Abstract
In the 1970s, Ionesco and Bouanchaud (1973) reported the first demonstration for a dostridial species that bacteriocin production was associated with the presence of a small plasmid. It was later shown that Clostridium perfringens CPN50 synthesized large quantities of the bacteriocin BCN5 after irradiation with ultraviolet light and that this bactericidal protein was secreted into the medium (Ionesco et al., 1974). Subsequent genetic studies revealed that the bacteriocinogenic plasmid, pIP404, was about 10 kb in size and could be mobilized by conjugation by certain cryptic plasmids commonly found in C. perfringens (Brefort et al., 1977). Several years later, pIP404 was adopted by our laboratory as a model system for studying DNA damage-inducible genes in the Clostridia and as a source of material for vector construction.
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Cole, S.T., Garnier, T. (1993). Molecular Genetic Studies of UV-Inducible Bacteriocin Production in Clostridium perfringens . In: Sebald, M. (eds) Genetics and Molecular Biology of Anaerobic Bacteria. Brock/Springer Series in Contemporary Bioscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7087-5_17
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DOI: https://doi.org/10.1007/978-1-4615-7087-5_17
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