Influence of Lipolytic and Antilipolytic Agents on Synthesis of Adipose Tissue Lipoprotein Lipase

Abstract

Adipose tissue forms an important site in the breakdown and assimilation of serum triglycerides and its quantitative role in this process may be even greater than thus far believed if it turns out that intact triglyceride molecules cannot be metabolized by the liver^1,2. The only known enzyme concerned with the hydrolysis of serum triglycerides is lipoprotein lipase (LPL) and its activity may be one of the factors regulating serum triglyceride level. Hence, knowledge of the mode of control of the synthesis and activity of LPL is important. The enzyme has an exceptionally rapid turnover, the half-life of rat adipose tissue LPL being only a few hours^3–5. This makes that even a short-term control of the LPL action may be exerted through alteration of the rate of enzyme synthesis. However, this applies so far only to rat since turnover measurements of the corresponding human enzyme have not been made.