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The Effects of Trans Isomerized Trilinolein on Plasma Lipids of Man

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Drugs Affecting Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 4))

Abstract

Double bonds in naturally occurring dietary fatty acids are in the cis configuration. The trans isomers of these acids, such as those appearing during hydrogenation of oils, differ markedly in their spatial configuration from the natural form (Pig- 1). Since we have been interested in the relationship between the configuration of dietary fatty acids and their effect on plasma lipids and lipoproteins in man (1, 2), we selected trans isomerized fat as a model to use in studies designed to determine whether the lipid-lowering effect of unsaturated fats is related to their configuration or whether unsaturation per se produces the observed effect.

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References

  1. Spritz, N. Circulation 36: 11–38 (1967) (Abstract).

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  2. Spritz, N. and Mishkel, M.A. Unpublished data.

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  3. Fredrickson, D. S. and Lees, R. S. Circulation 31: 321 (1965).

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  4. Lees, R. S. and Hatch, F. T. J. Lab. Clin. Med. 61: 518 (1963).

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  5. Hill, R., Webster, W. W., Linazasoro, J. M. and Chaikoff, I. L. J. Lipid Res. 1: 150 (1960).

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  6. Havel, R. J. unpublished data.

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Author information

Authors and Affiliations

  1. The Rockefeller University, New York, N.Y., USA

    Maurice A. Mishkel & Norton Spritz

Authors
  1. Maurice A. Mishkel
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  2. Norton Spritz
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Department of Geriatrics, Faculty of Medicine, University of Uppsala, Uppsala, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  3. King Gustaf Vth Research Institute, Stockholm, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  4. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

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© 1969 Pleum Press

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Mishkel, M.A., Spritz, N. (1969). The Effects of Trans Isomerized Trilinolein on Plasma Lipids of Man. In: Holmes, W.L., Carlson, L.A., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6866-7_29

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  • DOI: https://doi.org/10.1007/978-1-4615-6866-7_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6868-1

  • Online ISBN: 978-1-4615-6866-7

  • eBook Packages: Springer Book Archive

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