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Mutations

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Genetics and Molecular Biology of Anaerobic Bacteria

Part of the book series: Brock/Springer Series in Contemporary Bioscience ((BROCK/SPRINGER))

Abstract

Mutagenesis is a basic approach to bacterial genetics. Microbiologists previously have shown only limited interest in mutant strains of anaerobes, and this interest was directed toward such modified properties as increased formation of metabolites, e.g., neutral solvents of Clostridium acetobutylicum or hyperproduc-tion of clostridial toxins for vaccines. Investigators often faced unwanted losses in properties of laboratory strains in which the mechanism may have been related to “strain degeneration,” spontaneous mutation, or plasmid loss. Only the pioneering work was focused on obtaining mutants to inquire into such basic mechanisms as oxygen sensitivity, and those unrealistic approaches to “aerobize” anaerobes of course failed.

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  1. Madeleine Sebald
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  1. Unité des Anaérobies, Institut Pasteur, 75724, Paris, France

    Madaleine Sebald

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Sebald, M. (1993). Mutations. In: Sebald, M. (eds) Genetics and Molecular Biology of Anaerobic Bacteria. Brock/Springer Series in Contemporary Bioscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7087-5_5

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