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Drugs Affecting Lipid Metabolism pp 261–278Cite as

Some Factors Affecting Release of Clearing Factor Lipase from Isolated Perfused Rat Heart

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 4))

Abstract

The presence of a lipolytic enzyme has been demonstrated in a variety of tissue preparations of the heart (2–10). This enzyme has been referred to rather indiscriminately as “lipoprotein lipase,” a term which was introduced by Korn (2). According to Korn this lipase was extracted from rat heart acetone powder in an ammonia buffer in the presence of heparin; the enzyme had little activity unless the substrate which was a coconut oil emulsion (Ediol) was “activated” by serum.

As stated by Robinson (1) the term “clearing factor lipase” is preferred in this communication.

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References

  1. Robinson, D.S. Advances in Lipid Res. Ed. by R. Paoletti and D. Kritchevaky 1:133 (1963)

    Google Scholar 

  2. Korn, E. C. J. Biol. Chem. 215:1 (1955)

    CAS  Google Scholar 

  3. Zemplanyi, T. and Grafnetter, D. Arch. Int. Pharmacodyn. Therap. 122 :57 (1959)

    Google Scholar 

  4. Hollenberg, C. H. J. Clin. Invest. 39:1282 (1960)

    Article  CAS  Google Scholar 

  5. Bjorntorp, P. and Furman, R. H. Am. J. Physiol. 203:323 (1962)

    PubMed  CAS  Google Scholar 

  6. George, J. C. and Iype, P. T. Am. J. Physiol. 204:165 (1963)

    PubMed  CAS  Google Scholar 

  7. Schnatz, J. D., Ormsby, J. W., and Williams, R. H. Am. J. Physiol. 205:401 (1963)

    PubMed  CAS  Google Scholar 

  8. Alousi, A.A. and Mallow, S. Am. J. Physiol. 206:603 (1964)

    PubMed  CAS  Google Scholar 

  9. Kessler, J.I. J. Clin. Invest. 42:362 (1963)

    Article  CAS  Google Scholar 

  10. Zemplenyi, T. Advances in Lipid Res. Ed. by R. Paoletti and D. Kritchevsky 2:235 (1964)

    Google Scholar 

  11. Meng, H. C. Third World Congress on Cardiology (1958)

    Google Scholar 

  12. Crass, M. F., III and Meng, H. C. Am. J. Physiol. 206:610 (1964)

    PubMed  CAS  Google Scholar 

  13. Robinson, D.S. and Jennings, M. A. J. Lipid Res. 6:222 (1965)

    PubMed  CAS  Google Scholar 

  14. Nakatani, M., Nakamura, M., and Torii, S. Proc. Exper. Biol. Med. 107:853 (1961)

    CAS  Google Scholar 

  15. Dole, V. P. J. Clin. Invest. 35: 150 (1956)

    Article  CAS  Google Scholar 

  16. Edgren, B. Arch. Int. Pharmacodyn. Therap. 27: 225 (1960)

    Google Scholar 

  17. Lever, W. F. and Baskys, B. J. Invest. Dermatol. 28:317 (1957)

    CAS  Google Scholar 

  18. Engelberg, H. J. Appi. Physiol. 12:292 (1958)

    CAS  Google Scholar 

  19. Meng, H. C. and Edgren, B. Am. J. Physiol. 204:691 (1963)

    CAS  Google Scholar 

  20. Havel, R.J. and Fredrickson, D.S. J. Clin. Invest. 35:1025 (1956)

    Article  CAS  Google Scholar 

  21. Enser, M. B., Kunz, F., Borensztajn, J., Opie, L. H., and Robinson, D.S. Biochem. J. 104:306 (1967)

    PubMed  CAS  Google Scholar 

  22. Kreisberg, R. A. Am. J. Physiol. 210:379 (1966)

    PubMed  CAS  Google Scholar 

  23. Rändle, P.J., Garland, P.B., Hales, C.N., and Newsholme, E. A. The Lancet 1:785 (1963)

    Article  Google Scholar 

  24. Robinson, J. and Newsholme, E. A. Biochem J. 104:2c (1967)

    Google Scholar 

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Author information

Author notes

  1. E. Aktin

    Present address: Dept. of Neurology, Faculty of Medicine, University of Istanbul, Istanbul, Turkey

  2. M. F. Crass III

    Present address: Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA

Authors and Affiliations

  1. Department of Physiology, School of Medicine, Vanderbilt University, Nashville, Tennessee, 37203, USA

    H. C. Meng, E. Aktin, M. F. Crass III & M. Ghosal

Authors
  1. H. C. Meng
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  2. E. Aktin
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  3. M. F. Crass III
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  4. M. Ghosal
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Department of Geriatrics, Faculty of Medicine, University of Uppsala, Uppsala, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  3. King Gustaf Vth Research Institute, Stockholm, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  4. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

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© 1969 Plenum Press

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Meng, H.C., Aktin, E., Crass, M.F., Ghosal, M. (1969). Some Factors Affecting Release of Clearing Factor Lipase from Isolated Perfused Rat Heart. In: Holmes, W.L., Carlson, L.A., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6866-7_22

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  • DOI: https://doi.org/10.1007/978-1-4615-6866-7_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6868-1

  • Online ISBN: 978-1-4615-6866-7

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