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The Effect of Nicotinic Acid Treatment on the Chemical Composition of Plasma Lipoprotein Classes in Man

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Drugs Affecting Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 4))

Abstract

Nicotinic acid is one of several available agents which lower the levels of plasma lipids (1). For several years, we have been using nicotinic acid in the treatment of patients with coronary heart disease and elevated plasma lipid levels. In our clinical experience we have been impressed by its effectiveness in lowering both plasma triglycerides and plasma cholesterol. This suggested to us that nicotinic acid reduced the levels of both the triglyceride- rich very-low-density (VLD) lipoproteins (LP) and the cholesterol-rich low-density (LD) LP. The purpose of this study was to establish

  1. 1)

    Does treatment with nicotinic acid lower the levels of both VLD- and LD-LP in various types of hyperlipoproteinemia?

  2. 2)

    Does treatment with nicotinic acid change the chemical composition of the three major plasma LP classes?

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References

  1. Altschul, R. Niacin in vascular disorders and hyperlipemia (Ed. by R. Altschul), Charles C. Thomas, Springfield, Ill. (1964)

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  2. Carlson, L. A. and Orö, L. Läkartidn. 63: 4281 (1966)

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  3. Carlson, L. A. and Orö, L. to be published

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  4. Carlson, L. A. and Mossfeldt, F. Acta Physiol. Scand. 62: 51 (1964)

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Karolinska sjukhuset and King Gustaf V. Research Institute, Stockholm, Sweden

    Lars A. Carlson

Authors
  1. Lars A. Carlson
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Department of Geriatrics, Faculty of Medicine, University of Uppsala, Uppsala, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  3. King Gustaf Vth Research Institute, Stockholm, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  4. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

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© 1969 Pleum Press

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Carlson, L.A. (1969). The Effect of Nicotinic Acid Treatment on the Chemical Composition of Plasma Lipoprotein Classes in Man. In: Holmes, W.L., Carlson, L.A., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6866-7_26

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  • DOI: https://doi.org/10.1007/978-1-4615-6866-7_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6868-1

  • Online ISBN: 978-1-4615-6866-7

  • eBook Packages: Springer Book Archive

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