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Regulatory Factors in Ketogenesis and in the Metabolism of Triglycerides by Liver

  • Chapter
Drugs Affecting Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 4))

Abstract

The physiological and biochemical mechanisms by which the intact animal regulates its metabolism of lipids and the role of the liver in the control of blood lipids has long been a topic of interest in this laboratory. Our approach to the problem has been the examination of the uptake, metabolism, and release of the serum lipids and lipoproteins by the isolated, perfused rat liver. Our attention has been focused for some time on the various factors regulating the output and accumulation of triglyceride by the liver. It is now evident that a variety of hormones influence the hepatic metabolism of triglycerides. On the following pages is a brief discussion of some of the recent work from this laboratory on lipid metabolism in insulin deficiency (induced by alloxan diabetes), (2) on the effects of glucagon and insulin on hepatic triglyceride metabolism, and (3) on the modulating effects of substrate concentration (free fatty acids) on these processes. In order to present a coherent picture of the current status of the work, it will be useful to recount some of the earlier findings.

This work was supported by Grant AM-01677 from the National Institutes of Health, U.S. Public Health Service, by Grant 67-694 from The American Heart Association, and by Public Health Service Research Grant No. UI-00412 from the National Center for Urban and Industrial Health.

Postdoctoral Fellow of the National Institutes of Health, U.S. Public Health Service, Grant No. 5-F2-AM-29,395.

Research Associate, Supported by the PHS Health Sciences Advancement Award, Grant No. 5-S04-FR-06067-02 from Vanderbilt University.

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Author information

Author notes

  1. Donald R. Van Harken

    Present address: Bristol Laboratories, Syracuse, New York, USA

Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee, 37203, USA

    Murray Heimberg, Donald R. Van Harken, Ira Weinstein & Miloslav Kohout

Authors
  1. Murray Heimberg
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  2. Donald R. Van Harken
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  3. Ira Weinstein
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  4. Miloslav Kohout
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Department of Geriatrics, Faculty of Medicine, University of Uppsala, Uppsala, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  3. King Gustaf Vth Research Institute, Stockholm, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  4. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

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© 1969 Plenum Press

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Heimberg, M., Van Harken, D.R., Weinstein, I., Kohout, M. (1969). Regulatory Factors in Ketogenesis and in the Metabolism of Triglycerides by Liver. In: Holmes, W.L., Carlson, L.A., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6866-7_16

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  • DOI: https://doi.org/10.1007/978-1-4615-6866-7_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6868-1

  • Online ISBN: 978-1-4615-6866-7

  • eBook Packages: Springer Book Archive

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