid. J. Biol. Chem. 247:2989–3000.

    PubMed  CAS  Google Scholar 

  • Singer, C. E., G. R. Smith, R. Cortese, and B. N. Ames, 1972 Mutant tRNAHis ineffective in repression and lacking two pseudouridine modifications. Nature (London) New Biol. 238:72–74.

    CAS  Google Scholar 

  • Smith, C. J., A. N. Ley, P. D’Obrenan, and S. K. Mitra, 1971 The structure and coding specificity of a lysine transfer ribonucleic acid from the haploid yeast Saccharomyces cerevisiae S288C. J. Biol. Chem. 246:7817–7819.

    PubMed  CAS  Google Scholar 

  • Smith, J. D., L. Barnett, S. Brenner, and R. L. Russell, 1970 More mutant tyrosine transfer ribonucleic acids. J. Mol. Biol. 54:1–14.

    Article  PubMed  CAS  Google Scholar 

  • Squires, C. and J. Carbon, 1971 Normal and mutant glycine transfer RNAs. Nature (London) New Biol. 233:274–277.

    CAS  Google Scholar 

  • Staehelin, M., 1971 The primary structure of transfer ribonucleic acid. Experientia 27:1–11.

    Article  PubMed  CAS  Google Scholar 

  • Staehelin, M., H. Rogg, B. C. Baguley, T. Ginsberg, and W. Wehrli, 1968 Structure of a mammalian serine tRNA. Nature (London) 219:1363–1365.

    Article  CAS  Google Scholar 

  • Takemura, S., T. Mizutani, and M. Miyazaki, 1968 The primary structure of valine-I transfer ribonucleic acid from Torulopsis utilis. J. Biochem. 63:277–278.

    PubMed  CAS  Google Scholar 

  • Takemura, S., M. Murakami, and M. Miyazaki, 1969a Nucleotide sequence of isoleucine transfer RNA from Torulopsis utilis. J. Biochem. 65:489.

    PubMed  CAS  Google Scholar 

  • Takemura, S., M. Murakami, and M. Miyazaki, 1969b The primary structure of isoleucine tRNA from Torulopsis utilis: Complete digestion with ribonucleases and construction of model of its secondary structure. J. Biochem. 65:553–565.

    PubMed  CAS  Google Scholar 

  • Uziel, M. and H. G. Gassen, 1969a Phenylalanine transfer ribonucleic acid from E. coli B: Isolation and characterization of oligonucleotides from ribonuclease T1 and ribonu-clease A hydrolysates. Biochemistry 8:1643–1656.

    Article  PubMed  CAS  Google Scholar 

  • Uziel, M. and H. G. Gassen, 1969b Structure of tRNAPhe. Fed. Proc. 28:409.

    Google Scholar 

  • Venkstern, T., 1973 The Primary Structure of tRNA, Plenum Press, New York.

    Google Scholar 

  • Woodward, W. R. and E. Herbert, 1971 Coding properties of reticulocyte and yeast isoacceptor lysine transfer ribonucleic acids in hemoglobin synthesis. Fed. Proc. 30:1217.

    Google Scholar 

  • Yaniv, M. and B. G. Barrell, 1969 Nucleotide sequence of E. coli B tRNA ValI . Nature (London) 222:278–279.

    Article  CAS  Google Scholar 

  • Yaniv, M. and B. G. Barrell, 1971 Sequence relationship of three valine acceptor tRNAs from Escherichia coli. Nature (London) New Biol. 233:113–114.

    CAS  Google Scholar 

  • Yarus, M. and B. G. Barrell, 1971 The sequence of nucleotides in tRNAIle from E. coli B. Biochem. Biophys. Res. Commun. 43:729–734.

    Article  PubMed  CAS  Google Scholar 

  • Zachau, H. G., 1969 Transfer ribonucleic acids. Angew. Chem. Int. Ed. 8:711–726.

    Article  CAS  Google Scholar 

  • Zachau, H. G., D. Diitting, and H. Feldman, 1966a Nucleotidsequenzen zweier serinspezifischer Transfer-ribonucleinsauren. Angew. Chem. 78:392–393.

    Article  Google Scholar 

  • Zachau, H. G., D. Diitting, and H. Feldman, 1966b The structures of two serine transfer ribonucleic acids. Hoppe Seyter’s Z. Physiol. Chem. 347:212–235.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. U.S. Plant, Soil, and Nutrition Laboratory, U.S. Department of Agriculture, Ithaca, New York, USA

    James T. Madison

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  1. James T. Madison
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Editors and Affiliations

  1. Department of Biological Sciences, Northwestern University, Evanston, Illinois, USA

    Robert C. King (Professor of Genetics) (Professor of Genetics)

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© 1976 Plenum Press, New York

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Madison, J.T. (1976). Transfer RNAs. In: King, R.C. (eds) Handbook of Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7148-3_10

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