Skip to main content
SpringerLink
Log in

Oxidation of Cholesterol by Rat Liver Mitochondria: Influence of Ethyl α-p-Chlorophenoxyisobutyrate

  • Chapter
Drugs Affecting Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 4))

  • 58 Accesses

Abstract

Ethyl α-p-chlorophenoxyisobutyrate (CPIB) has been shown to inhibit cholesterol synthesis from acetate (1) or mevalonate (2) and to interfere with lipoprotein synthesis and/or release by the liver (3). In an effort to clarify other parameters of its mode of action, we have investigated the effect of CPIB upon the oxidation of cholesterol-26-14C to 14CO2 by suitably fortified mitochondrial preparations from rat livers.

Supported in part by Grants HE-03299 and HD-02721 and a Research Career Award K6-HE-734 from the National Institutes of Health, U.S.A.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Avoy, D. R., E. A. Swyryd and R. G. Gould. J. Lipid Res. 6: 369 (1965).

    PubMed  CAS  Google Scholar 

  2. Azarnoff, D. L., D. R. Tucker and G. A. Barr. Metabolism 14: 959 (1965).

    Article  PubMed  CAS  Google Scholar 

  3. Gould, R. G., E. A. Swyryd, D. Avoy and B. Coan. In: Progr. Biochemical Pharmacology 2, ed.: D. Kritchevsky, R. Paoletti and D. Steinberg, S. Karger, Basel. 1967, p. 345.

    Google Scholar 

  4. Mann, G. V. Clin. Chem. 7:275 (1961).

    PubMed  CAS  Google Scholar 

  5. Van Handel, E. and D. B. Zilversmit. J. Lab. Clin. Med. 50: 152 (1957).

    Google Scholar 

  6. Fiske, C. H. and Y. Subbarow. J. Mol. Chem. 66:375 (1925).

    CAS  Google Scholar 

  7. Whitehouse, M. W., E. Staple and S. Gurin. J. Biol. Chem. 234 276 (1959).

    PubMed  CAS  Google Scholar 

  8. Kritchevsky, D., R. R. Kolman, M. W. Whitehouse, M. C. Cottrell and E. Staple. J. Lipid Res. 1:83 (1959).

    CAS  Google Scholar 

  9. Bessey, O. A., O. H. Lowry and M. J. Brock. J. Biol. Chem. 164:321 (1946).

    PubMed  CAS  Google Scholar 

  10. Fishman, W H, In: Methods of Enzymatic Analysis, ed.: H. Bergmeyer, Academic Press, New York, 1963, p. 869.

    Google Scholar 

  11. Best, H. M. and C. H. Duncan. J. Lab. Clin. Med. 64:634 (1964).

    PubMed  CAS  Google Scholar 

  12. Kritchevsky, D. In: Metabolism of Lipids as Related to Atherosclerosis, ed.: F. Kummerow, Charles C. Thomas, Springfield. 1965, p. 106.

    Google Scholar 

  13. Duncan, C. H., M. M. Best and A. Despopoulos. Circulation 30:III-7 (1964) (Abstract).

    Google Scholar 

  14. Paget, G. E. J. Atherosclerosis Res. 3:729 (1963).

    Article  CAS  Google Scholar 

  15. Hess, R., W. Riess and W. Staubli, In: Progr, Biochemical Pharmacology 2, ed.: D. Kritchevsky, R. Paoletti and D. Steinberg, S. Karger, Basel. 1967, p. 325.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, Pennsylvania, 19104, USA

    David Kritchevsky, Shirley A. Tepper, Pauline Sallata, Joan R. Kabakjian & Vincent J. Cristofalo

Authors
  1. David Kritchevsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shirley A. Tepper
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pauline Sallata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joan R. Kabakjian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vincent J. Cristofalo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Department of Geriatrics, Faculty of Medicine, University of Uppsala, Uppsala, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  3. King Gustaf Vth Research Institute, Stockholm, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  4. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Plenum Press

About this chapter

Cite this chapter

Kritchevsky, D., Tepper, S.A., Sallata, P., Kabakjian, J.R., Cristofalo, V.J. (1969). Oxidation of Cholesterol by Rat Liver Mitochondria: Influence of Ethyl α-p-Chlorophenoxyisobutyrate. In: Holmes, W.L., Carlson, L.A., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6866-7_45

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-6866-7_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6868-1

  • Online ISBN: 978-1-4615-6866-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation