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Computer Assisted Methods for Nucleic Acid Sequencing

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Book cover Genetic Engineering

Part of the book series: Genetic Engineering ((GEPM))

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Abstract

Eight years ago procedures such as pyrimidine tracts (1) and wandering spots (2) were the methods of choice for determining the sequence of short stretches of nucleic acids. The use of computers at that time to assist in the collection and analysis of these sequences would have seemed unnecessary. However, the development of more productive and technically simpler methods for DNA sequencing has caused a dramatic increase in the total volume of nucleic acid sequence data. For example, within a single journal (Nucleic Acids Research) published bi-weekly, newly determined sequence data, including more than 27,000 nucleotides, were published during the first five months of 1980. The accumulation of nucleotide sequence data in the near future will undoubtedly continue at an increased rate. Such large quantities of sequence data have provided the stimulus to establish centralized sequence storage banks.* The utilization of computers at these centers to store and catalog sequence data is one obvious but trivial way in which computer technology has been useful to those interested in nucleotide sequences.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    T. R. Gingeras & R. J. Roberts

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  1. T. R. Gingeras
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  2. R. J. Roberts
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Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

  2. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

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© 1981 Springer Science+Business Media New York

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Gingeras, T.R., Roberts, R.J. (1981). Computer Assisted Methods for Nucleic Acid Sequencing. In: Setlow, J.K., Hollaender, A. (eds) Genetic Engineering. Genetic Engineering. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7075-2_12

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  • DOI: https://doi.org/10.1007/978-1-4615-7075-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7077-6

  • Online ISBN: 978-1-4615-7075-2

  • eBook Packages: Springer Book Archive

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